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Gene: FAM134C |
Gene summary for FAM134C |
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Gene information | Species | Human | Gene symbol | FAM134C | Gene ID | 162427 |
Gene name | reticulophagy regulator family member 3 | |
Gene Alias | FAM134C | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q86VR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162427 | FAM134C | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.28e-38 | 6.40e-01 | 0.294 |
162427 | FAM134C | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.23e-14 | 1.00e+00 | 0.3487 |
162427 | FAM134C | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.71e-10 | 2.99e-01 | 0.281 |
162427 | FAM134C | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.91e-47 | 8.71e-01 | 0.3859 |
162427 | FAM134C | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.38e-15 | 6.07e-01 | 0.2585 |
162427 | FAM134C | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.28e-34 | 6.12e-01 | 0.3005 |
162427 | FAM134C | P1T-E | Human | Esophagus | ESCC | 8.51e-07 | 2.75e-01 | 0.0875 |
162427 | FAM134C | P2T-E | Human | Esophagus | ESCC | 3.80e-18 | 2.25e-01 | 0.1177 |
162427 | FAM134C | P4T-E | Human | Esophagus | ESCC | 1.06e-20 | 2.38e-01 | 0.1323 |
162427 | FAM134C | P5T-E | Human | Esophagus | ESCC | 8.15e-12 | 1.16e-01 | 0.1327 |
162427 | FAM134C | P8T-E | Human | Esophagus | ESCC | 4.08e-23 | 3.38e-01 | 0.0889 |
162427 | FAM134C | P9T-E | Human | Esophagus | ESCC | 9.02e-06 | 7.24e-02 | 0.1131 |
162427 | FAM134C | P10T-E | Human | Esophagus | ESCC | 6.86e-14 | 1.06e-01 | 0.116 |
162427 | FAM134C | P11T-E | Human | Esophagus | ESCC | 1.30e-09 | 4.25e-01 | 0.1426 |
162427 | FAM134C | P12T-E | Human | Esophagus | ESCC | 5.44e-19 | 3.46e-01 | 0.1122 |
162427 | FAM134C | P15T-E | Human | Esophagus | ESCC | 2.95e-16 | 3.39e-01 | 0.1149 |
162427 | FAM134C | P16T-E | Human | Esophagus | ESCC | 1.03e-13 | 2.23e-01 | 0.1153 |
162427 | FAM134C | P17T-E | Human | Esophagus | ESCC | 2.34e-05 | 2.39e-01 | 0.1278 |
162427 | FAM134C | P19T-E | Human | Esophagus | ESCC | 2.75e-03 | 3.44e-01 | 0.1662 |
162427 | FAM134C | P20T-E | Human | Esophagus | ESCC | 9.56e-12 | 1.72e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM134C | SNV | Missense_Mutation | novel | c.11N>T | p.Ala4Val | p.A4V | Q86VR2 | protein_coding | tolerated_low_confidence(0.47) | benign(0) | TCGA-AC-A3HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM134C | SNV | Missense_Mutation | c.581N>G | p.Tyr194Cys | p.Y194C | Q86VR2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FAM134C | insertion | Frame_Shift_Ins | novel | c.1107_1108insAGCAGCTGGAGTAGTTACATTGTCATCATCTTTTTTTTTGAGA | p.Pro370SerfsTer86 | p.P370Sfs*86 | Q86VR2 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
FAM134C | insertion | In_Frame_Ins | novel | c.1051_1052insGGCCTTGGGAGTTGGCAAGAGGGAGGGAAGGAAGGAGAGCAAAAT | p.Ile351delinsArgProTrpGluLeuAlaArgGlyArgGluGlyArgArgAlaLysPhe | p.I351delinsRPWELARGREGRRAKF | Q86VR2 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
FAM134C | insertion | Frame_Shift_Ins | novel | c.1284_1285insCTATGCCCGGCTAATTTTTCTTTTGGTATTTTTAGTAGAAATG | p.Gly429LeufsTer27 | p.G429Lfs*27 | Q86VR2 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
FAM134C | SNV | Missense_Mutation | novel | c.958N>C | p.Ser320Arg | p.S320R | Q86VR2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM134C | SNV | Missense_Mutation | rs150018457 | c.817N>A | p.Asp273Asn | p.D273N | Q86VR2 | protein_coding | tolerated(0.11) | probably_damaging(0.985) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
FAM134C | SNV | Missense_Mutation | novel | c.720G>C | p.Glu240Asp | p.E240D | Q86VR2 | protein_coding | tolerated(0.64) | benign(0) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAM134C | insertion | Frame_Shift_Ins | novel | c.246_247insT | p.Ala83CysfsTer22 | p.A83Cfs*22 | Q86VR2 | protein_coding | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
FAM134C | SNV | Missense_Mutation | c.1013T>C | p.Met338Thr | p.M338T | Q86VR2 | protein_coding | tolerated(0.39) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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