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Gene: ERG |
Gene summary for ERG |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ERG | Gene ID | 2078 |
| Gene name | ETS transcription factor ERG | |
| Gene Alias | erg-3 | |
| Cytomap | 21q22.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DN83 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2078 | ERG | CCI_1 | Human | Cervix | CC | 3.26e-19 | 1.43e+00 | 0.528 |
| 2078 | ERG | CCI_3 | Human | Cervix | CC | 2.05e-05 | 5.74e-01 | 0.516 |
| 2078 | ERG | AEH-subject3 | Human | Endometrium | AEH | 6.69e-03 | 2.01e-01 | -0.2576 |
| 2078 | ERG | AEH-subject5 | Human | Endometrium | AEH | 3.86e-07 | 2.38e-01 | -0.2953 |
| 2078 | ERG | EEC-subject1 | Human | Endometrium | EEC | 4.91e-06 | 3.11e-01 | -0.2682 |
| 2078 | ERG | EEC-subject4 | Human | Endometrium | EEC | 1.12e-05 | 2.20e-01 | -0.2571 |
| 2078 | ERG | EEC-subject5 | Human | Endometrium | EEC | 2.11e-07 | 3.41e-01 | -0.249 |
| 2078 | ERG | GSM5276935 | Human | Endometrium | EEC | 3.40e-05 | 1.52e-01 | -0.123 |
| 2078 | ERG | P5T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.58e-01 | 0.1327 |
| 2078 | ERG | P9T-E | Human | Esophagus | ESCC | 2.05e-02 | 1.60e-01 | 0.1131 |
| 2078 | ERG | P10T-E | Human | Esophagus | ESCC | 3.75e-03 | 6.36e-02 | 0.116 |
| 2078 | ERG | P11T-E | Human | Esophagus | ESCC | 3.15e-03 | 1.84e-01 | 0.1426 |
| 2078 | ERG | P12T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.12e-01 | 0.1122 |
| 2078 | ERG | P20T-E | Human | Esophagus | ESCC | 2.28e-02 | 1.25e-01 | 0.1124 |
| 2078 | ERG | P26T-E | Human | Esophagus | ESCC | 5.03e-37 | 6.08e-01 | 0.1276 |
| 2078 | ERG | P27T-E | Human | Esophagus | ESCC | 3.60e-13 | 3.02e-01 | 0.1055 |
| 2078 | ERG | P28T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.15e-01 | 0.1149 |
| 2078 | ERG | P30T-E | Human | Esophagus | ESCC | 1.53e-02 | 1.24e-01 | 0.137 |
| 2078 | ERG | P32T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.42e-02 | 0.1666 |
| 2078 | ERG | P37T-E | Human | Esophagus | ESCC | 3.41e-03 | 1.20e-01 | 0.1371 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00068906 | Breast | IDC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 10/1434 | 52/18723 | 5.49e-03 | 4.03e-02 | 10 |
| GO:000689012 | Breast | DCIS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 10/1390 | 52/18723 | 4.41e-03 | 3.41e-02 | 10 |
| GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
| GO:00063684 | Cervix | CC | transcription elongation from RNA polymerase II promoter | 17/2311 | 69/18723 | 3.65e-03 | 2.33e-02 | 17 |
| GO:00063545 | Cervix | CC | DNA-templated transcription, elongation | 20/2311 | 91/18723 | 6.88e-03 | 3.74e-02 | 20 |
| GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
| GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
| GO:0006890 | Colorectum | AD | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/3918 | 52/18723 | 7.67e-07 | 2.70e-05 | 27 |
| GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
| GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
| GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
| GO:0006368 | Colorectum | AD | transcription elongation from RNA polymerase II promoter | 24/3918 | 69/18723 | 5.35e-03 | 3.52e-02 | 24 |
| GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
| GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
| GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
| GO:00068901 | Colorectum | SER | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 20/2897 | 52/18723 | 4.80e-05 | 1.18e-03 | 20 |
| GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
| GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
| GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
| GO:00068902 | Colorectum | MSS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 26/3467 | 52/18723 | 2.66e-07 | 1.10e-05 | 26 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
| hsa0521512 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
| hsa052158 | Endometrium | AEH | Prostate cancer | 25/1197 | 97/8465 | 1.68e-03 | 1.01e-02 | 7.39e-03 | 25 |
