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Gene: EMID1 |
Gene summary for EMID1 |
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Gene information | Species | Human | Gene symbol | EMID1 | Gene ID | 129080 |
Gene name | EMI domain containing 1 | |
Gene Alias | EMI5 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96A84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129080 | EMID1 | P2T-E | Human | Esophagus | ESCC | 3.95e-30 | 4.57e-01 | 0.1177 |
129080 | EMID1 | P4T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.24e-01 | 0.1323 |
129080 | EMID1 | P8T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.39e-01 | 0.0889 |
129080 | EMID1 | P10T-E | Human | Esophagus | ESCC | 5.57e-40 | 7.10e-01 | 0.116 |
129080 | EMID1 | P16T-E | Human | Esophagus | ESCC | 3.65e-51 | 1.02e+00 | 0.1153 |
129080 | EMID1 | P22T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.70e-02 | 0.1236 |
129080 | EMID1 | P26T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.35e-01 | 0.1276 |
129080 | EMID1 | P27T-E | Human | Esophagus | ESCC | 3.97e-04 | 2.35e-01 | 0.1055 |
129080 | EMID1 | P28T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.04e-02 | 0.1149 |
129080 | EMID1 | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.70e-01 | 0.137 |
129080 | EMID1 | P56T-E | Human | Esophagus | ESCC | 5.84e-10 | 1.15e+00 | 0.1613 |
129080 | EMID1 | P65T-E | Human | Esophagus | ESCC | 1.06e-02 | 8.47e-02 | 0.0978 |
129080 | EMID1 | P74T-E | Human | Esophagus | ESCC | 6.89e-16 | 3.52e-01 | 0.1479 |
129080 | EMID1 | P76T-E | Human | Esophagus | ESCC | 7.98e-13 | 3.05e-01 | 0.1207 |
129080 | EMID1 | P79T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.72e-01 | 0.1154 |
129080 | EMID1 | P83T-E | Human | Esophagus | ESCC | 3.29e-10 | 2.56e-01 | 0.1738 |
129080 | EMID1 | P128T-E | Human | Esophagus | ESCC | 5.67e-04 | 1.53e-01 | 0.1241 |
129080 | EMID1 | P130T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.98e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMID1 | SNV | Missense_Mutation | rs761751973 | c.247N>T | p.Val83Leu | p.V83L | Q96A84 | protein_coding | tolerated(0.16) | probably_damaging(0.987) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
EMID1 | SNV | Missense_Mutation | c.236N>A | p.Pro79His | p.P79H | Q96A84 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
EMID1 | SNV | Missense_Mutation | c.829N>T | p.Pro277Ser | p.P277S | Q96A84 | protein_coding | tolerated(0.29) | benign(0.029) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
EMID1 | SNV | Missense_Mutation | rs555505087 | c.706N>T | p.Arg236Trp | p.R236W | Q96A84 | protein_coding | deleterious(0.03) | benign(0.257) | TCGA-AA-3681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EMID1 | SNV | Missense_Mutation | c.913N>A | p.Gly305Ser | p.G305S | Q96A84 | protein_coding | deleterious(0.04) | possibly_damaging(0.891) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EMID1 | SNV | Missense_Mutation | novel | c.218N>G | p.Tyr73Cys | p.Y73C | Q96A84 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
EMID1 | SNV | Missense_Mutation | c.871N>T | p.Pro291Ser | p.P291S | Q96A84 | protein_coding | tolerated(0.19) | possibly_damaging(0.528) | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
EMID1 | SNV | Missense_Mutation | rs201463222 | c.1036N>A | p.Arg346Ser | p.R346S | Q96A84 | protein_coding | deleterious(0.05) | benign(0.031) | TCGA-D5-6539-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EMID1 | SNV | Missense_Mutation | c.1216N>A | p.Gly406Arg | p.G406R | Q96A84 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EMID1 | SNV | Missense_Mutation | c.578N>T | p.Gly193Val | p.G193V | Q96A84 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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