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Gene: FAM111B |
Gene summary for FAM111B |
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Gene information | Species | Human | Gene symbol | FAM111B | Gene ID | 374393 |
Gene name | FAM111 trypsin like peptidase B | |
Gene Alias | CANP | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0006260 | UniProtAcc | Q6SJ93 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374393 | FAM111B | C04 | Human | Oral cavity | OSCC | 1.12e-03 | 2.20e-01 | 0.2633 |
374393 | FAM111B | C21 | Human | Oral cavity | OSCC | 7.38e-22 | 9.15e-01 | 0.2678 |
374393 | FAM111B | C30 | Human | Oral cavity | OSCC | 8.26e-09 | 3.54e-01 | 0.3055 |
374393 | FAM111B | C38 | Human | Oral cavity | OSCC | 3.61e-03 | 2.56e-01 | 0.172 |
374393 | FAM111B | C43 | Human | Oral cavity | OSCC | 2.94e-14 | 3.24e-01 | 0.1704 |
374393 | FAM111B | C46 | Human | Oral cavity | OSCC | 2.63e-15 | 3.65e-01 | 0.1673 |
374393 | FAM111B | C57 | Human | Oral cavity | OSCC | 3.22e-06 | 3.12e-01 | 0.1679 |
374393 | FAM111B | LN22 | Human | Oral cavity | OSCC | 2.85e-06 | 5.29e-01 | 0.1733 |
374393 | FAM111B | LN46 | Human | Oral cavity | OSCC | 2.68e-18 | 6.76e-01 | 0.1666 |
374393 | FAM111B | SYSMH3 | Human | Oral cavity | OSCC | 1.58e-18 | 7.41e-01 | 0.2442 |
374393 | FAM111B | PTC05 | Human | Thyroid | PTC | 4.70e-03 | 2.80e-01 | 0.2065 |
374393 | FAM111B | ATC2 | Human | Thyroid | ATC | 7.49e-03 | 5.28e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM111B | SNV | Missense_Mutation | rs374250882 | c.313N>A | p.Glu105Lys | p.E105K | Q6SJ93 | protein_coding | deleterious(0.01) | benign(0.354) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM111B | SNV | Missense_Mutation | c.49N>C | p.Asp17His | p.D17H | Q6SJ93 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
FAM111B | insertion | Frame_Shift_Ins | novel | c.1515_1516insACTTTTTT | p.Pro506ThrfsTer6 | p.P506Tfs*6 | Q6SJ93 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM111B | SNV | Missense_Mutation | novel | c.1797G>T | p.Leu599Phe | p.L599F | Q6SJ93 | protein_coding | tolerated(0.36) | benign(0.011) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
FAM111B | SNV | Missense_Mutation | novel | c.338C>T | p.Ala113Val | p.A113V | Q6SJ93 | protein_coding | deleterious(0.02) | possibly_damaging(0.559) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAM111B | SNV | Missense_Mutation | c.962N>A | p.Arg321Lys | p.R321K | Q6SJ93 | protein_coding | tolerated(0.12) | benign(0.035) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM111B | SNV | Missense_Mutation | c.8N>T | p.Ser3Phe | p.S3F | Q6SJ93 | protein_coding | tolerated(0.21) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM111B | SNV | Missense_Mutation | c.328N>A | p.Ala110Thr | p.A110T | Q6SJ93 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM111B | SNV | Missense_Mutation | c.553N>A | p.Leu185Ile | p.L185I | Q6SJ93 | protein_coding | deleterious(0.05) | possibly_damaging(0.635) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM111B | SNV | Missense_Mutation | c.747T>G | p.Ile249Met | p.I249M | Q6SJ93 | protein_coding | deleterious(0.01) | possibly_damaging(0.652) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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