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Gene: EXOG |
Gene summary for EXOG |
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Gene information | Species | Human | Gene symbol | EXOG | Gene ID | 9941 |
Gene name | exo/endonuclease G | |
Gene Alias | ENDOGL1 | |
Cytomap | 3p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000737 | UniProtAcc | Q9Y2C4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9941 | EXOG | HCC1_Meng | Human | Liver | HCC | 2.91e-26 | 3.35e-02 | 0.0246 |
9941 | EXOG | HCC1 | Human | Liver | HCC | 7.06e-04 | 1.28e+00 | 0.5336 |
9941 | EXOG | HCC2 | Human | Liver | HCC | 2.62e-09 | 3.22e+00 | 0.5341 |
9941 | EXOG | S029 | Human | Liver | HCC | 2.25e-02 | 2.10e-01 | 0.2581 |
9941 | EXOG | PTC01 | Human | Thyroid | PTC | 2.42e-06 | 1.47e-01 | 0.1899 |
9941 | EXOG | PTC04 | Human | Thyroid | PTC | 1.02e-04 | 1.04e-01 | 0.1927 |
9941 | EXOG | PTC05 | Human | Thyroid | PTC | 9.71e-11 | 3.63e-01 | 0.2065 |
9941 | EXOG | PTC06 | Human | Thyroid | PTC | 6.91e-14 | 3.28e-01 | 0.2057 |
9941 | EXOG | PTC07 | Human | Thyroid | PTC | 3.28e-13 | 2.39e-01 | 0.2044 |
9941 | EXOG | ATC09 | Human | Thyroid | ATC | 1.94e-02 | 1.06e-01 | 0.2871 |
9941 | EXOG | ATC11 | Human | Thyroid | ATC | 8.01e-13 | 6.62e-01 | 0.3386 |
9941 | EXOG | ATC12 | Human | Thyroid | ATC | 5.78e-15 | 3.01e-01 | 0.34 |
9941 | EXOG | ATC13 | Human | Thyroid | ATC | 5.67e-13 | 2.20e-01 | 0.34 |
9941 | EXOG | ATC1 | Human | Thyroid | ATC | 5.84e-03 | 1.28e-01 | 0.2878 |
9941 | EXOG | ATC2 | Human | Thyroid | ATC | 8.49e-03 | 2.28e-01 | 0.34 |
9941 | EXOG | ATC3 | Human | Thyroid | ATC | 1.74e-16 | 7.42e-01 | 0.338 |
9941 | EXOG | ATC4 | Human | Thyroid | ATC | 1.65e-17 | 3.70e-01 | 0.34 |
9941 | EXOG | ATC5 | Human | Thyroid | ATC | 5.36e-16 | 2.43e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:00905015 | Thyroid | PTC | RNA phosphodiester bond hydrolysis | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
GO:00903055 | Thyroid | PTC | nucleic acid phosphodiester bond hydrolysis | 105/5968 | 261/18723 | 2.53e-03 | 1.31e-02 | 105 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:003465525 | Thyroid | ATC | nucleobase-containing compound catabolic process | 217/6293 | 407/18723 | 1.20e-16 | 1.04e-14 | 217 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOG | SNV | Missense_Mutation | novel | c.677C>T | p.Ser226Leu | p.S226L | Q9Y2C4 | protein_coding | deleterious(0) | possibly_damaging(0.783) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
EXOG | SNV | Missense_Mutation | rs371616022 | c.265N>T | p.Arg89Trp | p.R89W | Q9Y2C4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EXOG | SNV | Missense_Mutation | novel | c.770G>T | p.Gly257Val | p.G257V | Q9Y2C4 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
EXOG | insertion | Frame_Shift_Ins | novel | c.102_103insC | p.Ala35ArgfsTer11 | p.A35Rfs*11 | Q9Y2C4 | protein_coding | TCGA-D8-A1JE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamicin | SD | ||
EXOG | SNV | Missense_Mutation | novel | c.92C>A | p.Ala31Asp | p.A31D | Q9Y2C4 | protein_coding | deleterious(0.03) | benign(0.112) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EXOG | SNV | Missense_Mutation | rs368056983 | c.724G>A | p.Glu242Lys | p.E242K | Q9Y2C4 | protein_coding | tolerated(0.19) | benign(0.222) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EXOG | SNV | Missense_Mutation | novel | c.439N>C | p.Asn147His | p.N147H | Q9Y2C4 | protein_coding | tolerated(0.13) | possibly_damaging(0.573) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EXOG | SNV | Missense_Mutation | rs570781004 | c.959N>A | p.Arg320Gln | p.R320Q | Q9Y2C4 | protein_coding | deleterious(0.03) | benign(0.398) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EXOG | SNV | Missense_Mutation | novel | c.647N>C | p.Val216Ala | p.V216A | Q9Y2C4 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EXOG | SNV | Missense_Mutation | novel | c.446N>G | p.Phe149Cys | p.F149C | Q9Y2C4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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