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Gene: ERMARD |
Gene summary for ERMARD |
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Gene information | Species | Human | Gene symbol | ERMARD | Gene ID | 55780 |
Gene name | ER membrane associated RNA degradation | |
Gene Alias | C6orf70 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q5T6L9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55780 | ERMARD | LZE24T | Human | Esophagus | ESCC | 6.57e-07 | 1.43e-01 | 0.0596 |
55780 | ERMARD | P1T-E | Human | Esophagus | ESCC | 1.82e-02 | 1.95e-01 | 0.0875 |
55780 | ERMARD | P2T-E | Human | Esophagus | ESCC | 1.81e-08 | 9.68e-02 | 0.1177 |
55780 | ERMARD | P5T-E | Human | Esophagus | ESCC | 3.06e-10 | 9.61e-02 | 0.1327 |
55780 | ERMARD | P8T-E | Human | Esophagus | ESCC | 2.84e-11 | 9.23e-02 | 0.0889 |
55780 | ERMARD | P9T-E | Human | Esophagus | ESCC | 2.39e-04 | 8.06e-02 | 0.1131 |
55780 | ERMARD | P10T-E | Human | Esophagus | ESCC | 5.58e-12 | 7.04e-02 | 0.116 |
55780 | ERMARD | P12T-E | Human | Esophagus | ESCC | 1.69e-03 | 4.49e-02 | 0.1122 |
55780 | ERMARD | P15T-E | Human | Esophagus | ESCC | 2.77e-02 | 8.37e-02 | 0.1149 |
55780 | ERMARD | P16T-E | Human | Esophagus | ESCC | 3.23e-13 | 1.75e-01 | 0.1153 |
55780 | ERMARD | P20T-E | Human | Esophagus | ESCC | 3.83e-02 | 8.71e-02 | 0.1124 |
55780 | ERMARD | P21T-E | Human | Esophagus | ESCC | 7.22e-09 | 1.43e-01 | 0.1617 |
55780 | ERMARD | P22T-E | Human | Esophagus | ESCC | 2.48e-04 | 4.90e-02 | 0.1236 |
55780 | ERMARD | P23T-E | Human | Esophagus | ESCC | 5.02e-05 | 1.51e-01 | 0.108 |
55780 | ERMARD | P24T-E | Human | Esophagus | ESCC | 1.56e-07 | 8.19e-02 | 0.1287 |
55780 | ERMARD | P26T-E | Human | Esophagus | ESCC | 2.05e-12 | 1.34e-01 | 0.1276 |
55780 | ERMARD | P27T-E | Human | Esophagus | ESCC | 6.49e-17 | 1.05e-01 | 0.1055 |
55780 | ERMARD | P28T-E | Human | Esophagus | ESCC | 1.06e-10 | 9.28e-02 | 0.1149 |
55780 | ERMARD | P30T-E | Human | Esophagus | ESCC | 8.17e-11 | 2.41e-01 | 0.137 |
55780 | ERMARD | P31T-E | Human | Esophagus | ESCC | 6.24e-12 | 9.80e-02 | 0.1251 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERMARD | SNV | Missense_Mutation | novel | c.439N>C | p.Glu147Gln | p.E147Q | Q5T6L9 | protein_coding | deleterious(0.02) | possibly_damaging(0.864) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ERMARD | SNV | Missense_Mutation | c.1051N>T | p.Pro351Ser | p.P351S | Q5T6L9 | protein_coding | tolerated(0.11) | benign(0.079) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ERMARD | SNV | Missense_Mutation | c.307N>G | p.Phe103Val | p.F103V | Q5T6L9 | protein_coding | tolerated(0.52) | benign(0) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
ERMARD | SNV | Missense_Mutation | c.529N>A | p.Val177Ile | p.V177I | Q5T6L9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-E2-A1LK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ERMARD | insertion | In_Frame_Ins | novel | c.849_850insGAATGTGCTAAAAGTCTTCGT | p.Lys283_Ser284insGluCysAlaLysSerLeuArg | p.K283_S284insECAKSLR | Q5T6L9 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
ERMARD | deletion | Frame_Shift_Del | novel | c.1491delN | p.Lys498ArgfsTer59 | p.K498Rfs*59 | Q5T6L9 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ERMARD | SNV | Missense_Mutation | rs765374947 | c.287C>T | p.Pro96Leu | p.P96L | Q5T6L9 | protein_coding | tolerated(0.97) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ERMARD | SNV | Missense_Mutation | novel | c.571C>T | p.His191Tyr | p.H191Y | Q5T6L9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ERMARD | SNV | Missense_Mutation | novel | c.1316A>G | p.Gln439Arg | p.Q439R | Q5T6L9 | protein_coding | deleterious(0.02) | benign(0.335) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ERMARD | SNV | Missense_Mutation | c.1743N>G | p.Ile581Met | p.I581M | Q5T6L9 | protein_coding | tolerated(0.15) | benign(0.123) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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