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Gene: FAM122B |
Gene summary for FAM122B |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM122B | Gene ID | 159090 |
Gene name | PABIR family member 2 | |
Gene Alias | FAM122B | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q7Z309 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
159090 | FAM122B | LZE24T | Human | Esophagus | ESCC | 6.23e-22 | 5.06e-01 | 0.0596 |
159090 | FAM122B | P1T-E | Human | Esophagus | ESCC | 3.74e-08 | 3.76e-01 | 0.0875 |
159090 | FAM122B | P2T-E | Human | Esophagus | ESCC | 1.79e-10 | 2.15e-01 | 0.1177 |
159090 | FAM122B | P4T-E | Human | Esophagus | ESCC | 1.42e-13 | 2.74e-01 | 0.1323 |
159090 | FAM122B | P5T-E | Human | Esophagus | ESCC | 4.32e-06 | 1.01e-01 | 0.1327 |
159090 | FAM122B | P8T-E | Human | Esophagus | ESCC | 1.54e-11 | 2.00e-01 | 0.0889 |
159090 | FAM122B | P9T-E | Human | Esophagus | ESCC | 3.61e-11 | 2.19e-01 | 0.1131 |
159090 | FAM122B | P10T-E | Human | Esophagus | ESCC | 5.48e-22 | 3.99e-01 | 0.116 |
159090 | FAM122B | P11T-E | Human | Esophagus | ESCC | 9.96e-04 | 1.66e-01 | 0.1426 |
159090 | FAM122B | P12T-E | Human | Esophagus | ESCC | 9.59e-11 | 1.29e-01 | 0.1122 |
159090 | FAM122B | P15T-E | Human | Esophagus | ESCC | 6.65e-09 | 1.37e-01 | 0.1149 |
159090 | FAM122B | P16T-E | Human | Esophagus | ESCC | 2.47e-04 | 4.43e-02 | 0.1153 |
159090 | FAM122B | P19T-E | Human | Esophagus | ESCC | 3.27e-11 | 6.02e-01 | 0.1662 |
159090 | FAM122B | P20T-E | Human | Esophagus | ESCC | 9.28e-15 | 3.45e-01 | 0.1124 |
159090 | FAM122B | P21T-E | Human | Esophagus | ESCC | 1.77e-16 | 3.33e-01 | 0.1617 |
159090 | FAM122B | P22T-E | Human | Esophagus | ESCC | 6.71e-17 | 3.15e-01 | 0.1236 |
159090 | FAM122B | P23T-E | Human | Esophagus | ESCC | 6.96e-17 | 4.49e-01 | 0.108 |
159090 | FAM122B | P24T-E | Human | Esophagus | ESCC | 1.42e-05 | 1.80e-01 | 0.1287 |
159090 | FAM122B | P26T-E | Human | Esophagus | ESCC | 4.11e-13 | 2.54e-01 | 0.1276 |
159090 | FAM122B | P27T-E | Human | Esophagus | ESCC | 2.75e-02 | 5.36e-02 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM122B | SNV | Missense_Mutation | c.794N>A | p.Pro265His | p.P265H | Q7Z309 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.459) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
FAM122B | SNV | Missense_Mutation | c.241N>A | p.Gly81Ser | p.G81S | Q7Z309 | protein_coding | tolerated(0.16) | probably_damaging(1) | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM122B | SNV | Missense_Mutation | novel | c.590G>A | p.Arg197Lys | p.R197K | Q7Z309 | protein_coding | tolerated(0.18) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM122B | SNV | Missense_Mutation | c.697N>A | p.Ser233Thr | p.S233T | Q7Z309 | protein_coding | tolerated(0.08) | benign(0.359) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM122B | SNV | Missense_Mutation | c.574N>A | p.Glu192Lys | p.E192K | Q7Z309 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM122B | insertion | Frame_Shift_Ins | novel | c.75_76insAATCAACAATCAATGACTTCATGTAGACCTGTTG | p.Ala26AsnfsTer20 | p.A26Nfs*20 | Q7Z309 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
FAM122B | SNV | Missense_Mutation | c.223C>G | p.Gln75Glu | p.Q75E | Q7Z309 | protein_coding | deleterious(0.02) | benign(0.164) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM122B | SNV | Missense_Mutation | c.401C>T | p.Ser134Phe | p.S134F | Q7Z309 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
FAM122B | SNV | Missense_Mutation | c.248N>G | p.Asp83Gly | p.D83G | Q7Z309 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-CM-5863-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
FAM122B | SNV | Missense_Mutation | rs374009398 | c.632C>T | p.Ala211Val | p.A211V | Q7Z309 | protein_coding | tolerated(0.08) | benign(0.331) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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