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Gene: FAM114A1 |
Gene summary for FAM114A1 |
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Gene information | Species | Human | Gene symbol | FAM114A1 | Gene ID | 92689 |
Gene name | family with sequence similarity 114 member A1 | |
Gene Alias | Noxp20 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IWE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92689 | FAM114A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.75e-13 | 5.66e-01 | -0.1954 |
92689 | FAM114A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.20e-03 | -2.79e-01 | 0.0674 |
92689 | FAM114A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.34e-07 | -3.38e-01 | 0.3005 |
92689 | FAM114A1 | A002-C-010 | Human | Colorectum | FAP | 1.25e-06 | -2.30e-01 | 0.242 |
92689 | FAM114A1 | A015-C-203 | Human | Colorectum | FAP | 1.10e-15 | -2.37e-01 | -0.1294 |
92689 | FAM114A1 | A002-C-201 | Human | Colorectum | FAP | 2.32e-03 | -2.26e-01 | 0.0324 |
92689 | FAM114A1 | A002-C-203 | Human | Colorectum | FAP | 4.05e-03 | -1.83e-01 | 0.2786 |
92689 | FAM114A1 | A001-C-108 | Human | Colorectum | FAP | 3.28e-08 | -2.20e-01 | -0.0272 |
92689 | FAM114A1 | A002-C-205 | Human | Colorectum | FAP | 5.80e-09 | -3.23e-01 | -0.1236 |
92689 | FAM114A1 | A001-C-104 | Human | Colorectum | FAP | 1.23e-02 | -1.59e-01 | 0.0184 |
92689 | FAM114A1 | A015-C-006 | Human | Colorectum | FAP | 2.13e-03 | -5.30e-02 | -0.0994 |
92689 | FAM114A1 | A015-C-106 | Human | Colorectum | FAP | 2.45e-08 | -2.28e-01 | -0.0511 |
92689 | FAM114A1 | A002-C-114 | Human | Colorectum | FAP | 1.39e-06 | -2.21e-01 | -0.1561 |
92689 | FAM114A1 | A015-C-104 | Human | Colorectum | FAP | 2.38e-15 | -2.42e-01 | -0.1899 |
92689 | FAM114A1 | A001-C-014 | Human | Colorectum | FAP | 1.92e-06 | -9.92e-02 | 0.0135 |
92689 | FAM114A1 | A002-C-016 | Human | Colorectum | FAP | 1.61e-14 | -2.52e-01 | 0.0521 |
92689 | FAM114A1 | A015-C-002 | Human | Colorectum | FAP | 4.28e-03 | -2.24e-01 | -0.0763 |
92689 | FAM114A1 | A001-C-203 | Human | Colorectum | FAP | 5.71e-07 | -1.22e-01 | -0.0481 |
92689 | FAM114A1 | A002-C-116 | Human | Colorectum | FAP | 1.09e-16 | -3.05e-01 | -0.0452 |
92689 | FAM114A1 | A014-C-008 | Human | Colorectum | FAP | 8.58e-04 | -2.14e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM114A1 | SNV | Missense_Mutation | c.19G>A | p.Asp7Asn | p.D7N | Q8IWE2 | protein_coding | tolerated_low_confidence(0.09) | benign(0.019) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
FAM114A1 | SNV | Missense_Mutation | c.713N>A | p.Thr238Asn | p.T238N | Q8IWE2 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FAM114A1 | SNV | Missense_Mutation | c.547N>A | p.Glu183Lys | p.E183K | Q8IWE2 | protein_coding | tolerated(0.31) | benign(0.009) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
FAM114A1 | insertion | Frame_Shift_Ins | novel | c.512_513insCAGCCACTTTGGACCATCCGTAGGCT | p.Glu171AspfsTer10 | p.E171Dfs*10 | Q8IWE2 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
FAM114A1 | deletion | Frame_Shift_Del | novel | c.782delN | p.Leu262CysfsTer5 | p.L262Cfs*5 | Q8IWE2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FAM114A1 | SNV | Missense_Mutation | novel | c.1240G>A | p.Glu414Lys | p.E414K | Q8IWE2 | protein_coding | tolerated(0.82) | benign(0.001) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
FAM114A1 | SNV | Missense_Mutation | c.1688C>T | p.Pro563Leu | p.P563L | Q8IWE2 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
FAM114A1 | SNV | Missense_Mutation | c.334N>A | p.Glu112Lys | p.E112K | Q8IWE2 | protein_coding | deleterious(0.05) | benign(0.197) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM114A1 | SNV | Missense_Mutation | rs143144596 | c.937N>A | p.Glu313Lys | p.E313K | Q8IWE2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM114A1 | SNV | Missense_Mutation | rs149201693 | c.319N>A | p.Glu107Lys | p.E107K | Q8IWE2 | protein_coding | tolerated(0.05) | benign(0.263) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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