![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ELMOD1 |
Gene summary for ELMOD1 |
![]() |
Gene information | Species | Human | Gene symbol | ELMOD1 | Gene ID | 55531 |
Gene name | ELMO domain containing 1 | |
Gene Alias | ELMOD1 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8N336 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55531 | ELMOD1 | HCC1 | Human | Liver | HCC | 1.68e-11 | 1.34e+00 | 0.5336 |
55531 | ELMOD1 | HCC2 | Human | Liver | HCC | 8.55e-17 | 1.18e+00 | 0.5341 |
55531 | ELMOD1 | HCC5 | Human | Liver | HCC | 5.44e-16 | 1.10e+00 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELMOD1 | SNV | Missense_Mutation | novel | c.304N>T | p.Leu102Phe | p.L102F | Q8N336 | protein_coding | tolerated(0.26) | benign(0.082) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ELMOD1 | SNV | Missense_Mutation | c.529N>C | p.Gly177Arg | p.G177R | Q8N336 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1ET-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ELMOD1 | SNV | Missense_Mutation | rs146878340 | c.867N>G | p.Ile289Met | p.I289M | Q8N336 | protein_coding | tolerated(0.08) | benign(0.069) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ELMOD1 | SNV | Missense_Mutation | rs760709555 | c.253N>G | p.Met85Val | p.M85V | Q8N336 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
ELMOD1 | SNV | Missense_Mutation | c.389N>G | p.Asp130Gly | p.D130G | Q8N336 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ELMOD1 | SNV | Missense_Mutation | rs201382091 | c.64C>T | p.Arg22Cys | p.R22C | Q8N336 | protein_coding | tolerated(0.18) | benign(0.072) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ELMOD1 | SNV | Missense_Mutation | c.178G>A | p.Asp60Asn | p.D60N | Q8N336 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ELMOD1 | SNV | Missense_Mutation | rs201382091 | c.64N>T | p.Arg22Cys | p.R22C | Q8N336 | protein_coding | tolerated(0.18) | benign(0.072) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
ELMOD1 | SNV | Missense_Mutation | c.206N>A | p.Ser69Tyr | p.S69Y | Q8N336 | protein_coding | deleterious(0.02) | benign(0.285) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ELMOD1 | SNV | Missense_Mutation | novel | c.52A>G | p.Lys18Glu | p.K18E | Q8N336 | protein_coding | tolerated(0.46) | benign(0.028) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |