|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ESAM |
Gene summary for ESAM |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ESAM | Gene ID | 90952 |
| Gene name | endothelial cell adhesion molecule | |
| Gene Alias | W117m | |
| Cytomap | 11q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q96AP7 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 90952 | ESAM | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.50e-02 | -5.16e-01 | -0.2116 |
| 90952 | ESAM | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.87e-08 | -6.49e-01 | -0.0166 |
| 90952 | ESAM | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.62e-07 | -6.26e-01 | -0.0132 |
| 90952 | ESAM | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.24e-07 | -5.88e-01 | -0.013 |
| 90952 | ESAM | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.40e-08 | -6.49e-01 | -0.0121 |
| 90952 | ESAM | Adj_PTCwithHT_6 | Human | Thyroid | HT | 7.75e-12 | -5.02e-01 | 0.02 |
| 90952 | ESAM | PTCwithHT_6 | Human | Thyroid | HT | 5.58e-12 | -4.79e-01 | 0.02 |
| 90952 | ESAM | PTCwithHT_8 | Human | Thyroid | HT | 1.65e-04 | -4.05e-01 | 0.0351 |
| 90952 | ESAM | PTCwithoutHT_2 | Human | Thyroid | PTC | 2.41e-07 | -4.55e-01 | 0.0419 |
| 90952 | ESAM | male-WTA | Human | Thyroid | PTC | 2.60e-34 | -1.80e-01 | 0.1037 |
| 90952 | ESAM | PTC01 | Human | Thyroid | PTC | 3.97e-13 | -2.61e-01 | 0.1899 |
| 90952 | ESAM | PTC04 | Human | Thyroid | PTC | 9.71e-10 | -8.20e-02 | 0.1927 |
| 90952 | ESAM | PTC05 | Human | Thyroid | PTC | 2.43e-08 | -2.09e-01 | 0.2065 |
| 90952 | ESAM | PTC06 | Human | Thyroid | PTC | 1.22e-12 | -4.39e-02 | 0.2057 |
| 90952 | ESAM | PTC07 | Human | Thyroid | PTC | 1.61e-16 | 5.36e-02 | 0.2044 |
| 90952 | ESAM | ATC08 | Human | Thyroid | ATC | 5.83e-04 | -5.37e-01 | 0.0541 |
| 90952 | ESAM | ATC09 | Human | Thyroid | ATC | 4.27e-04 | -4.04e-01 | 0.2871 |
| 90952 | ESAM | ATC12 | Human | Thyroid | ATC | 6.20e-14 | -5.28e-01 | 0.34 |
| 90952 | ESAM | ATC13 | Human | Thyroid | ATC | 7.08e-22 | -5.17e-01 | 0.34 |
| 90952 | ESAM | ATC1 | Human | Thyroid | ATC | 4.46e-06 | -4.32e-01 | 0.2878 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00070158 | Lung | IAC | actin filament organization | 92/2061 | 442/18723 | 1.01e-09 | 1.93e-07 | 92 |
| GO:00315327 | Lung | IAC | actin cytoskeleton reorganization | 35/2061 | 107/18723 | 1.44e-09 | 2.38e-07 | 35 |
| GO:00343297 | Lung | IAC | cell junction assembly | 86/2061 | 420/18723 | 7.98e-09 | 1.10e-06 | 86 |
| GO:00329708 | Lung | IAC | regulation of actin filament-based process | 77/2061 | 397/18723 | 4.85e-07 | 3.10e-05 | 77 |
| GO:00329568 | Lung | IAC | regulation of actin cytoskeleton organization | 70/2061 | 358/18723 | 1.17e-06 | 6.20e-05 | 70 |
| GO:19029038 | Lung | IAC | regulation of supramolecular fiber organization | 73/2061 | 383/18723 | 1.87e-06 | 8.87e-05 | 73 |
| GO:00452168 | Lung | IAC | cell-cell junction organization | 43/2061 | 200/18723 | 1.21e-05 | 3.64e-04 | 43 |
| GO:01100538 | Lung | IAC | regulation of actin filament organization | 54/2061 | 278/18723 | 2.27e-05 | 6.28e-04 | 54 |
| GO:00432977 | Lung | IAC | apical junction assembly | 22/2061 | 78/18723 | 2.31e-05 | 6.34e-04 | 22 |
| GO:00512588 | Lung | IAC | protein polymerization | 56/2061 | 297/18723 | 3.90e-05 | 9.51e-04 | 56 |
| GO:01201926 | Lung | IAC | tight junction assembly | 20/2061 | 74/18723 | 1.03e-04 | 2.02e-03 | 20 |
| GO:01201936 | Lung | IAC | tight junction organization | 21/2061 | 80/18723 | 1.11e-04 | 2.14e-03 | 21 |
| GO:00070438 | Lung | IAC | cell-cell junction assembly | 31/2061 | 146/18723 | 2.38e-04 | 4.06e-03 | 31 |
| GO:00325357 | Lung | IAC | regulation of cellular component size | 65/2061 | 383/18723 | 2.56e-04 | 4.26e-03 | 65 |
| GO:00708305 | Lung | IAC | bicellular tight junction assembly | 18/2061 | 70/18723 | 4.40e-04 | 6.51e-03 | 18 |
