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Gene: FABP6 |
Gene summary for FABP6 |
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Gene information | Species | Human | Gene symbol | FABP6 | Gene ID | 2172 |
Gene name | fatty acid binding protein 6 | |
Gene Alias | I-15P | |
Cytomap | 5q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | P51161 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2172 | FABP6 | LZE24T | Human | Esophagus | ESCC | 1.48e-08 | 2.63e-01 | 0.0596 |
2172 | FABP6 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.79e-01 | 0.0875 |
2172 | FABP6 | P4T-E | Human | Esophagus | ESCC | 2.58e-28 | 5.77e-01 | 0.1323 |
2172 | FABP6 | P5T-E | Human | Esophagus | ESCC | 8.88e-05 | 1.04e-01 | 0.1327 |
2172 | FABP6 | P11T-E | Human | Esophagus | ESCC | 7.73e-16 | 7.03e-01 | 0.1426 |
2172 | FABP6 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 3.11e-01 | 0.1278 |
2172 | FABP6 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 5.42e-01 | 0.1662 |
2172 | FABP6 | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 3.71e-01 | 0.1124 |
2172 | FABP6 | P21T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.16e-01 | 0.1617 |
2172 | FABP6 | P23T-E | Human | Esophagus | ESCC | 2.50e-32 | 8.77e-01 | 0.108 |
2172 | FABP6 | P24T-E | Human | Esophagus | ESCC | 2.86e-08 | 2.17e-01 | 0.1287 |
2172 | FABP6 | P26T-E | Human | Esophagus | ESCC | 1.71e-05 | 1.98e-01 | 0.1276 |
2172 | FABP6 | P27T-E | Human | Esophagus | ESCC | 1.77e-22 | 4.11e-01 | 0.1055 |
2172 | FABP6 | P32T-E | Human | Esophagus | ESCC | 2.66e-09 | 2.51e-01 | 0.1666 |
2172 | FABP6 | P37T-E | Human | Esophagus | ESCC | 7.25e-13 | 2.49e-01 | 0.1371 |
2172 | FABP6 | P38T-E | Human | Esophagus | ESCC | 2.58e-10 | 3.56e-01 | 0.127 |
2172 | FABP6 | P40T-E | Human | Esophagus | ESCC | 1.70e-03 | 2.00e-01 | 0.109 |
2172 | FABP6 | P44T-E | Human | Esophagus | ESCC | 7.53e-03 | 1.53e-01 | 0.1096 |
2172 | FABP6 | P47T-E | Human | Esophagus | ESCC | 8.76e-07 | 1.39e-01 | 0.1067 |
2172 | FABP6 | P52T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.45e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FABP6 | SNV | Missense_Mutation | c.202N>C | p.Met68Leu | p.M68L | P51161 | protein_coding | tolerated(0.27) | benign(0.014) | TCGA-B6-A0RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FABP6 | SNV | Missense_Mutation | c.77N>A | p.Cys26Tyr | p.C26Y | P51161 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FABP6 | SNV | Missense_Mutation | c.22A>G | p.Met8Val | p.M8V | P51161 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FABP6 | SNV | Missense_Mutation | c.110G>T | p.Arg37Ile | p.R37I | P51161 | protein_coding | deleterious_low_confidence(0.03) | benign(0.082) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
FABP6 | SNV | Missense_Mutation | c.139N>T | p.Pro47Ser | p.P47S | P51161 | protein_coding | deleterious_low_confidence(0.03) | benign(0.006) | TCGA-EI-7004-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | SD | |
FABP6 | SNV | Missense_Mutation | c.235G>A | p.Glu79Lys | p.E79K | P51161 | protein_coding | tolerated(0.38) | possibly_damaging(0.829) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FABP6 | SNV | Missense_Mutation | novel | c.417N>T | p.Lys139Asn | p.K139N | P51161 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FABP6 | SNV | Missense_Mutation | c.349N>G | p.Lys117Glu | p.K117E | P51161 | protein_coding | tolerated(0.35) | benign(0.179) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FABP6 | SNV | Missense_Mutation | novel | c.135G>T | p.Lys45Asn | p.K45N | P51161 | protein_coding | deleterious_low_confidence(0.01) | benign(0.009) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FABP6 | SNV | Missense_Mutation | rs370149454 | c.460N>A | p.Val154Met | p.V154M | P51161 | protein_coding | tolerated(0.09) | possibly_damaging(0.75) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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