| hsa0521513 | Endometrium | AEH | Prostate cancer | 25/1197 | 97/8465 | 1.68e-03 | 1.01e-02 | 7.39e-03 | 25 |
| hsa0521522 | Endometrium | EEC | Prostate cancer | 25/1237 | 97/8465 | 2.66e-03 | 1.56e-02 | 1.16e-02 | 25 |
| hsa0521532 | Endometrium | EEC | Prostate cancer | 25/1237 | 97/8465 | 2.66e-03 | 1.56e-02 | 1.16e-02 | 25 |
| hsa0521516 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
| hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
| hsa0521517 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
| hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ERG | MYOEPI | Breast | ADJ | AL590617.2,ITGA2,DST, etc. | 6.58e-01 |  |
| ERG | MYOEPI | Breast | Healthy | ITGB1,LIMA1,NRP2, etc. | 4.72e-01 |  |
| ERG | MYOEPI | Breast | Precancer | AL590617.2,ITGA2,DST, etc. | 6.16e-01 |  |
| ERG | STM | Cervix | Healthy | CYSLTR1,TPST2,DOP1B, etc. | 3.44e-01 |  |
| ERG | SPI | Oral cavity | NEOLP | PROX1,ST6GALNAC3,STOX2, etc. | 1.83e-01 |  |
| ERG | MAST | Pancreas | ADJ | KCNG2,EPB41L1,KIT, etc. | 1.87e-01 |  |
| ERG | MAST | Pancreas | Healthy | KCNG2,EPB41L1,KIT, etc. | 2.65e-01 |  |
| ERG | MAST | Pancreas | PanIN | KCNG2,EPB41L1,KIT, etc. | 4.60e-01 |  |
| ERG | MAST | Pancreas | PDAC | KCNG2,EPB41L1,KIT, etc. | 3.19e-01 |  |
| ERG | NKT | Pancreas | PDAC | KCNG2,EPB41L1,KIT, etc. | 9.03e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ERG | SNV | Missense_Mutation | c.465N>T | p.Lys155Asn | p.K155N | P11308 | protein_coding | deleterious(0.04) | probably_damaging(0.966) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
| ERG | SNV | Missense_Mutation | novel | c.976N>A | p.Glu326Lys | p.E326K | P11308 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| ERG | SNV | Missense_Mutation | c.1267C>A | p.Pro423Thr | p.P423T | P11308 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-A2-A1FX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
| ERG | SNV | Missense_Mutation | novel | c.29N>T | p.Ala10Val | p.A10V | P11308 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ERG | SNV | Missense_Mutation | c.120N>A | p.Met40Ile | p.M40I | P11308 | protein_coding | deleterious(0.05) | benign(0.358) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| ERG | SNV | Missense_Mutation | c.401T>A | p.Val134Glu | p.V134E | P11308 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-GM-A2DF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
| ERG | insertion | Frame_Shift_Ins | novel | c.1309_1310insCA | p.Phe437SerfsTer12 | p.F437Sfs*12 | P11308 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ERG | insertion | Nonsense_Mutation | novel | c.1307_1308insACAATCTGGAGATGTTACAAGTTTATGACTCATGA | p.Asn436LysfsTer10 | p.N436Kfs*10 | P11308 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ERG | SNV | Missense_Mutation | c.1123N>A | p.Ala375Thr | p.A375T | P11308 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ERG | SNV | Missense_Mutation | c.749G>T | p.Arg250Ile | p.R250I | P11308 | protein_coding | deleterious(0.02) | possibly_damaging(0.866) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | MMV009085 | CHEMBL581225 | ||
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | MEDROXYPROGESTERONE ACETATE | MEDROXYPROGESTERONE ACETATE | ||
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | blocker | CHEMBL473 | DOFETILIDE | |
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | HOMIDIUM BROMIDE | HOMIDIUM BROMIDE | ||
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | blocker | CHEMBL1700 | SOTALOL HYDROCHLORIDE | |
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | blocker | CHEMBL3545169 | AZD1305 | |
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | GNF-PF-1947 | CHEMBL585591 | ||
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | blocker | CHEMBL2107762 | NERISPIRDINE | |
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | ACRIDIN-1-YLAMINE | CHEMBL146525 | ||
| 2078 | ERG | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | IDARUBICIN HYDROCHLORIDE | IDARUBICIN HYDROCHLORIDE |
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