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Gene: ERICH2 |
Gene summary for ERICH2 |
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Gene information | Species | Human | Gene symbol | ERICH2 | Gene ID | 285141 |
Gene name | glutamate rich 2 | |
Gene Alias | ERICH2 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A1L162 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285141 | ERICH2 | HCC1_Meng | Human | Liver | HCC | 2.35e-30 | 4.50e-02 | 0.0246 |
285141 | ERICH2 | HCC1 | Human | Liver | HCC | 3.50e-02 | 1.78e+00 | 0.5336 |
285141 | ERICH2 | HCC2 | Human | Liver | HCC | 1.42e-07 | 2.45e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERICH2 | SNV | Missense_Mutation | novel | c.112G>A | p.Glu38Lys | p.E38K | A1L162 | protein_coding | tolerated(0.15) | benign(0.01) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ERICH2 | deletion | Frame_Shift_Del | novel | c.261delA | p.Lys87AsnfsTer5 | p.K87Nfs*5 | A1L162 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
ERICH2 | insertion | Frame_Shift_Ins | rs765922748 | c.261dupA | p.Leu88IlefsTer9 | p.L88Ifs*9 | A1L162 | protein_coding | TCGA-EA-A556-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ERICH2 | SNV | Missense_Mutation | novel | c.194C>T | p.Ala65Val | p.A65V | A1L162 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ERICH2 | SNV | Missense_Mutation | novel | c.188C>T | p.Thr63Ile | p.T63I | A1L162 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERICH2 | SNV | Missense_Mutation | novel | c.152N>G | p.Glu51Gly | p.E51G | A1L162 | protein_coding | deleterious(0.01) | benign(0.009) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ERICH2 | insertion | Frame_Shift_Ins | rs765922748 | c.254_255insA | p.Leu88IlefsTer9 | p.L88Ifs*9 | A1L162 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ERICH2 | SNV | Missense_Mutation | novel | c.188C>A | p.Thr63Asn | p.T63N | A1L162 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ERICH2 | SNV | Missense_Mutation | novel | c.154G>T | p.Asp52Tyr | p.D52Y | A1L162 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERICH2 | SNV | Missense_Mutation | novel | c.348G>T | p.Glu116Asp | p.E116D | A1L162 | protein_coding | tolerated(0.1) | probably_damaging(0.992) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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