GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
GO:0002183 | Colorectum | AD | cytoplasmic translational initiation | 21/3918 | 34/18723 | 2.73e-07 | 1.09e-05 | 21 |
GO:0001732 | Colorectum | AD | formation of cytoplasmic translation initiation complex | 13/3918 | 16/18723 | 4.27e-07 | 1.64e-05 | 13 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0034250 | Colorectum | AD | positive regulation of cellular amide metabolic process | 53/3918 | 162/18723 | 2.98e-04 | 3.60e-03 | 53 |
GO:0045727 | Colorectum | AD | positive regulation of translation | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
GO:00021831 | Colorectum | SER | cytoplasmic translational initiation | 18/2897 | 34/18723 | 4.42e-07 | 2.24e-05 | 18 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00017321 | Colorectum | SER | formation of cytoplasmic translation initiation complex | 10/2897 | 16/18723 | 2.52e-05 | 6.96e-04 | 10 |
GO:00064131 | Colorectum | SER | translational initiation | 36/2897 | 118/18723 | 2.84e-05 | 7.63e-04 | 36 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF3C | SNV | Missense_Mutation | | c.964N>T | p.Thr322Ser | p.T322S | Q99613 | protein_coding | tolerated(0.17) | probably_damaging(0.989) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | | c.801N>C | p.Lys267Asn | p.K267N | Q99613 | protein_coding | tolerated(0.18) | benign(0.399) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | | c.832G>A | p.Ala278Thr | p.A278T | Q99613 | protein_coding | tolerated(0.45) | benign(0.029) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | novel | c.1015G>A | p.Ala339Thr | p.A339T | Q99613 | protein_coding | deleterious(0.04) | probably_damaging(0.949) | TCGA-AP-A0LN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | novel | c.784A>G | p.Thr262Ala | p.T262A | Q99613 | protein_coding | tolerated(0.73) | benign(0) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | novel | c.778N>A | p.Ala260Thr | p.A260T | Q99613 | protein_coding | tolerated(0.57) | benign(0.009) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
EIF3C | SNV | Missense_Mutation | rs766394588 | c.811N>A | p.Glu271Lys | p.E271K | Q99613 | protein_coding | tolerated(0.88) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
EIF3C | SNV | Missense_Mutation | novel | c.1039N>A | p.Arg347Ser | p.R347S | Q99613 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
EIF3C | SNV | Missense_Mutation | rs767062124 | c.993G>T | p.Lys331Asn | p.K331N | Q99613 | protein_coding | tolerated(0.15) | probably_damaging(0.997) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3C | SNV | Missense_Mutation | rs757977079 | c.913N>T | p.Arg305Trp | p.R305W | Q99613 | protein_coding | deleterious(0) | benign(0.381) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |