|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: EIF1AY |
Gene summary for EIF1AY |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | EIF1AY | Gene ID | 9086 |
| Gene name | eukaryotic translation initiation factor 1A Y-linked | |
| Gene Alias | eIF-4C | |
| Cytomap | Yq11.223 | |
| Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A6NJH9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9086 | EIF1AY | LZE2T | Human | Esophagus | ESCC | 3.86e-04 | 3.29e-01 | 0.082 |
| 9086 | EIF1AY | LZE4T | Human | Esophagus | ESCC | 2.74e-11 | 2.72e-01 | 0.0811 |
| 9086 | EIF1AY | LZE7T | Human | Esophagus | ESCC | 1.42e-02 | -2.71e-02 | 0.0667 |
| 9086 | EIF1AY | LZE24T | Human | Esophagus | ESCC | 3.72e-02 | -1.39e-01 | 0.0596 |
| 9086 | EIF1AY | P1T-E | Human | Esophagus | ESCC | 9.32e-07 | 3.25e-01 | 0.0875 |
| 9086 | EIF1AY | P5T-E | Human | Esophagus | ESCC | 1.68e-19 | 4.01e-01 | 0.1327 |
| 9086 | EIF1AY | P9T-E | Human | Esophagus | ESCC | 4.70e-04 | -1.12e-01 | 0.1131 |
| 9086 | EIF1AY | P10T-E | Human | Esophagus | ESCC | 2.05e-20 | 4.42e-01 | 0.116 |
| 9086 | EIF1AY | P12T-E | Human | Esophagus | ESCC | 5.83e-25 | 3.95e-01 | 0.1122 |
| 9086 | EIF1AY | P20T-E | Human | Esophagus | ESCC | 6.25e-17 | 1.39e-01 | 0.1124 |
| 9086 | EIF1AY | P22T-E | Human | Esophagus | ESCC | 1.99e-42 | 6.01e-01 | 0.1236 |
| 9086 | EIF1AY | P23T-E | Human | Esophagus | ESCC | 4.24e-14 | 3.41e-01 | 0.108 |
| 9086 | EIF1AY | P24T-E | Human | Esophagus | ESCC | 3.71e-05 | -3.27e-03 | 0.1287 |
| 9086 | EIF1AY | P26T-E | Human | Esophagus | ESCC | 1.62e-16 | 3.65e-01 | 0.1276 |
| 9086 | EIF1AY | P27T-E | Human | Esophagus | ESCC | 3.53e-04 | -5.75e-02 | 0.1055 |
| 9086 | EIF1AY | P28T-E | Human | Esophagus | ESCC | 1.41e-19 | 3.50e-01 | 0.1149 |
| 9086 | EIF1AY | P37T-E | Human | Esophagus | ESCC | 1.86e-15 | 2.56e-01 | 0.1371 |
| 9086 | EIF1AY | P42T-E | Human | Esophagus | ESCC | 4.14e-05 | 2.49e-02 | 0.1175 |
| 9086 | EIF1AY | P44T-E | Human | Esophagus | ESCC | 2.07e-07 | 1.88e-01 | 0.1096 |
| 9086 | EIF1AY | P52T-E | Human | Esophagus | ESCC | 4.43e-41 | 9.15e-01 | 0.1555 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
| GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
| GO:000641322 | Liver | HCC | translational initiation | 94/7958 | 118/18723 | 1.39e-16 | 1.24e-14 | 94 |
| GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
| GO:000641325 | Oral cavity | EOLP | translational initiation | 37/2218 | 118/18723 | 1.39e-08 | 6.43e-07 | 37 |
| GO:000641333 | Oral cavity | NEOLP | translational initiation | 39/2005 | 118/18723 | 5.20e-11 | 6.30e-09 | 39 |
| GO:000641316 | Prostate | BPH | translational initiation | 59/3107 | 118/18723 | 4.78e-17 | 1.14e-14 | 59 |
| GO:000641317 | Prostate | Tumor | translational initiation | 66/3246 | 118/18723 | 2.57e-21 | 2.66e-18 | 66 |
| GO:0006413111 | Skin | cSCC | translational initiation | 84/4864 | 118/18723 | 9.12e-25 | 2.29e-22 | 84 |
| GO:0006413112 | Thyroid | PTC | translational initiation | 84/5968 | 118/18723 | 1.89e-18 | 2.09e-16 | 84 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| EIF1AY | SNV | Missense_Mutation | c.37C>T | p.Arg13Cys | p.R13C | O14602 | protein_coding | deleterious(0.04) | possibly_damaging(0.667) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |