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Gene: ELMSAN1 |
Gene summary for ELMSAN1 |
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Gene information | Species | Human | Gene symbol | ELMSAN1 | Gene ID | 91748 |
Gene name | mitotic deacetylase associated SANT domain protein | |
Gene Alias | C14orf117 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R689 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91748 | ELMSAN1 | LZE4T | Human | Esophagus | ESCC | 2.77e-09 | 3.33e-01 | 0.0811 |
91748 | ELMSAN1 | LZE7T | Human | Esophagus | ESCC | 5.13e-03 | 1.16e-01 | 0.0667 |
91748 | ELMSAN1 | LZE8T | Human | Esophagus | ESCC | 2.14e-03 | 4.02e-02 | 0.067 |
91748 | ELMSAN1 | LZE20T | Human | Esophagus | ESCC | 4.38e-02 | 2.06e-01 | 0.0662 |
91748 | ELMSAN1 | LZE24T | Human | Esophagus | ESCC | 2.76e-09 | 2.99e-01 | 0.0596 |
91748 | ELMSAN1 | LZE21T | Human | Esophagus | ESCC | 1.40e-02 | 2.50e-01 | 0.0655 |
91748 | ELMSAN1 | P1T-E | Human | Esophagus | ESCC | 3.93e-05 | 3.48e-01 | 0.0875 |
91748 | ELMSAN1 | P2T-E | Human | Esophagus | ESCC | 1.16e-16 | 4.26e-01 | 0.1177 |
91748 | ELMSAN1 | P4T-E | Human | Esophagus | ESCC | 1.03e-14 | 3.27e-01 | 0.1323 |
91748 | ELMSAN1 | P5T-E | Human | Esophagus | ESCC | 1.19e-17 | 1.58e-01 | 0.1327 |
91748 | ELMSAN1 | P8T-E | Human | Esophagus | ESCC | 4.16e-17 | 3.52e-01 | 0.0889 |
91748 | ELMSAN1 | P9T-E | Human | Esophagus | ESCC | 8.53e-08 | 1.37e-01 | 0.1131 |
91748 | ELMSAN1 | P10T-E | Human | Esophagus | ESCC | 3.56e-33 | 6.10e-01 | 0.116 |
91748 | ELMSAN1 | P11T-E | Human | Esophagus | ESCC | 1.62e-15 | 7.59e-01 | 0.1426 |
91748 | ELMSAN1 | P12T-E | Human | Esophagus | ESCC | 1.19e-13 | 2.61e-01 | 0.1122 |
91748 | ELMSAN1 | P15T-E | Human | Esophagus | ESCC | 5.57e-25 | 5.71e-01 | 0.1149 |
91748 | ELMSAN1 | P16T-E | Human | Esophagus | ESCC | 3.02e-11 | 1.74e-01 | 0.1153 |
91748 | ELMSAN1 | P17T-E | Human | Esophagus | ESCC | 1.54e-07 | 2.86e-01 | 0.1278 |
91748 | ELMSAN1 | P19T-E | Human | Esophagus | ESCC | 1.59e-04 | 4.82e-01 | 0.1662 |
91748 | ELMSAN1 | P20T-E | Human | Esophagus | ESCC | 7.33e-17 | 3.48e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELMSAN1 | SNV | Missense_Mutation | novel | c.1519N>A | p.Ser507Thr | p.S507T | Q6PJG2 | protein_coding | tolerated(0.06) | benign(0.152) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
ELMSAN1 | SNV | Missense_Mutation | novel | c.1668N>T | p.Gln556His | p.Q556H | Q6PJG2 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | insertion | Frame_Shift_Ins | novel | c.1520_1521insAGGTG | p.Glu508GlyfsTer6 | p.E508Gfs*6 | Q6PJG2 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
ELMSAN1 | deletion | Frame_Shift_Del | rs762448666 | c.939delN | p.Asn314ThrfsTer4 | p.N314Tfs*4 | Q6PJG2 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ELMSAN1 | deletion | In_Frame_Del | c.1016_1033delNNNNNNNNNNNNNNNNNN | p.Gln339_Arg344del | p.Q339_R344del | Q6PJG2 | protein_coding | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
ELMSAN1 | SNV | Missense_Mutation | rs141337993 | c.1789N>A | p.Val597Met | p.V597M | Q6PJG2 | protein_coding | tolerated(0.09) | benign(0.006) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ELMSAN1 | SNV | Missense_Mutation | novel | c.2610N>G | p.Phe870Leu | p.F870L | Q6PJG2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
ELMSAN1 | SNV | Missense_Mutation | c.1753N>C | p.Glu585Gln | p.E585Q | Q6PJG2 | protein_coding | deleterious(0.04) | benign(0.063) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ELMSAN1 | SNV | Missense_Mutation | novel | c.1867N>C | p.Val623Leu | p.V623L | Q6PJG2 | protein_coding | tolerated(0.16) | benign(0.112) | TCGA-MU-A8JM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | novel | c.2502N>C | p.Lys834Asn | p.K834N | Q6PJG2 | protein_coding | deleterious(0.02) | benign(0.236) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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