|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: FAM127C |
Gene summary for FAM127C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM127C | Gene ID | 441518 |
| Gene name | retrotransposon Gag like 8B | |
| Gene Alias | CXX1c | |
| Cytomap | Xq26.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q17RB0 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 441518 | FAM127C | P1T-E | Human | Esophagus | ESCC | 1.72e-07 | 7.04e-01 | 0.0875 |
| 441518 | FAM127C | P2T-E | Human | Esophagus | ESCC | 1.57e-30 | 5.80e-01 | 0.1177 |
| 441518 | FAM127C | P4T-E | Human | Esophagus | ESCC | 1.24e-22 | 5.78e-01 | 0.1323 |
| 441518 | FAM127C | P8T-E | Human | Esophagus | ESCC | 7.45e-22 | 3.05e-01 | 0.0889 |
| 441518 | FAM127C | P9T-E | Human | Esophagus | ESCC | 2.93e-26 | 7.32e-01 | 0.1131 |
| 441518 | FAM127C | P10T-E | Human | Esophagus | ESCC | 1.37e-26 | 5.04e-01 | 0.116 |
| 441518 | FAM127C | P11T-E | Human | Esophagus | ESCC | 3.42e-13 | 5.34e-01 | 0.1426 |
| 441518 | FAM127C | P12T-E | Human | Esophagus | ESCC | 3.24e-50 | 9.27e-01 | 0.1122 |
| 441518 | FAM127C | P15T-E | Human | Esophagus | ESCC | 4.64e-19 | 3.73e-01 | 0.1149 |
| 441518 | FAM127C | P16T-E | Human | Esophagus | ESCC | 8.55e-15 | 1.13e-01 | 0.1153 |
| 441518 | FAM127C | P17T-E | Human | Esophagus | ESCC | 5.39e-03 | 2.45e-01 | 0.1278 |
| 441518 | FAM127C | P19T-E | Human | Esophagus | ESCC | 1.42e-06 | 8.56e-01 | 0.1662 |
| 441518 | FAM127C | P20T-E | Human | Esophagus | ESCC | 2.29e-12 | 3.16e-01 | 0.1124 |
| 441518 | FAM127C | P21T-E | Human | Esophagus | ESCC | 2.36e-30 | 6.46e-01 | 0.1617 |
| 441518 | FAM127C | P23T-E | Human | Esophagus | ESCC | 9.37e-23 | 8.17e-01 | 0.108 |
| 441518 | FAM127C | P24T-E | Human | Esophagus | ESCC | 6.54e-12 | 3.49e-01 | 0.1287 |
| 441518 | FAM127C | P26T-E | Human | Esophagus | ESCC | 6.70e-16 | 4.36e-01 | 0.1276 |
| 441518 | FAM127C | P27T-E | Human | Esophagus | ESCC | 4.48e-18 | 3.38e-01 | 0.1055 |
| 441518 | FAM127C | P28T-E | Human | Esophagus | ESCC | 1.11e-12 | 2.70e-01 | 0.1149 |
| 441518 | FAM127C | P30T-E | Human | Esophagus | ESCC | 1.05e-15 | 6.15e-01 | 0.137 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM127C | SNV | Missense_Mutation | c.47N>G | p.Leu16Arg | p.L16R | Q17RB0 | protein_coding | tolerated(0.33) | benign(0) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FAM127C | SNV | Missense_Mutation | c.95N>T | p.Thr32Met | p.T32M | Q17RB0 | protein_coding | tolerated(0.13) | benign(0.115) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FAM127C | SNV | Missense_Mutation | c.50N>A | p.Arg17Gln | p.R17Q | Q17RB0 | protein_coding | tolerated(0.07) | benign(0.05) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| FAM127C | SNV | Missense_Mutation | c.112N>A | p.Asp38Asn | p.D38N | Q17RB0 | protein_coding | tolerated(0.24) | possibly_damaging(0.619) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| FAM127C | SNV | Missense_Mutation | novel | c.182N>G | p.Asp61Gly | p.D61G | Q17RB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6164-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FAM127C | SNV | Missense_Mutation | c.157N>A | p.Val53Met | p.V53M | Q17RB0 | protein_coding | deleterious(0.05) | benign(0.071) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| FAM127C | SNV | Missense_Mutation | c.287N>A | p.Gly96Asp | p.G96D | Q17RB0 | protein_coding | tolerated(0.11) | benign(0.27) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| FAM127C | SNV | Missense_Mutation | novel | c.62N>A | p.Arg21His | p.R21H | Q17RB0 | protein_coding | deleterious(0.01) | possibly_damaging(0.796) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| FAM127C | SNV | Missense_Mutation | novel | c.88C>T | p.Pro30Ser | p.P30S | Q17RB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FAM127C | SNV | Missense_Mutation | novel | c.272N>G | p.Leu91Arg | p.L91R | Q17RB0 | protein_coding | tolerated(0.07) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |