![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EMCN |
Gene summary for EMCN |
![]() |
Gene information | Species | Human | Gene symbol | EMCN | Gene ID | 51705 |
Gene name | endomucin | |
Gene Alias | EMCN2 | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9ULC0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51705 | EMCN | HCC1 | Human | Liver | HCC | 5.99e-05 | 2.12e+00 | 0.5336 |
51705 | EMCN | HCC2 | Human | Liver | HCC | 9.72e-11 | 9.57e-01 | 0.5341 |
51705 | EMCN | HCC5 | Human | Liver | HCC | 4.30e-19 | 9.93e-01 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004887222 | Liver | HCC | homeostasis of number of cells | 147/7958 | 272/18723 | 7.48e-05 | 6.70e-04 | 147 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMCN | SNV | Missense_Mutation | rs201510590 | c.98N>C | p.Val33Ala | p.V33A | Q9ULC0 | protein_coding | tolerated(0.98) | benign(0.026) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
EMCN | SNV | Missense_Mutation | novel | c.184A>G | p.Lys62Glu | p.K62E | Q9ULC0 | protein_coding | tolerated(0.31) | benign(0.022) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
EMCN | SNV | Missense_Mutation | c.20N>T | p.Thr7Ile | p.T7I | Q9ULC0 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EMCN | SNV | Missense_Mutation | c.235A>G | p.Thr79Ala | p.T79A | Q9ULC0 | protein_coding | tolerated(0.79) | benign(0) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
EMCN | SNV | Missense_Mutation | c.687N>A | p.Asp229Glu | p.D229E | Q9ULC0 | protein_coding | tolerated(0.09) | possibly_damaging(0.606) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
EMCN | SNV | Missense_Mutation | c.216N>T | p.Met72Ile | p.M72I | Q9ULC0 | protein_coding | deleterious(0.02) | benign(0.018) | TCGA-D5-6534-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EMCN | SNV | Missense_Mutation | rs199976013 | c.77N>T | p.Ala26Val | p.A26V | Q9ULC0 | protein_coding | tolerated(0.3) | benign(0.026) | TCGA-F5-6812-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EMCN | deletion | Frame_Shift_Del | c.533delN | p.Asn178MetfsTer22 | p.N178Mfs*22 | Q9ULC0 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
EMCN | SNV | Missense_Mutation | c.496T>C | p.Ser166Pro | p.S166P | Q9ULC0 | protein_coding | tolerated(0.06) | possibly_damaging(0.898) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EMCN | SNV | Missense_Mutation | novel | c.467C>T | p.Ser156Leu | p.S156L | Q9ULC0 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |