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Gene: FAM103A1 |
Gene summary for FAM103A1 |
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Gene information | Species | Human | Gene symbol | FAM103A1 | Gene ID | 83640 |
Gene name | RNA guanine-7 methyltransferase activating subunit | |
Gene Alias | C15orf18 | |
Cytomap | 15q25.2 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q9BTL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83640 | FAM103A1 | P1T-E | Human | Esophagus | ESCC | 1.37e-11 | 8.29e-01 | 0.0875 |
83640 | FAM103A1 | P2T-E | Human | Esophagus | ESCC | 7.01e-38 | 6.42e-01 | 0.1177 |
83640 | FAM103A1 | P4T-E | Human | Esophagus | ESCC | 2.25e-47 | 1.16e+00 | 0.1323 |
83640 | FAM103A1 | P5T-E | Human | Esophagus | ESCC | 1.53e-25 | 5.12e-01 | 0.1327 |
83640 | FAM103A1 | P8T-E | Human | Esophagus | ESCC | 3.50e-43 | 9.28e-01 | 0.0889 |
83640 | FAM103A1 | P9T-E | Human | Esophagus | ESCC | 4.44e-31 | 6.75e-01 | 0.1131 |
83640 | FAM103A1 | P10T-E | Human | Esophagus | ESCC | 1.51e-46 | 6.82e-01 | 0.116 |
83640 | FAM103A1 | P11T-E | Human | Esophagus | ESCC | 3.43e-26 | 4.57e-01 | 0.1426 |
83640 | FAM103A1 | P12T-E | Human | Esophagus | ESCC | 2.11e-34 | 6.93e-01 | 0.1122 |
83640 | FAM103A1 | P15T-E | Human | Esophagus | ESCC | 1.21e-43 | 8.33e-01 | 0.1149 |
83640 | FAM103A1 | P16T-E | Human | Esophagus | ESCC | 3.24e-43 | 7.84e-01 | 0.1153 |
83640 | FAM103A1 | P17T-E | Human | Esophagus | ESCC | 5.26e-11 | 4.15e-01 | 0.1278 |
83640 | FAM103A1 | P19T-E | Human | Esophagus | ESCC | 4.66e-09 | 1.22e+00 | 0.1662 |
83640 | FAM103A1 | P20T-E | Human | Esophagus | ESCC | 1.79e-33 | 7.04e-01 | 0.1124 |
83640 | FAM103A1 | P21T-E | Human | Esophagus | ESCC | 1.33e-34 | 7.13e-01 | 0.1617 |
83640 | FAM103A1 | P22T-E | Human | Esophagus | ESCC | 6.00e-39 | 6.82e-01 | 0.1236 |
83640 | FAM103A1 | P23T-E | Human | Esophagus | ESCC | 5.85e-44 | 1.19e+00 | 0.108 |
83640 | FAM103A1 | P24T-E | Human | Esophagus | ESCC | 3.72e-20 | 4.26e-01 | 0.1287 |
83640 | FAM103A1 | P26T-E | Human | Esophagus | ESCC | 7.49e-63 | 1.11e+00 | 0.1276 |
83640 | FAM103A1 | P27T-E | Human | Esophagus | ESCC | 5.65e-15 | 4.23e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM103A1 | deletion | Frame_Shift_Del | novel | c.194delN | p.Arg65LysfsTer62 | p.R65Kfs*62 | Q9BTL3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FAM103A1 | SNV | Missense_Mutation | c.254G>A | p.Arg85Gln | p.R85Q | Q9BTL3 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM103A1 | SNV | Missense_Mutation | novel | c.170N>A | p.Arg57Gln | p.R57Q | Q9BTL3 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM103A1 | SNV | Missense_Mutation | novel | c.194N>T | p.Arg65Ile | p.R65I | Q9BTL3 | protein_coding | deleterious(0.01) | possibly_damaging(0.735) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM103A1 | SNV | Missense_Mutation | c.139G>T | p.Ala47Ser | p.A47S | Q9BTL3 | protein_coding | tolerated(0.66) | benign(0.019) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FAM103A1 | SNV | Missense_Mutation | c.155G>T | p.Arg52Ile | p.R52I | Q9BTL3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM103A1 | SNV | Missense_Mutation | novel | c.289G>A | p.Glu97Lys | p.E97K | Q9BTL3 | protein_coding | tolerated(0.26) | benign(0.234) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
FAM103A1 | SNV | Missense_Mutation | novel | c.169N>T | p.Arg57Trp | p.R57W | Q9BTL3 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM103A1 | SNV | Missense_Mutation | novel | c.346N>T | p.Gly116Cys | p.G116C | Q9BTL3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-EY-A548-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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