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Gene: ECM2 |
Gene summary for ECM2 |
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Gene information | Species | Human | Gene symbol | ECM2 | Gene ID | 1842 |
Gene name | extracellular matrix protein 2 | |
Gene Alias | ECM2 | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | O94769 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1842 | ECM2 | ATC13 | Human | Thyroid | ATC | 5.98e-37 | 7.20e-01 | 0.34 |
1842 | ECM2 | ATC5 | Human | Thyroid | ATC | 3.00e-45 | 7.60e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:001081029 | Thyroid | ATC | regulation of cell-substrate adhesion | 128/6293 | 221/18723 | 8.74e-14 | 4.57e-12 | 128 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:0010811210 | Thyroid | ATC | positive regulation of cell-substrate adhesion | 73/6293 | 123/18723 | 4.12e-09 | 9.37e-08 | 73 |
GO:0045785210 | Thyroid | ATC | positive regulation of cell adhesion | 194/6293 | 437/18723 | 1.40e-06 | 1.75e-05 | 194 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ECM2 | SNV | Missense_Mutation | c.661G>C | p.Glu221Gln | p.E221Q | O94769 | protein_coding | tolerated(0.28) | benign(0.06) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | |
ECM2 | SNV | Missense_Mutation | rs778924845 | c.797N>A | p.Arg266His | p.R266H | O94769 | protein_coding | tolerated(0.3) | benign(0) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ECM2 | SNV | Missense_Mutation | c.638N>T | p.Ser213Phe | p.S213F | O94769 | protein_coding | tolerated(0.79) | benign(0) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ECM2 | deletion | Frame_Shift_Del | novel | c.2051delN | p.Cys684SerfsTer2 | p.C684Sfs*2 | O94769 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ECM2 | SNV | Missense_Mutation | rs183564221 | c.2074N>A | p.Val692Ile | p.V692I | O94769 | protein_coding | tolerated(0.24) | benign(0.204) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ECM2 | SNV | Missense_Mutation | novel | c.1241N>G | p.Ser414Cys | p.S414C | O94769 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ECM2 | SNV | Missense_Mutation | c.1865C>G | p.Ser622Cys | p.S622C | O94769 | protein_coding | tolerated(0.11) | benign(0.076) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ECM2 | SNV | Missense_Mutation | novel | c.1067N>A | p.Ala356Asp | p.A356D | O94769 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ECM2 | SNV | Missense_Mutation | c.1897C>A | p.Leu633Ile | p.L633I | O94769 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ECM2 | SNV | Missense_Mutation | rs775294587 | c.994N>A | p.Ala332Thr | p.A332T | O94769 | protein_coding | tolerated(0.12) | benign(0.022) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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