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Gene: ENTHD2 |
Gene summary for ENTHD2 |
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Gene information | Species | Human | Gene symbol | ENTHD2 | Gene ID | 146705 |
Gene name | TEPSIN adaptor related protein complex 4 accessory protein | |
Gene Alias | C17orf56 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96N21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146705 | ENTHD2 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.84e-01 | 0.0875 |
146705 | ENTHD2 | P2T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.12e-01 | 0.1177 |
146705 | ENTHD2 | P5T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.20e-01 | 0.1327 |
146705 | ENTHD2 | P8T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.98e-01 | 0.0889 |
146705 | ENTHD2 | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.01e-01 | 0.1131 |
146705 | ENTHD2 | P10T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.96e-01 | 0.116 |
146705 | ENTHD2 | P11T-E | Human | Esophagus | ESCC | 1.06e-12 | 4.28e-01 | 0.1426 |
146705 | ENTHD2 | P12T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.65e-01 | 0.1122 |
146705 | ENTHD2 | P15T-E | Human | Esophagus | ESCC | 3.16e-13 | 2.90e-01 | 0.1149 |
146705 | ENTHD2 | P16T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.34e-01 | 0.1153 |
146705 | ENTHD2 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.90e-01 | 0.1278 |
146705 | ENTHD2 | P20T-E | Human | Esophagus | ESCC | 8.54e-43 | 7.40e-01 | 0.1124 |
146705 | ENTHD2 | P21T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.46e-01 | 0.1617 |
146705 | ENTHD2 | P22T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.36e-01 | 0.1236 |
146705 | ENTHD2 | P23T-E | Human | Esophagus | ESCC | 9.87e-03 | 1.03e-01 | 0.108 |
146705 | ENTHD2 | P24T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.56e-01 | 0.1287 |
146705 | ENTHD2 | P26T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.37e-01 | 0.1276 |
146705 | ENTHD2 | P27T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.24e-01 | 0.1055 |
146705 | ENTHD2 | P28T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.46e-01 | 0.1149 |
146705 | ENTHD2 | P30T-E | Human | Esophagus | ESCC | 6.12e-09 | 3.19e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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