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Gene: ESM1 |
Gene summary for ESM1 |
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Gene information | Species | Human | Gene symbol | ESM1 | Gene ID | 11082 |
Gene name | endothelial cell specific molecule 1 | |
Gene Alias | endocan | |
Cytomap | 5q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9NQ30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11082 | ESM1 | ATC11 | Human | Thyroid | ATC | 7.49e-03 | 5.69e-01 | 0.3386 |
11082 | ESM1 | ATC13 | Human | Thyroid | ATC | 5.84e-60 | 2.10e+00 | 0.34 |
11082 | ESM1 | ATC5 | Human | Thyroid | ATC | 5.60e-61 | 2.17e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004801212 | Thyroid | ATC | hepatocyte growth factor receptor signaling pathway | 12/6293 | 13/18723 | 1.85e-05 | 1.69e-04 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESM1 | SNV | Missense_Mutation | novel | c.274T>C | p.Phe92Leu | p.F92L | Q9NQ30 | protein_coding | tolerated(0.05) | probably_damaging(0.952) | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
ESM1 | SNV | Missense_Mutation | c.379N>A | p.Gly127Arg | p.G127R | Q9NQ30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ESM1 | SNV | Missense_Mutation | rs367904025 | c.449N>T | p.Thr150Met | p.T150M | Q9NQ30 | protein_coding | tolerated(0.07) | possibly_damaging(0.65) | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
ESM1 | SNV | Missense_Mutation | c.490G>A | p.Glu164Lys | p.E164K | Q9NQ30 | protein_coding | tolerated(0.05) | probably_damaging(0.98) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ESM1 | SNV | Missense_Mutation | c.202N>G | p.Thr68Ala | p.T68A | Q9NQ30 | protein_coding | tolerated(0.08) | probably_damaging(0.992) | TCGA-DM-A1D6-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESM1 | SNV | Missense_Mutation | c.371N>A | p.Arg124Lys | p.R124K | Q9NQ30 | protein_coding | tolerated(0.12) | benign(0.018) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
ESM1 | SNV | Missense_Mutation | rs201100866 | c.377C>T | p.Thr126Met | p.T126M | Q9NQ30 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ESM1 | SNV | Missense_Mutation | rs367904025 | c.449N>T | p.Thr150Met | p.T150M | Q9NQ30 | protein_coding | tolerated(0.07) | possibly_damaging(0.65) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD |
ESM1 | insertion | Nonsense_Mutation | novel | c.409_410insCCACATCTTATTCTACTCACAGATATTTTCTAAGTTATTCACACTGAAATTCCCCTTCTTCCAAT | p.Tyr137SerfsTer16 | p.Y137Sfs*16 | Q9NQ30 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ESM1 | SNV | Missense_Mutation | novel | c.175N>A | p.Ala59Thr | p.A59T | Q9NQ30 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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