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Gene: EFCAB10 |
Gene summary for EFCAB10 |
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Gene information | Species | Human | Gene symbol | EFCAB10 | Gene ID | 100130771 |
Gene name | EF-hand calcium binding domain 10 | |
Gene Alias | EFCAB10 | |
Cytomap | 7q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100130771 | EFCAB10 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.55e-02 | 1.48e-01 | -0.1088 |
100130771 | EFCAB10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.19e-09 | 2.15e-01 | -0.1954 |
100130771 | EFCAB10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.57e-04 | 1.43e-01 | -0.059 |
100130771 | EFCAB10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.12e-03 | 2.60e-01 | -0.1462 |
100130771 | EFCAB10 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.78e-24 | 6.91e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFCAB10 | SNV | Missense_Mutation | novel | c.154N>C | p.Ala52Pro | p.A52P | A6NFE3 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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