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Gene: ERBB2IP |
Gene summary for ERBB2IP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ERBB2IP | Gene ID | 55914 |
| Gene name | erbb2 interacting protein | |
| Gene Alias | ERBB2IP | |
| Cytomap | 5q12.3 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q96RT1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55914 | ERBB2IP | P1T-E | Human | Esophagus | ESCC | 3.50e-13 | 5.41e-01 | 0.0875 |
| 55914 | ERBB2IP | P2T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.57e-01 | 0.1177 |
| 55914 | ERBB2IP | P4T-E | Human | Esophagus | ESCC | 7.21e-12 | 2.54e-01 | 0.1323 |
| 55914 | ERBB2IP | P5T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.88e-01 | 0.1327 |
| 55914 | ERBB2IP | P8T-E | Human | Esophagus | ESCC | 3.95e-30 | 4.96e-01 | 0.0889 |
| 55914 | ERBB2IP | P9T-E | Human | Esophagus | ESCC | 6.89e-11 | 2.78e-01 | 0.1131 |
| 55914 | ERBB2IP | P10T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.12e-01 | 0.116 |
| 55914 | ERBB2IP | P11T-E | Human | Esophagus | ESCC | 3.97e-24 | 6.63e-01 | 0.1426 |
| 55914 | ERBB2IP | P12T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.83e-01 | 0.1122 |
| 55914 | ERBB2IP | P15T-E | Human | Esophagus | ESCC | 1.83e-30 | 5.31e-01 | 0.1149 |
| 55914 | ERBB2IP | P16T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.72e-01 | 0.1153 |
| 55914 | ERBB2IP | P17T-E | Human | Esophagus | ESCC | 4.48e-07 | 2.84e-01 | 0.1278 |
| 55914 | ERBB2IP | P19T-E | Human | Esophagus | ESCC | 3.75e-07 | 4.63e-01 | 0.1662 |
| 55914 | ERBB2IP | P20T-E | Human | Esophagus | ESCC | 2.46e-20 | 3.85e-01 | 0.1124 |
| 55914 | ERBB2IP | P21T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.63e-01 | 0.1617 |
| 55914 | ERBB2IP | P22T-E | Human | Esophagus | ESCC | 2.86e-20 | 3.39e-01 | 0.1236 |
| 55914 | ERBB2IP | P23T-E | Human | Esophagus | ESCC | 4.70e-20 | 3.88e-01 | 0.108 |
| 55914 | ERBB2IP | P24T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.67e-01 | 0.1287 |
| 55914 | ERBB2IP | P26T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.49e-01 | 0.1276 |
| 55914 | ERBB2IP | P27T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.81e-01 | 0.1055 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa046213 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
| hsa0462112 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
| hsa046212 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
| hsa0462111 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
| hsa046214 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
| hsa046215 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
| hsa046216 | Oral cavity | NEOLP | NOD-like receptor signaling pathway | 39/1112 | 186/8465 | 1.79e-03 | 7.91e-03 | 4.98e-03 | 39 |
| hsa046217 | Oral cavity | NEOLP | NOD-like receptor signaling pathway | 39/1112 | 186/8465 | 1.79e-03 | 7.91e-03 | 4.98e-03 | 39 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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