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Gene: FAM106A |
Gene summary for FAM106A |
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Gene information | Species | Human | Gene symbol | FAM106A | Gene ID | 80039 |
Gene name | family with sequence similarity 106 member A | |
Gene Alias | FAM106A | |
Cytomap | 17p11.2 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80039 | FAM106A | HCC1 | Human | Liver | HCC | 2.14e-18 | 2.18e+00 | 0.5336 |
80039 | FAM106A | HCC2 | Human | Liver | HCC | 2.24e-21 | 2.16e+00 | 0.5341 |
80039 | FAM106A | HCC5 | Human | Liver | HCC | 1.43e-16 | 1.45e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM106A | SNV | Missense_Mutation | novel | c.86N>G | p.Tyr29Cys | p.Y29C | Q4KMX7 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-B6-A0I1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM106A | SNV | Missense_Mutation | novel | c.166N>T | p.Arg56Cys | p.R56C | Q4KMX7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.835) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM106A | SNV | Missense_Mutation | c.140T>G | p.Ile47Ser | p.I47S | Q4KMX7 | protein_coding | deleterious_low_confidence(0) | benign(0.402) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
FAM106A | SNV | Missense_Mutation | novel | c.194N>A | p.Arg65Gln | p.R65Q | Q4KMX7 | protein_coding | tolerated_low_confidence(0.4) | benign(0.417) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM106A | SNV | Missense_Mutation | novel | c.211N>T | p.Ala71Ser | p.A71S | Q4KMX7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.567) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM106A | SNV | Missense_Mutation | novel | c.391N>A | p.Asp131Asn | p.D131N | Q4KMX7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.728) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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