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Gene: ERAL1 |
Gene summary for ERAL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ERAL1 | Gene ID | 26284 |
| Gene name | Era like 12S mitochondrial rRNA chaperone 1 | |
| Gene Alias | CEGA | |
| Cytomap | 17q11.2 | |
| Gene Type | protein-coding | GO ID | GO:0000028 | UniProtAcc | O75616 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26284 | ERAL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.61e-02 | 1.61e-01 | -0.1808 |
| 26284 | ERAL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.14e-04 | 2.42e-01 | -0.0811 |
| 26284 | ERAL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.35e-06 | 2.03e-01 | -0.1954 |
| 26284 | ERAL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.85e-02 | 2.01e-01 | -0.1207 |
| 26284 | ERAL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.57e-03 | 2.05e-01 | -0.1464 |
| 26284 | ERAL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.40e-04 | 2.64e-01 | -0.059 |
| 26284 | ERAL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.26e-04 | 1.83e-01 | 0.096 |
| 26284 | ERAL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.10e-03 | 2.57e-01 | 0.0338 |
| 26284 | ERAL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.09e-03 | 2.27e-01 | 0.0674 |
| 26284 | ERAL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.79e-03 | 1.82e-01 | 0.294 |
| 26284 | ERAL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.61e-06 | 3.25e-01 | 0.3859 |
| 26284 | ERAL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.77e-03 | 1.96e-01 | 0.2585 |
| 26284 | ERAL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.47e-10 | 3.19e-01 | 0.3005 |
| 26284 | ERAL1 | LZE4T | Human | Esophagus | ESCC | 3.14e-06 | 3.57e-01 | 0.0811 |
| 26284 | ERAL1 | LZE5T | Human | Esophagus | ESCC | 5.24e-03 | 4.07e-01 | 0.0514 |
| 26284 | ERAL1 | LZE7T | Human | Esophagus | ESCC | 4.17e-06 | 4.33e-01 | 0.0667 |
| 26284 | ERAL1 | LZE8T | Human | Esophagus | ESCC | 5.78e-12 | 3.75e-01 | 0.067 |
| 26284 | ERAL1 | LZE20T | Human | Esophagus | ESCC | 1.82e-05 | 9.48e-02 | 0.0662 |
| 26284 | ERAL1 | LZE24T | Human | Esophagus | ESCC | 8.61e-20 | 6.88e-01 | 0.0596 |
| 26284 | ERAL1 | LZE21T | Human | Esophagus | ESCC | 4.02e-04 | 5.99e-01 | 0.0655 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
| GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
| GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
| GO:0042255 | Colorectum | AD | ribosome assembly | 28/3918 | 61/18723 | 1.08e-05 | 2.47e-04 | 28 |
| GO:0000028 | Colorectum | AD | ribosomal small subunit assembly | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
| GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
| GO:0042274 | Colorectum | AD | ribosomal small subunit biogenesis | 25/3918 | 73/18723 | 5.69e-03 | 3.64e-02 | 25 |
| GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
| GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
| GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
| GO:00422551 | Colorectum | SER | ribosome assembly | 25/2897 | 61/18723 | 1.44e-06 | 6.55e-05 | 25 |
| GO:00000281 | Colorectum | SER | ribosomal small subunit assembly | 10/2897 | 19/18723 | 1.86e-04 | 3.43e-03 | 10 |
| GO:00422741 | Colorectum | SER | ribosomal small subunit biogenesis | 23/2897 | 73/18723 | 4.50e-04 | 6.57e-03 | 23 |
| GO:00422541 | Colorectum | SER | ribosome biogenesis | 66/2897 | 299/18723 | 1.48e-03 | 1.60e-02 | 66 |
| GO:00718262 | Colorectum | MSS | ribonucleoprotein complex subunit organization | 90/3467 | 227/18723 | 6.88e-14 | 1.78e-11 | 90 |
| GO:00226182 | Colorectum | MSS | ribonucleoprotein complex assembly | 88/3467 | 220/18723 | 7.12e-14 | 1.78e-11 | 88 |
| GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
| GO:00422552 | Colorectum | MSS | ribosome assembly | 26/3467 | 61/18723 | 1.15e-05 | 2.71e-04 | 26 |
| GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
| GO:00000282 | Colorectum | MSS | ribosomal small subunit assembly | 10/3467 | 19/18723 | 8.39e-04 | 8.68e-03 | 10 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ERAL1 | SNV | Missense_Mutation | c.554N>T | p.Ser185Phe | p.S185F | O75616 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
| ERAL1 | SNV | Missense_Mutation | novel | c.281N>C | p.Arg94Thr | p.R94T | O75616 | protein_coding | tolerated(0.05) | benign(0.118) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
| ERAL1 | insertion | In_Frame_Ins | novel | c.1144_1145insCTTGTTCAATCGGTGTTA | p.Glu382delinsAlaCysSerIleGlyValLys | p.E382delinsACSIGVK | O75616 | protein_coding | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| ERAL1 | insertion | In_Frame_Ins | novel | c.272_273insGATTTCTGCTATTTGGCCTCATGGGAAATGTAGTCTTTTAGGAGA | p.Ser91_Met92insIleSerAlaIleTrpProHisGlyLysCysSerLeuLeuGlyAsp | p.S91_M92insISAIWPHGKCSLLGD | O75616 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ERAL1 | insertion | Frame_Shift_Ins | novel | c.214_215insCTTTTAGGAGACATGGCCAGAAGGGCCGTTTACA | p.His72ProfsTer36 | p.H72Pfs*36 | O75616 | protein_coding | TCGA-B6-A0IC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ERAL1 | insertion | Frame_Shift_Ins | novel | c.222_223insTCTCCTACTCGCT | p.Gly75SerfsTer26 | p.G75Sfs*26 | O75616 | protein_coding | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
| ERAL1 | SNV | Missense_Mutation | c.176C>T | p.Ser59Leu | p.S59L | O75616 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ERAL1 | SNV | Missense_Mutation | c.187N>T | p.Ser63Cys | p.S63C | O75616 | protein_coding | tolerated_low_confidence(0.11) | benign(0) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ERAL1 | SNV | Missense_Mutation | c.931C>A | p.Leu311Ile | p.L311I | O75616 | protein_coding | tolerated(0.13) | benign(0.296) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ERAL1 | SNV | Missense_Mutation | c.432G>T | p.Lys144Asn | p.K144N | O75616 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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