Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: EEF1AKMT4

Gene summary for EEF1AKMT4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

EEF1AKMT4

Gene ID

110599564

Gene nameEEF1A lysine methyltransferase 4
Gene AliasEEF1AKMT4
Cytomap3q27.1
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

NA


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
110599564EEF1AKMT4LZE2THumanEsophagusESCC4.73e-036.08e-010.082
110599564EEF1AKMT4LZE4THumanEsophagusESCC6.68e-226.08e-010.0811
110599564EEF1AKMT4LZE5THumanEsophagusESCC1.48e-053.63e-010.0514
110599564EEF1AKMT4LZE7THumanEsophagusESCC2.56e-052.67e-010.0667
110599564EEF1AKMT4LZE8THumanEsophagusESCC2.72e-032.12e-010.067
110599564EEF1AKMT4LZE20THumanEsophagusESCC4.88e-051.97e-010.0662
110599564EEF1AKMT4LZE21D1HumanEsophagusHGIN5.38e-033.63e-010.0632
110599564EEF1AKMT4LZE22THumanEsophagusESCC1.40e-065.38e-010.068
110599564EEF1AKMT4LZE24THumanEsophagusESCC8.01e-194.62e-010.0596
110599564EEF1AKMT4LZE21THumanEsophagusESCC1.37e-063.87e-010.0655
110599564EEF1AKMT4LZE6THumanEsophagusESCC3.01e-064.38e-010.0845
110599564EEF1AKMT4ATC12HumanThyroidATC5.14e-039.59e-020.34
110599564EEF1AKMT4ATC2HumanThyroidATC1.60e-075.38e-010.34
110599564EEF1AKMT4ATC4HumanThyroidATC1.97e-051.60e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00182057EsophagusHGINpeptidyl-lysine modification88/2587376/187232.99e-071.39e-0588
GO:00064798EsophagusHGINprotein methylation38/2587181/187235.05e-034.22e-0238
GO:00082138EsophagusHGINprotein alkylation38/2587181/187235.05e-034.22e-0238
GO:00180227EsophagusHGINpeptidyl-lysine methylation29/2587131/187236.22e-034.95e-0229
GO:001820514EsophagusESCCpeptidyl-lysine modification259/8552376/187233.90e-205.26e-18259
GO:00434143EsophagusESCCmacromolecule methylation199/8552316/187233.44e-109.57e-09199
GO:00322592EsophagusESCCmethylation222/8552364/187232.26e-095.09e-08222
GO:000647914EsophagusESCCprotein methylation115/8552181/187239.07e-071.16e-05115
GO:000821314EsophagusESCCprotein alkylation115/8552181/187239.07e-071.16e-05115
GO:001802214EsophagusESCCpeptidyl-lysine methylation79/8552131/187235.17e-042.86e-0379
GO:001820516ThyroidATCpeptidyl-lysine modification193/6293376/187236.92e-133.06e-11193
GO:000647916ThyroidATCprotein methylation85/6293181/187231.27e-049.00e-0485
GO:000821316ThyroidATCprotein alkylation85/6293181/187231.27e-049.00e-0485
GO:004341412ThyroidATCmacromolecule methylation131/6293316/187232.01e-039.60e-03131
GO:003225911ThyroidATCmethylation148/6293364/187232.69e-031.23e-02148
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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