Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: EPS8L3

Gene summary for EPS8L3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

EPS8L3

Gene ID

79574

Gene nameEPS8 like 3
Gene AliasEPS8R3
Cytomap1p13.3
Gene Typeprotein-coding
GO ID

GO:0007154

UniProtAcc

Q8TE67


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
79574EPS8L3HTA11_2487_2000001011HumanColorectumSER4.76e-044.42e-01-0.1808
79574EPS8L3HTA11_1938_2000001011HumanColorectumAD3.17e-064.96e-01-0.0811
79574EPS8L3HTA11_347_2000001011HumanColorectumAD1.14e-083.99e-01-0.1954
79574EPS8L3HTA11_411_2000001011HumanColorectumSER1.83e-051.05e+00-0.2602
79574EPS8L3HTA11_3361_2000001011HumanColorectumAD2.26e-034.23e-01-0.1207
79574EPS8L3HTA11_83_2000001011HumanColorectumSER8.03e-032.80e-01-0.1526
79574EPS8L3HTA11_696_2000001011HumanColorectumAD8.42e-043.74e-01-0.1464
79574EPS8L3HTA11_1391_2000001011HumanColorectumAD1.00e-157.50e-01-0.059
79574EPS8L3HTA11_99999971662_82457HumanColorectumMSS2.13e-045.41e-010.3859
79574EPS8L3A015-C-203HumanColorectumFAP2.13e-101.16e-01-0.1294
79574EPS8L3A001-C-108HumanColorectumFAP2.07e-034.67e-02-0.0272
79574EPS8L3A002-C-205HumanColorectumFAP1.74e-044.49e-02-0.1236
79574EPS8L3A015-C-006HumanColorectumFAP9.48e-042.51e-02-0.0994
79574EPS8L3A015-C-106HumanColorectumFAP2.52e-021.60e-01-0.0511
79574EPS8L3A002-C-114HumanColorectumFAP8.93e-051.06e-01-0.1561
79574EPS8L3A015-C-104HumanColorectumFAP4.27e-118.25e-02-0.1899
79574EPS8L3A001-C-014HumanColorectumFAP5.99e-03-1.87e-020.0135
79574EPS8L3A002-C-016HumanColorectumFAP6.73e-08-9.60e-020.0521
79574EPS8L3A002-C-116HumanColorectumFAP2.46e-12-1.58e-01-0.0452
79574EPS8L3A014-C-008HumanColorectumFAP4.99e-021.06e-01-0.191
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0007265ColorectumADRas protein signal transduction104/3918337/187231.01e-052.35e-04104
GO:0051056ColorectumADregulation of small GTPase mediated signal transduction94/3918302/187231.81e-053.76e-0494
GO:0031346ColorectumADpositive regulation of cell projection organization104/3918353/187238.26e-051.30e-03104
GO:0046578ColorectumADregulation of Ras protein signal transduction56/3918189/187232.85e-032.14e-0256
GO:0007266ColorectumADRho protein signal transduction42/3918137/187234.64e-033.16e-0242
GO:0120034ColorectumADpositive regulation of plasma membrane bounded cell projection assembly33/3918105/187237.49e-034.55e-0233
GO:0120032ColorectumADregulation of plasma membrane bounded cell projection assembly53/3918186/187238.51e-034.97e-0253
GO:00313461ColorectumSERpositive regulation of cell projection organization75/2897353/187232.22e-032.14e-0275
GO:01200321ColorectumSERregulation of plasma membrane bounded cell projection assembly43/2897186/187233.82e-033.16e-0243
GO:0060491ColorectumSERregulation of cell projection assembly43/2897188/187234.68e-033.70e-0243
GO:00313462ColorectumMSSpositive regulation of cell projection organization96/3467353/187233.44e-056.70e-0496
GO:00072651ColorectumMSSRas protein signal transduction91/3467337/187237.20e-051.21e-0391
GO:00510561ColorectumMSSregulation of small GTPase mediated signal transduction82/3467302/187231.31e-041.99e-0382
GO:01200322ColorectumMSSregulation of plasma membrane bounded cell projection assembly51/3467186/187231.78e-031.58e-0251
GO:00604911ColorectumMSSregulation of cell projection assembly51/3467188/187232.28e-031.87e-0251
GO:01200341ColorectumMSSpositive regulation of plasma membrane bounded cell projection assembly30/3467105/187237.74e-034.84e-0230
GO:00510562ColorectumFAPregulation of small GTPase mediated signal transduction78/2622302/187233.25e-082.85e-0678
GO:00072652ColorectumFAPRas protein signal transduction80/2622337/187239.61e-074.33e-0580
GO:00313463ColorectumFAPpositive regulation of cell projection organization82/2622353/187231.78e-067.35e-0582
GO:00465781ColorectumFAPregulation of Ras protein signal transduction47/2622189/187234.67e-059.60e-0447
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
EPS8L3SNVMissense_Mutationc.595N>Ap.Leu199Ilep.L199IQ8TE67protein_codingtolerated(0.14)benign(0.003)TCGA-A1-A0SO-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapySD
EPS8L3SNVMissense_Mutationnovelc.358N>Ap.Gly120Serp.G120SQ8TE67protein_codingtolerated(0.25)benign(0.067)TCGA-A8-A08R-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
EPS8L3SNVMissense_Mutationnovelc.961T>Cp.Ser321Prop.S321PQ8TE67protein_codingdeleterious(0.03)benign(0.093)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
EPS8L3deletionFrame_Shift_Delnovelc.1374_1384delNNNNNNNNNNNp.Leu459Terp.L459*Q8TE67protein_codingTCGA-A7-A4SE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
EPS8L3SNVMissense_Mutationrs753148902c.275G>Ap.Arg92Hisp.R92HQ8TE67protein_codingtolerated(0.2)benign(0.003)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
EPS8L3SNVMissense_Mutationc.1167C>Ap.Phe389Leup.F389LQ8TE67protein_codingtolerated(0.05)benign(0.015)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
EPS8L3SNVMissense_Mutationc.1167C>Ap.Phe389Leup.F389LQ8TE67protein_codingtolerated(0.05)benign(0.015)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
EPS8L3SNVMissense_Mutationrs772599226c.1684N>Tp.Arg562Cysp.R562CQ8TE67protein_codingdeleterious(0.01)benign(0.401)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
EPS8L3SNVMissense_Mutationc.536T>Ap.Met179Lysp.M179KQ8TE67protein_codingtolerated(0.87)benign(0)TCGA-AA-A02R-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
EPS8L3SNVMissense_Mutationrs527350018c.1564C>Tp.Arg522Trpp.R522WQ8TE67protein_codingtolerated(0.09)benign(0.015)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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