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Gene: ELAPOR1 |
Gene summary for ELAPOR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ELAPOR1 | Gene ID | 57535 |
| Gene name | endosome-lysosome associated apoptosis and autophagy regulator 1 | |
| Gene Alias | EIG121 | |
| Cytomap | 1p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q6UXG2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57535 | ELAPOR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.01e-80 | 1.30e+00 | 0.0155 |
| 57535 | ELAPOR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.83e-24 | 8.57e-01 | -0.1808 |
| 57535 | ELAPOR1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.22e-30 | 1.80e+00 | 0.0216 |
| 57535 | ELAPOR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.04e-15 | 7.08e-01 | -0.0811 |
| 57535 | ELAPOR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.35e-37 | 1.15e+00 | -0.1088 |
| 57535 | ELAPOR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.34e-48 | 1.38e+00 | -0.1954 |
| 57535 | ELAPOR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 1.57e+00 | -0.2602 |
| 57535 | ELAPOR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.26e-10 | 8.18e-01 | -0.2196 |
| 57535 | ELAPOR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.99e-38 | 1.23e+00 | -0.1207 |
| 57535 | ELAPOR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.95e-16 | 8.86e-01 | -0.1526 |
| 57535 | ELAPOR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.81e-87 | 2.22e+00 | -0.1464 |
| 57535 | ELAPOR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.37e-56 | 1.46e+00 | -0.1001 |
| 57535 | ELAPOR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.37e-44 | 1.75e+00 | -0.059 |
| 57535 | ELAPOR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.27e-18 | 1.03e+00 | -0.1706 |
| 57535 | ELAPOR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.52e-06 | 6.68e-01 | -0.2061 |
| 57535 | ELAPOR1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.21e-18 | 8.56e-01 | -0.1462 |
| 57535 | ELAPOR1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.51e-45 | 1.85e+00 | -0.0842 |
| 57535 | ELAPOR1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 6.89e-14 | 8.27e-01 | -0.00410000000000005 |
| 57535 | ELAPOR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.78e-35 | 1.37e+00 | -0.0179 |
| 57535 | ELAPOR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.50e-102 | 2.00e+00 | 0.096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
| GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
| GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
| GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
| GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
| GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
| GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
| GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
| GO:0010508 | Colorectum | AD | positive regulation of autophagy | 43/3918 | 124/18723 | 2.64e-04 | 3.27e-03 | 43 |
| GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
| GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
| GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
| GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
| GO:00098961 | Colorectum | SER | positive regulation of catabolic process | 132/2897 | 492/18723 | 4.16e-11 | 6.72e-09 | 132 |
| GO:00313311 | Colorectum | SER | positive regulation of cellular catabolic process | 114/2897 | 427/18723 | 1.22e-09 | 1.27e-07 | 114 |
| GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
| GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
| GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
| GO:00425941 | Colorectum | SER | response to starvation | 47/2897 | 197/18723 | 1.31e-03 | 1.45e-02 | 47 |
| GO:00714961 | Colorectum | SER | cellular response to external stimulus | 70/2897 | 320/18723 | 1.40e-03 | 1.53e-02 | 70 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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