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Gene: ENPP7 |
Gene summary for ENPP7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ENPP7 | Gene ID | 339221 |
| Gene name | ectonucleotide pyrophosphatase/phosphodiesterase 7 | |
| Gene Alias | ALK-SMase | |
| Cytomap | 17q25.3 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q6UWV6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 339221 | ENPP7 | Pat01-B | Human | Stomach | GC | 1.32e-16 | 4.20e-01 | 0.5754 |
| 339221 | ENPP7 | Pat03-B | Human | Stomach | GC | 4.97e-02 | 1.29e-01 | 0.3693 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007586 | Stomach | GC | digestion | 38/1159 | 137/18723 | 1.80e-15 | 1.22e-12 | 38 |
| GO:00226006 | Stomach | GC | digestive system process | 30/1159 | 104/18723 | 5.40e-13 | 2.10e-10 | 30 |
| GO:00508925 | Stomach | GC | intestinal absorption | 18/1159 | 41/18723 | 8.10e-12 | 2.20e-09 | 18 |
| GO:0098856 | Stomach | GC | intestinal lipid absorption | 10/1159 | 21/18723 | 1.50e-07 | 8.56e-06 | 10 |
| GO:00442424 | Stomach | GC | cellular lipid catabolic process | 32/1159 | 214/18723 | 3.16e-06 | 1.29e-04 | 32 |
| GO:00160425 | Stomach | GC | lipid catabolic process | 41/1159 | 320/18723 | 7.84e-06 | 2.80e-04 | 41 |
| GO:00342506 | Stomach | GC | positive regulation of cellular amide metabolic process | 25/1159 | 162/18723 | 2.12e-05 | 6.44e-04 | 25 |
| GO:0030299 | Stomach | GC | intestinal cholesterol absorption | 7/1159 | 18/18723 | 5.94e-05 | 1.35e-03 | 7 |
| GO:0055088 | Stomach | GC | lipid homeostasis | 24/1159 | 167/18723 | 9.86e-05 | 2.00e-03 | 24 |
| GO:00313316 | Stomach | GC | positive regulation of cellular catabolic process | 46/1159 | 427/18723 | 1.79e-04 | 3.12e-03 | 46 |
| GO:0044241 | Stomach | GC | lipid digestion | 7/1159 | 21/18723 | 1.84e-04 | 3.16e-03 | 7 |
| GO:0019216 | Stomach | GC | regulation of lipid metabolic process | 37/1159 | 331/18723 | 3.67e-04 | 5.70e-03 | 37 |
| GO:00098966 | Stomach | GC | positive regulation of catabolic process | 50/1159 | 492/18723 | 3.89e-04 | 5.97e-03 | 50 |
| GO:0046890 | Stomach | GC | regulation of lipid biosynthetic process | 22/1159 | 171/18723 | 8.94e-04 | 1.10e-02 | 22 |
| GO:0050996 | Stomach | GC | positive regulation of lipid catabolic process | 7/1159 | 28/18723 | 1.28e-03 | 1.44e-02 | 7 |
| GO:0030301 | Stomach | GC | cholesterol transport | 16/1159 | 117/18723 | 2.29e-03 | 2.21e-02 | 16 |
| GO:0015918 | Stomach | GC | sterol transport | 17/1159 | 130/18723 | 2.75e-03 | 2.53e-02 | 17 |
| GO:1904729 | Stomach | GC | regulation of intestinal lipid absorption | 4/1159 | 11/18723 | 3.39e-03 | 2.94e-02 | 4 |
| GO:1904478 | Stomach | GC | regulation of intestinal absorption | 4/1159 | 13/18723 | 6.65e-03 | 4.85e-02 | 4 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ENPP7 | SNV | Missense_Mutation | c.191N>A | p.Ala64Glu | p.A64E | Q6UWV6 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A2-A25D-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
| ENPP7 | SNV | Missense_Mutation | rs530922212 | c.695G>A | p.Arg232His | p.R232H | Q6UWV6 | protein_coding | tolerated(0.13) | benign(0.021) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
| ENPP7 | SNV | Missense_Mutation | novel | c.170T>C | p.Met57Thr | p.M57T | Q6UWV6 | protein_coding | deleterious(0.03) | benign(0.111) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ENPP7 | SNV | Missense_Mutation | novel | c.952G>T | p.Ala318Ser | p.A318S | Q6UWV6 | protein_coding | tolerated(0.62) | benign(0.003) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| ENPP7 | SNV | Missense_Mutation | c.524N>G | p.Asn175Ser | p.N175S | Q6UWV6 | protein_coding | tolerated(0.05) | benign(0.036) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ENPP7 | SNV | Missense_Mutation | rs782250551 | c.136N>C | p.Asp46His | p.D46H | Q6UWV6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
| ENPP7 | SNV | Missense_Mutation | c.1086G>A | p.Met362Ile | p.M362I | Q6UWV6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| ENPP7 | insertion | Frame_Shift_Ins | novel | c.1141_1142insACTCCCATTTACTCAGGGTCTGGTCT | p.Pro381HisfsTer35 | p.P381Hfs*35 | Q6UWV6 | protein_coding | TCGA-A8-A08O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | PD | ||
| ENPP7 | insertion | Frame_Shift_Ins | novel | c.354dupG | p.Trp119ValfsTer51 | p.W119Vfs*51 | Q6UWV6 | protein_coding | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| ENPP7 | deletion | Frame_Shift_Del | novel | c.1008delT | p.Gly337AlafsTer26 | p.G337Afs*26 | Q6UWV6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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