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Gene: ERICH5 |
Gene summary for ERICH5 |
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Gene information | Species | Human | Gene symbol | ERICH5 | Gene ID | 203111 |
Gene name | glutamate rich 5 | |
Gene Alias | C8orf47 | |
Cytomap | 8q22.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6P6B1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203111 | ERICH5 | S43 | Human | Liver | Cirrhotic | 1.31e-08 | -2.06e-01 | -0.0187 |
203111 | ERICH5 | HCC1_Meng | Human | Liver | HCC | 7.05e-70 | 1.01e-02 | 0.0246 |
203111 | ERICH5 | HCC2_Meng | Human | Liver | HCC | 6.25e-23 | -3.73e-02 | 0.0107 |
203111 | ERICH5 | cirrhotic1 | Human | Liver | Cirrhotic | 2.14e-16 | 3.33e-01 | 0.0202 |
203111 | ERICH5 | cirrhotic2 | Human | Liver | Cirrhotic | 3.40e-13 | 2.00e-01 | 0.0201 |
203111 | ERICH5 | cirrhotic3 | Human | Liver | Cirrhotic | 3.45e-09 | 9.99e-02 | 0.0215 |
203111 | ERICH5 | HCC2 | Human | Liver | HCC | 2.06e-03 | 1.82e+00 | 0.5341 |
203111 | ERICH5 | Pt13.a | Human | Liver | HCC | 2.20e-10 | -2.69e-01 | 0.021 |
203111 | ERICH5 | Pt13.b | Human | Liver | HCC | 2.63e-03 | -2.69e-01 | 0.0251 |
203111 | ERICH5 | Pt14.d | Human | Liver | HCC | 1.01e-10 | -2.69e-01 | 0.0143 |
203111 | ERICH5 | S014 | Human | Liver | HCC | 3.63e-02 | -2.69e-01 | 0.2254 |
203111 | ERICH5 | S016 | Human | Liver | HCC | 4.83e-02 | -2.52e-01 | 0.2243 |
203111 | ERICH5 | S027 | Human | Liver | HCC | 4.80e-05 | 8.06e-01 | 0.2446 |
203111 | ERICH5 | S028 | Human | Liver | HCC | 5.32e-26 | 1.25e+00 | 0.2503 |
203111 | ERICH5 | S029 | Human | Liver | HCC | 8.15e-25 | 1.39e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERICH5 | SNV | Missense_Mutation | novel | c.244N>A | p.Gln82Lys | p.Q82K | Q6P6B1 | protein_coding | tolerated(0.22) | benign(0.022) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ERICH5 | SNV | Missense_Mutation | c.415N>A | p.Glu139Lys | p.E139K | Q6P6B1 | protein_coding | deleterious(0.03) | benign(0.062) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ERICH5 | SNV | Missense_Mutation | c.779N>T | p.Arg260Ile | p.R260I | Q6P6B1 | protein_coding | tolerated(0.18) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ERICH5 | SNV | Missense_Mutation | c.814N>C | p.Asp272His | p.D272H | Q6P6B1 | protein_coding | deleterious(0.04) | possibly_damaging(0.73) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
ERICH5 | SNV | Missense_Mutation | novel | c.491N>T | p.Ala164Val | p.A164V | Q6P6B1 | protein_coding | tolerated(0.2) | benign(0.147) | TCGA-ZJ-AAXJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ERICH5 | SNV | Missense_Mutation | novel | c.700A>C | p.Ser234Arg | p.S234R | Q6P6B1 | protein_coding | tolerated(0.11) | benign(0.031) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ERICH5 | SNV | Missense_Mutation | c.1067G>T | p.Gly356Val | p.G356V | Q6P6B1 | protein_coding | tolerated(0.07) | probably_damaging(0.956) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ERICH5 | SNV | Missense_Mutation | novel | c.853C>T | p.Pro285Ser | p.P285S | Q6P6B1 | protein_coding | tolerated(0.68) | benign(0) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ERICH5 | SNV | Missense_Mutation | rs762941709 | c.938N>A | p.Arg313Gln | p.R313Q | Q6P6B1 | protein_coding | deleterious(0.02) | benign(0.039) | TCGA-AG-3999-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unspecific | PD | |
ERICH5 | SNV | Missense_Mutation | c.425N>A | p.Ser142Tyr | p.S142Y | Q6P6B1 | protein_coding | deleterious(0) | benign(0.005) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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