| GO:00322718 | Lung | IAC | regulation of protein polymerization | 42/2061 | 233/18723 | 8.87e-04 | 1.11e-02 | 42 |
| GO:00356334 | Lung | IAC | maintenance of blood-brain barrier | 11/2061 | 35/18723 | 9.48e-04 | 1.15e-02 | 11 |
| GO:00432548 | Lung | IAC | regulation of protein-containing complex assembly | 68/2061 | 428/18723 | 1.20e-03 | 1.38e-02 | 68 |
| GO:00018947 | Lung | IAC | tissue homeostasis | 46/2061 | 268/18723 | 1.50e-03 | 1.60e-02 | 46 |
| GO:00602497 | Lung | IAC | anatomical structure homeostasis | 51/2061 | 314/18723 | 2.91e-03 | 2.61e-02 | 51 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa045146 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
| hsa0451411 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
| hsa0467023 | Lung | AIS | Leukocyte transendothelial migration | 29/961 | 114/8465 | 1.92e-05 | 4.08e-04 | 2.61e-04 | 29 |
| hsa0467033 | Lung | AIS | Leukocyte transendothelial migration | 29/961 | 114/8465 | 1.92e-05 | 4.08e-04 | 2.61e-04 | 29 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| ESAM | ESAM | ESAM_ESAM | ESAM | Breast | ADJ |
| ESAM | ESAM | ESAM_ESAM | ESAM | Breast | DCIS |
| ESAM | ESAM | ESAM_ESAM | ESAM | Breast | Healthy |
| ESAM | ESAM | ESAM_ESAM | ESAM | Breast | IDC |
| ESAM | ESAM | ESAM_ESAM | ESAM | Breast | Precancer |
| ESAM | ESAM | ESAM_ESAM | ESAM | Cervix | ADJ |
| ESAM | ESAM | ESAM_ESAM | ESAM | Cervix | CC |
| ESAM | ESAM | ESAM_ESAM | ESAM | Cervix | Healthy |
| ESAM | ESAM | ESAM_ESAM | ESAM | Cervix | Precancer |
| ESAM | ESAM | ESAM_ESAM | ESAM | CRC | AD |
| ESAM | ESAM | ESAM_ESAM | ESAM | CRC | MSI-H |
| ESAM | ESAM | ESAM_ESAM | ESAM | CRC | MSS |
| ESAM | ESAM | ESAM_ESAM | ESAM | CRC | SER |
| ESAM | ESAM | ESAM_ESAM | ESAM | Endometrium | ADJ |
| ESAM | ESAM | ESAM_ESAM | ESAM | Endometrium | AEH |
| ESAM | ESAM | ESAM_ESAM | ESAM | Endometrium | EEC |
| ESAM | ESAM | ESAM_ESAM | ESAM | Endometrium | Healthy |
| ESAM | ESAM | ESAM_ESAM | ESAM | Esophagus | ESCC |
| ESAM | ESAM | ESAM_ESAM | ESAM | Esophagus | Healthy |
| ESAM | ESAM | ESAM_ESAM | ESAM | GC | ADJ |
| Page: 1 2 3 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ESAM | SNV | Missense_Mutation | c.394G>A | p.Asp132Asn | p.D132N | Q96AP7 | protein_coding | tolerated(0.12) | benign(0.034) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ESAM | SNV | Missense_Mutation | novel | c.132G>T | p.Glu44Asp | p.E44D | Q96AP7 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ESAM | SNV | Missense_Mutation | c.935N>T | p.Ser312Phe | p.S312F | Q96AP7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
| ESAM | deletion | Frame_Shift_Del | novel | c.626delN | p.Leu209Ter | p.L209* | Q96AP7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| ESAM | SNV | Missense_Mutation | c.1036A>G | p.Arg346Gly | p.R346G | Q96AP7 | protein_coding | tolerated(0.37) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ESAM | SNV | Missense_Mutation | c.514N>A | p.Leu172Met | p.L172M | Q96AP7 | protein_coding | tolerated(0.13) | possibly_damaging(0.737) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
| ESAM | SNV | Missense_Mutation | c.698N>T | p.Ala233Val | p.A233V | Q96AP7 | protein_coding | deleterious(0.01) | possibly_damaging(0.624) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ESAM | SNV | Missense_Mutation | rs759294805 | c.878N>A | p.Arg293Gln | p.R293Q | Q96AP7 | protein_coding | deleterious(0.01) | possibly_damaging(0.852) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
| ESAM | SNV | Missense_Mutation | novel | c.923N>T | p.Gly308Val | p.G308V | Q96AP7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ESAM | SNV | Missense_Mutation | novel | c.407A>C | p.Lys136Thr | p.K136T | Q96AP7 | protein_coding | tolerated(0.92) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |