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Gene: EFS |
Gene summary for EFS |
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Gene information | Species | Human | Gene symbol | EFS | Gene ID | 10278 |
Gene name | embryonal Fyn-associated substrate | |
Gene Alias | CAS3 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | O43281 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10278 | EFS | LZE7T | Human | Esophagus | ESCC | 2.20e-04 | 1.80e-01 | 0.0667 |
10278 | EFS | LZE24T | Human | Esophagus | ESCC | 4.01e-08 | 1.47e-01 | 0.0596 |
10278 | EFS | P1T-E | Human | Esophagus | ESCC | 1.01e-05 | 2.08e-01 | 0.0875 |
10278 | EFS | P2T-E | Human | Esophagus | ESCC | 3.59e-11 | 1.91e-01 | 0.1177 |
10278 | EFS | P4T-E | Human | Esophagus | ESCC | 1.09e-08 | 1.90e-01 | 0.1323 |
10278 | EFS | P5T-E | Human | Esophagus | ESCC | 3.07e-05 | 2.88e-02 | 0.1327 |
10278 | EFS | P8T-E | Human | Esophagus | ESCC | 6.90e-19 | 2.54e-01 | 0.0889 |
10278 | EFS | P9T-E | Human | Esophagus | ESCC | 5.75e-10 | 1.76e-01 | 0.1131 |
10278 | EFS | P10T-E | Human | Esophagus | ESCC | 1.23e-14 | 2.31e-01 | 0.116 |
10278 | EFS | P11T-E | Human | Esophagus | ESCC | 2.11e-06 | 3.89e-01 | 0.1426 |
10278 | EFS | P12T-E | Human | Esophagus | ESCC | 1.16e-18 | 3.79e-01 | 0.1122 |
10278 | EFS | P15T-E | Human | Esophagus | ESCC | 6.39e-15 | 3.30e-01 | 0.1149 |
10278 | EFS | P16T-E | Human | Esophagus | ESCC | 1.03e-14 | 2.19e-01 | 0.1153 |
10278 | EFS | P17T-E | Human | Esophagus | ESCC | 8.60e-06 | 2.78e-01 | 0.1278 |
10278 | EFS | P20T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.26e-01 | 0.1124 |
10278 | EFS | P21T-E | Human | Esophagus | ESCC | 1.91e-05 | 8.75e-02 | 0.1617 |
10278 | EFS | P22T-E | Human | Esophagus | ESCC | 8.78e-12 | 1.30e-01 | 0.1236 |
10278 | EFS | P23T-E | Human | Esophagus | ESCC | 3.55e-11 | 1.63e-01 | 0.108 |
10278 | EFS | P24T-E | Human | Esophagus | ESCC | 1.25e-07 | 1.01e-01 | 0.1287 |
10278 | EFS | P26T-E | Human | Esophagus | ESCC | 1.29e-04 | 1.00e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:003153218 | Esophagus | ESCC | actin cytoskeleton reorganization | 72/8552 | 107/18723 | 5.03e-06 | 5.31e-05 | 72 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00064177 | Liver | NAFLD | regulation of translation | 85/1882 | 468/18723 | 4.58e-08 | 4.54e-06 | 85 |
GO:00064145 | Liver | NAFLD | translational elongation | 16/1882 | 55/18723 | 6.71e-05 | 1.44e-03 | 16 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
GO:0006417110 | Oral cavity | LP | regulation of translation | 175/4623 | 468/18723 | 4.49e-10 | 2.22e-08 | 175 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFS | SNV | Missense_Mutation | c.1033C>A | p.Pro345Thr | p.P345T | O43281 | protein_coding | deleterious(0.01) | benign(0.062) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
EFS | SNV | Missense_Mutation | c.1624G>T | p.Val542Leu | p.V542L | O43281 | protein_coding | deleterious(0.04) | possibly_damaging(0.894) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
EFS | SNV | Missense_Mutation | novel | c.964N>T | p.Pro322Ser | p.P322S | O43281 | protein_coding | tolerated(0.2) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | rs533627167 | c.911N>A | p.Arg304His | p.R304H | O43281 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | c.1644N>T | p.Gln548His | p.Q548H | O43281 | protein_coding | tolerated(0.26) | benign(0.023) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EFS | SNV | Missense_Mutation | c.568N>A | p.Val190Met | p.V190M | O43281 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
EFS | SNV | Missense_Mutation | novel | c.356C>A | p.Pro119His | p.P119H | O43281 | protein_coding | deleterious(0.03) | benign(0.436) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | novel | c.281N>T | p.Ser94Ile | p.S94I | O43281 | protein_coding | deleterious(0.05) | benign(0.259) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
EFS | SNV | Missense_Mutation | rs774043832 | c.677C>T | p.Ala226Val | p.A226V | O43281 | protein_coding | tolerated(0.26) | benign(0.095) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EFS | SNV | Missense_Mutation | rs780112461 | c.311N>T | p.Pro104Leu | p.P104L | O43281 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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