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Gene: EPSTI1 |
Gene summary for EPSTI1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | EPSTI1 | Gene ID | 94240 |
Gene name | epithelial stromal interaction 1 | |
Gene Alias | BRESI1 | |
Cytomap | 13q14.11 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96J88 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94240 | EPSTI1 | CA_HPV_1 | Human | Cervix | CC | 4.40e-17 | 5.80e-01 | 0.0264 |
94240 | EPSTI1 | CA_HPV_2 | Human | Cervix | CC | 1.48e-04 | 3.28e-01 | 0.0391 |
94240 | EPSTI1 | CCI_2 | Human | Cervix | CC | 1.38e-09 | 1.39e+00 | 0.5249 |
94240 | EPSTI1 | sample1 | Human | Cervix | CC | 7.76e-04 | 3.99e-01 | 0.0959 |
94240 | EPSTI1 | T1 | Human | Cervix | CC | 8.50e-04 | 2.90e-01 | 0.0918 |
94240 | EPSTI1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.97e-03 | 4.40e-01 | -0.059 |
94240 | EPSTI1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.28e-02 | 2.38e-01 | 0.096 |
94240 | EPSTI1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.74e-07 | 4.33e-01 | 0.294 |
94240 | EPSTI1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.34e-05 | 6.00e-01 | 0.281 |
94240 | EPSTI1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.18e-25 | 9.16e-01 | 0.3859 |
94240 | EPSTI1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.86e-13 | 1.05e+00 | 0.2585 |
94240 | EPSTI1 | F072B | Human | Colorectum | FAP | 1.55e-11 | 6.28e-01 | 0.257 |
94240 | EPSTI1 | CRC-1-8810 | Human | Colorectum | CRC | 3.45e-08 | 5.00e-01 | 0.6257 |
94240 | EPSTI1 | LZE4T | Human | Esophagus | ESCC | 4.54e-02 | 1.71e-01 | 0.0811 |
94240 | EPSTI1 | LZE8T | Human | Esophagus | ESCC | 4.94e-04 | 1.78e-01 | 0.067 |
94240 | EPSTI1 | LZE20T | Human | Esophagus | ESCC | 1.28e-06 | 3.97e-01 | 0.0662 |
94240 | EPSTI1 | LZE22T | Human | Esophagus | ESCC | 6.64e-03 | 2.97e-01 | 0.068 |
94240 | EPSTI1 | LZE24T | Human | Esophagus | ESCC | 4.61e-26 | 9.57e-01 | 0.0596 |
94240 | EPSTI1 | LZE6T | Human | Esophagus | ESCC | 1.60e-08 | 4.40e-01 | 0.0845 |
94240 | EPSTI1 | P1T-E | Human | Esophagus | ESCC | 1.41e-04 | 3.87e-01 | 0.0875 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPSTI1 | insertion | Frame_Shift_Ins | novel | c.466_467insA | p.Met156AsnfsTer11 | p.M156Nfs*11 | Q96J88 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EPSTI1 | SNV | Missense_Mutation | novel | c.944G>A | p.Ser315Asn | p.S315N | Q96J88 | protein_coding | deleterious(0.02) | possibly_damaging(0.866) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EPSTI1 | SNV | Missense_Mutation | c.750G>C | p.Lys250Asn | p.K250N | Q96J88 | protein_coding | deleterious(0.01) | possibly_damaging(0.732) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
EPSTI1 | SNV | Missense_Mutation | c.825N>C | p.Lys275Asn | p.K275N | Q96J88 | protein_coding | deleterious(0.01) | possibly_damaging(0.59) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
EPSTI1 | SNV | Missense_Mutation | novel | c.230N>T | p.Arg77Ile | p.R77I | Q96J88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EPSTI1 | SNV | Missense_Mutation | novel | c.425N>C | p.Val142Ala | p.V142A | Q96J88 | protein_coding | tolerated(0.31) | benign(0.006) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EPSTI1 | SNV | Missense_Mutation | c.314N>C | p.Leu105Pro | p.L105P | Q96J88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPSTI1 | SNV | Missense_Mutation | novel | c.230N>T | p.Arg77Ile | p.R77I | Q96J88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EPSTI1 | SNV | Missense_Mutation | c.673N>T | p.Pro225Ser | p.P225S | Q96J88 | protein_coding | tolerated(0.21) | benign(0.011) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EPSTI1 | SNV | Missense_Mutation | c.20N>C | p.Val7Ala | p.V7A | Q96J88 | protein_coding | tolerated_low_confidence(0.06) | benign(0.046) | TCGA-DM-A285-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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