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Gene: ESD |
Gene summary for ESD |
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Gene information | Species | Human | Gene symbol | ESD | Gene ID | 2098 |
Gene name | esterase D | |
Gene Alias | FGH | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006081 | UniProtAcc | A0A140VJJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2098 | ESD | HTA11_78_2000001011 | Human | Colorectum | AD | 1.71e-04 | 5.45e-01 | -0.1088 |
2098 | ESD | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.68e-13 | 9.54e-01 | 0.281 |
2098 | ESD | A015-C-203 | Human | Colorectum | FAP | 1.15e-09 | -2.14e-01 | -0.1294 |
2098 | ESD | A002-C-201 | Human | Colorectum | FAP | 5.93e-04 | -1.79e-01 | 0.0324 |
2098 | ESD | A001-C-119 | Human | Colorectum | FAP | 4.08e-06 | -2.65e-01 | -0.1557 |
2098 | ESD | A001-C-108 | Human | Colorectum | FAP | 1.11e-06 | -1.82e-01 | -0.0272 |
2098 | ESD | A002-C-205 | Human | Colorectum | FAP | 9.89e-06 | -1.26e-01 | -0.1236 |
2098 | ESD | A001-C-104 | Human | Colorectum | FAP | 6.22e-06 | -1.60e-01 | 0.0184 |
2098 | ESD | A015-C-005 | Human | Colorectum | FAP | 1.59e-03 | -2.16e-01 | -0.0336 |
2098 | ESD | A015-C-006 | Human | Colorectum | FAP | 2.20e-03 | -1.82e-01 | -0.0994 |
2098 | ESD | A015-C-106 | Human | Colorectum | FAP | 5.58e-03 | -1.20e-01 | -0.0511 |
2098 | ESD | A002-C-114 | Human | Colorectum | FAP | 8.12e-05 | -1.99e-01 | -0.1561 |
2098 | ESD | A015-C-104 | Human | Colorectum | FAP | 2.01e-10 | -2.02e-01 | -0.1899 |
2098 | ESD | A001-C-014 | Human | Colorectum | FAP | 2.30e-11 | -2.15e-01 | 0.0135 |
2098 | ESD | A002-C-016 | Human | Colorectum | FAP | 1.02e-07 | -1.81e-01 | 0.0521 |
2098 | ESD | A015-C-002 | Human | Colorectum | FAP | 2.67e-03 | -2.44e-01 | -0.0763 |
2098 | ESD | A001-C-203 | Human | Colorectum | FAP | 6.62e-08 | -1.48e-01 | -0.0481 |
2098 | ESD | A002-C-116 | Human | Colorectum | FAP | 2.19e-11 | -1.79e-01 | -0.0452 |
2098 | ESD | A014-C-008 | Human | Colorectum | FAP | 2.49e-03 | -1.95e-01 | -0.191 |
2098 | ESD | A018-E-020 | Human | Colorectum | FAP | 1.27e-04 | -1.76e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0097237 | Colorectum | AD | cellular response to toxic substance | 44/3918 | 124/18723 | 1.24e-04 | 1.80e-03 | 44 |
GO:1990748 | Colorectum | AD | cellular detoxification | 41/3918 | 116/18723 | 2.29e-04 | 2.97e-03 | 41 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
GO:00972372 | Colorectum | MSS | cellular response to toxic substance | 37/3467 | 124/18723 | 1.47e-03 | 1.36e-02 | 37 |
GO:00060811 | Colorectum | MSS | cellular aldehyde metabolic process | 21/3467 | 60/18723 | 1.81e-03 | 1.60e-02 | 21 |
GO:19907482 | Colorectum | MSS | cellular detoxification | 34/3467 | 116/18723 | 3.08e-03 | 2.34e-02 | 34 |
GO:00987542 | Colorectum | MSS | detoxification | 41/3467 | 152/18723 | 6.41e-03 | 4.27e-02 | 41 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:00096363 | Colorectum | FAP | response to toxic substance | 53/2622 | 262/18723 | 3.35e-03 | 2.46e-02 | 53 |
GO:009723710 | Endometrium | AEH | cellular response to toxic substance | 34/2100 | 124/18723 | 5.02e-07 | 1.97e-05 | 34 |
GO:199074810 | Endometrium | AEH | cellular detoxification | 30/2100 | 116/18723 | 8.40e-06 | 1.98e-04 | 30 |
GO:000963610 | Endometrium | AEH | response to toxic substance | 52/2100 | 262/18723 | 2.89e-05 | 5.40e-04 | 52 |
GO:009875410 | Endometrium | AEH | detoxification | 31/2100 | 152/18723 | 6.85e-04 | 6.62e-03 | 31 |
GO:009723715 | Endometrium | EEC | cellular response to toxic substance | 35/2168 | 124/18723 | 3.44e-07 | 1.37e-05 | 35 |
GO:199074815 | Endometrium | EEC | cellular detoxification | 31/2168 | 116/18723 | 5.54e-06 | 1.36e-04 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa012004 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa012005 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa012006 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa012007 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa012008 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa012009 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0120021 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa0120031 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa0120041 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0120051 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0120014 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa0120015 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa0120022 | Oral cavity | LP | Carbon metabolism | 62/2418 | 115/8465 | 8.38e-09 | 1.39e-07 | 8.99e-08 | 62 |
hsa0120032 | Oral cavity | LP | Carbon metabolism | 62/2418 | 115/8465 | 8.38e-09 | 1.39e-07 | 8.99e-08 | 62 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESD | SNV | Missense_Mutation | c.511G>C | p.Ala171Pro | p.A171P | P10768 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
ESD | SNV | Missense_Mutation | c.51N>C | p.Lys17Asn | p.K17N | P10768 | protein_coding | tolerated(0.14) | benign(0.287) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD | |
ESD | SNV | Missense_Mutation | novel | c.640N>G | p.Ser214Ala | p.S214A | P10768 | protein_coding | tolerated(0.46) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ESD | SNV | Missense_Mutation | novel | c.106N>G | p.Leu36Val | p.L36V | P10768 | protein_coding | tolerated(0.07) | benign(0.251) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ESD | SNV | Missense_Mutation | c.292N>C | p.Asp98His | p.D98H | P10768 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D5-5538-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium | PD | |
ESD | SNV | Missense_Mutation | c.50N>G | p.Lys17Arg | p.K17R | P10768 | protein_coding | tolerated(0.48) | benign(0.041) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ESD | SNV | Missense_Mutation | c.782G>A | p.Ser261Asn | p.S261N | P10768 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESD | deletion | Frame_Shift_Del | c.438delT | p.Phe146LeufsTer11 | p.F146Lfs*11 | P10768 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
ESD | SNV | Missense_Mutation | novel | c.274N>T | p.Gly92Cys | p.G92C | P10768 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ESD | SNV | Missense_Mutation | novel | c.710A>G | p.Asp237Gly | p.D237G | P10768 | protein_coding | deleterious(0.03) | benign(0.041) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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