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Gene: EPS8L3 |
Gene summary for EPS8L3 |
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Gene information | Species | Human | Gene symbol | EPS8L3 | Gene ID | 79574 |
Gene name | EPS8 like 3 | |
Gene Alias | EPS8R3 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8TE67 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79574 | EPS8L3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.76e-04 | 4.42e-01 | -0.1808 |
79574 | EPS8L3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.17e-06 | 4.96e-01 | -0.0811 |
79574 | EPS8L3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.14e-08 | 3.99e-01 | -0.1954 |
79574 | EPS8L3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.83e-05 | 1.05e+00 | -0.2602 |
79574 | EPS8L3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.26e-03 | 4.23e-01 | -0.1207 |
79574 | EPS8L3 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.03e-03 | 2.80e-01 | -0.1526 |
79574 | EPS8L3 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.42e-04 | 3.74e-01 | -0.1464 |
79574 | EPS8L3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.00e-15 | 7.50e-01 | -0.059 |
79574 | EPS8L3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.13e-04 | 5.41e-01 | 0.3859 |
79574 | EPS8L3 | A015-C-203 | Human | Colorectum | FAP | 2.13e-10 | 1.16e-01 | -0.1294 |
79574 | EPS8L3 | A001-C-108 | Human | Colorectum | FAP | 2.07e-03 | 4.67e-02 | -0.0272 |
79574 | EPS8L3 | A002-C-205 | Human | Colorectum | FAP | 1.74e-04 | 4.49e-02 | -0.1236 |
79574 | EPS8L3 | A015-C-006 | Human | Colorectum | FAP | 9.48e-04 | 2.51e-02 | -0.0994 |
79574 | EPS8L3 | A015-C-106 | Human | Colorectum | FAP | 2.52e-02 | 1.60e-01 | -0.0511 |
79574 | EPS8L3 | A002-C-114 | Human | Colorectum | FAP | 8.93e-05 | 1.06e-01 | -0.1561 |
79574 | EPS8L3 | A015-C-104 | Human | Colorectum | FAP | 4.27e-11 | 8.25e-02 | -0.1899 |
79574 | EPS8L3 | A001-C-014 | Human | Colorectum | FAP | 5.99e-03 | -1.87e-02 | 0.0135 |
79574 | EPS8L3 | A002-C-016 | Human | Colorectum | FAP | 6.73e-08 | -9.60e-02 | 0.0521 |
79574 | EPS8L3 | A002-C-116 | Human | Colorectum | FAP | 2.46e-12 | -1.58e-01 | -0.0452 |
79574 | EPS8L3 | A014-C-008 | Human | Colorectum | FAP | 4.99e-02 | 1.06e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:0120034 | Colorectum | AD | positive regulation of plasma membrane bounded cell projection assembly | 33/3918 | 105/18723 | 7.49e-03 | 4.55e-02 | 33 |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:00313461 | Colorectum | SER | positive regulation of cell projection organization | 75/2897 | 353/18723 | 2.22e-03 | 2.14e-02 | 75 |
GO:01200321 | Colorectum | SER | regulation of plasma membrane bounded cell projection assembly | 43/2897 | 186/18723 | 3.82e-03 | 3.16e-02 | 43 |
GO:0060491 | Colorectum | SER | regulation of cell projection assembly | 43/2897 | 188/18723 | 4.68e-03 | 3.70e-02 | 43 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:00604911 | Colorectum | MSS | regulation of cell projection assembly | 51/3467 | 188/18723 | 2.28e-03 | 1.87e-02 | 51 |
GO:01200341 | Colorectum | MSS | positive regulation of plasma membrane bounded cell projection assembly | 30/3467 | 105/18723 | 7.74e-03 | 4.84e-02 | 30 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00313463 | Colorectum | FAP | positive regulation of cell projection organization | 82/2622 | 353/18723 | 1.78e-06 | 7.35e-05 | 82 |
GO:00465781 | Colorectum | FAP | regulation of Ras protein signal transduction | 47/2622 | 189/18723 | 4.67e-05 | 9.60e-04 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPS8L3 | SNV | Missense_Mutation | c.595N>A | p.Leu199Ile | p.L199I | Q8TE67 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
EPS8L3 | SNV | Missense_Mutation | novel | c.358N>A | p.Gly120Ser | p.G120S | Q8TE67 | protein_coding | tolerated(0.25) | benign(0.067) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EPS8L3 | SNV | Missense_Mutation | novel | c.961T>C | p.Ser321Pro | p.S321P | Q8TE67 | protein_coding | deleterious(0.03) | benign(0.093) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EPS8L3 | deletion | Frame_Shift_Del | novel | c.1374_1384delNNNNNNNNNNN | p.Leu459Ter | p.L459* | Q8TE67 | protein_coding | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | ||
EPS8L3 | SNV | Missense_Mutation | rs753148902 | c.275G>A | p.Arg92His | p.R92H | Q8TE67 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EPS8L3 | SNV | Missense_Mutation | c.1167C>A | p.Phe389Leu | p.F389L | Q8TE67 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EPS8L3 | SNV | Missense_Mutation | c.1167C>A | p.Phe389Leu | p.F389L | Q8TE67 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EPS8L3 | SNV | Missense_Mutation | rs772599226 | c.1684N>T | p.Arg562Cys | p.R562C | Q8TE67 | protein_coding | deleterious(0.01) | benign(0.401) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
EPS8L3 | SNV | Missense_Mutation | c.536T>A | p.Met179Lys | p.M179K | Q8TE67 | protein_coding | tolerated(0.87) | benign(0) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EPS8L3 | SNV | Missense_Mutation | rs527350018 | c.1564C>T | p.Arg522Trp | p.R522W | Q8TE67 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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