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Gene: EBP |
Gene summary for EBP |
Gene summary. |
Gene information | Species | Human | Gene symbol | EBP | Gene ID | 10682 |
Gene name | EBP cholestenol delta-isomerase | |
Gene Alias | CDPX2 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A024QYX0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10682 | EBP | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.97e-13 | 5.22e-01 | -0.1808 |
10682 | EBP | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.67e-11 | 4.66e-01 | -0.0811 |
10682 | EBP | HTA11_78_2000001011 | Human | Colorectum | AD | 3.18e-03 | 1.92e-01 | -0.1088 |
10682 | EBP | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-25 | 5.81e-01 | -0.1954 |
10682 | EBP | HTA11_411_2000001011 | Human | Colorectum | SER | 1.70e-05 | 9.17e-01 | -0.2602 |
10682 | EBP | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.07e-10 | 1.43e+00 | -0.2196 |
10682 | EBP | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.44e-07 | 3.69e-01 | -0.1207 |
10682 | EBP | HTA11_83_2000001011 | Human | Colorectum | SER | 5.94e-10 | 5.41e-01 | -0.1526 |
10682 | EBP | HTA11_696_2000001011 | Human | Colorectum | AD | 6.62e-24 | 6.23e-01 | -0.1464 |
10682 | EBP | HTA11_866_2000001011 | Human | Colorectum | AD | 2.90e-06 | 2.42e-01 | -0.1001 |
10682 | EBP | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.23e-12 | 4.72e-01 | -0.059 |
10682 | EBP | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.60e-05 | 4.20e-01 | -0.1706 |
10682 | EBP | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.57e-02 | 4.09e-01 | -0.1462 |
10682 | EBP | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.36e-04 | 2.83e-01 | -0.0179 |
10682 | EBP | HTA11_866_3004761011 | Human | Colorectum | AD | 2.32e-06 | 2.85e-01 | 0.096 |
10682 | EBP | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.42e-02 | 4.09e-01 | 0.0446 |
10682 | EBP | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.01e-04 | 4.79e-01 | 0.0131 |
10682 | EBP | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.14e-07 | 6.09e-01 | 0.0171 |
10682 | EBP | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.65e-03 | 2.40e-01 | 0.0338 |
10682 | EBP | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.54e-07 | 2.99e-01 | 0.0674 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00064138 | Breast | Precancer | translational initiation | 30/1080 | 118/18723 | 3.23e-12 | 5.58e-10 | 30 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00362948 | Breast | Precancer | cellular response to decreased oxygen levels | 31/1080 | 161/18723 | 2.61e-09 | 2.11e-07 | 31 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00714538 | Breast | Precancer | cellular response to oxygen levels | 32/1080 | 177/18723 | 7.32e-09 | 5.52e-07 | 32 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00714565 | Breast | Precancer | cellular response to hypoxia | 29/1080 | 151/18723 | 8.98e-09 | 6.50e-07 | 29 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00064466 | Breast | Precancer | regulation of translational initiation | 19/1080 | 79/18723 | 7.99e-08 | 4.60e-06 | 19 |
GO:00518816 | Breast | Precancer | regulation of mitochondrial membrane potential | 18/1080 | 74/18723 | 1.45e-07 | 7.82e-06 | 18 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa001005 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa0010012 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa00100 | Liver | Cirrhotic | Steroid biosynthesis | 12/2530 | 20/8465 | 4.92e-03 | 1.76e-02 | 1.09e-02 | 12 |
hsa001001 | Liver | Cirrhotic | Steroid biosynthesis | 12/2530 | 20/8465 | 4.92e-03 | 1.76e-02 | 1.09e-02 | 12 |
hsa001002 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001003 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001004 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010011 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010021 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
hsa0010031 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EBP | SNV | Missense_Mutation | rs782423797 | c.208N>T | p.Ala70Ser | p.A70S | Q15125 | protein_coding | tolerated(0.07) | possibly_damaging(0.489) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1X7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-E9-A1NG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
EBP | deletion | Frame_Shift_Del | novel | c.170delC | p.Pro57HisfsTer22 | p.P57Hfs*22 | Q15125 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EBP | SNV | Missense_Mutation | rs28935174 | c.440N>A | p.Arg147His | p.R147H | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10682 | EBP | DRUGGABLE GENOME, ENZYME | SR-31747 |
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