Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ETV7

Gene summary for ETV7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ETV7

Gene ID

51513

Gene nameETS variant transcription factor 7
Gene AliasTEL-2
Cytomap6p21.31
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q9Y603


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51513ETV7LZE8THumanEsophagusESCC1.11e-021.50e-010.067
51513ETV7LZE20THumanEsophagusESCC1.59e-052.75e-010.0662
51513ETV7LZE24THumanEsophagusESCC3.10e-124.21e-010.0596
51513ETV7P2T-EHumanEsophagusESCC9.86e-345.95e-010.1177
51513ETV7P4T-EHumanEsophagusESCC3.74e-113.04e-010.1323
51513ETV7P5T-EHumanEsophagusESCC2.06e-082.03e-010.1327
51513ETV7P8T-EHumanEsophagusESCC1.00e-244.63e-010.0889
51513ETV7P9T-EHumanEsophagusESCC2.17e-276.30e-010.1131
51513ETV7P11T-EHumanEsophagusESCC2.55e-104.72e-010.1426
51513ETV7P12T-EHumanEsophagusESCC1.97e-102.57e-010.1122
51513ETV7P15T-EHumanEsophagusESCC5.50e-144.14e-010.1149
51513ETV7P16T-EHumanEsophagusESCC1.96e-057.80e-020.1153
51513ETV7P17T-EHumanEsophagusESCC1.22e-094.23e-010.1278
51513ETV7P21T-EHumanEsophagusESCC9.53e-092.34e-010.1617
51513ETV7P22T-EHumanEsophagusESCC3.97e-041.13e-010.1236
51513ETV7P23T-EHumanEsophagusESCC2.59e-185.65e-010.108
51513ETV7P24T-EHumanEsophagusESCC3.02e-265.69e-010.1287
51513ETV7P26T-EHumanEsophagusESCC9.02e-112.22e-010.1276
51513ETV7P27T-EHumanEsophagusESCC2.39e-244.14e-010.1055
51513ETV7P28T-EHumanEsophagusESCC2.27e-214.08e-010.1149
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ETV7IMENTColorectumMSSGBP4,BATF2,STAT1, etc.4.42e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7NKTPancreasADJAC025171.3,IL12RB2,GBP5, etc.4.03e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7NKTPancreasPanINAC025171.3,IL12RB2,GBP5, etc.1.10e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7TREGPancreasPDACAC025171.3,IL12RB2,GBP5, etc.1.53e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7NKTPancreasPDACAC025171.3,IL12RB2,GBP5, etc.9.87e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7APCAFPancreasADJPLCG2,GBP1,PLAAT4, etc.2.36e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7MSCPancreasHealthyPLCG2,GBP1,PLAAT4, etc.3.23e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ETV7PTCThyroidATCC1orf167,RARRES3,NPTX2, etc.3.59e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ETV7SNVMissense_Mutationnovelc.755N>Cp.Ile252Thrp.I252TQ9Y603protein_codingdeleterious(0)probably_damaging(0.937)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
ETV7insertionFrame_Shift_Insnovelc.710_711insGGGATGTGGTp.Arg238GlyfsTer6p.R238Gfs*6Q9Y603protein_codingTCGA-BH-A0BR-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.773C>Tp.Pro258Leup.P258LQ9Y603protein_codingdeleterious(0)probably_damaging(1)TCGA-AA-A029-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.38N>Ap.Pro13Hisp.P13HQ9Y603protein_codingdeleterious(0.02)possibly_damaging(0.62)TCGA-D5-6928-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationrs768642185c.851N>Ap.Arg284Hisp.R284HQ9Y603protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.827N>Gp.Tyr276Cysp.Y276CQ9Y603protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.370N>Gp.Pro124Alap.P124AQ9Y603protein_codingdeleterious(0.04)benign(0.03)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.913C>Ap.Leu305Ilep.L305IQ9Y603protein_codingdeleterious(0.01)probably_damaging(0.966)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationnovelc.143G>Ap.Arg48Hisp.R48HQ9Y603protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ETV7SNVMissense_Mutationrs750289065c.661N>Ap.Ala221Thrp.A221TQ9Y603protein_codingdeleterious(0.05)possibly_damaging(0.449)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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