Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DZIP1

Gene summary for DZIP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DZIP1

Gene ID

22873

Gene nameDAZ interacting zinc finger protein 1
Gene AliasDZIP
Cytomap13q32.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q86YF9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
22873DZIP1male-WTAHumanThyroidPTC2.43e-036.83e-020.1037
22873DZIP1PTC06HumanThyroidPTC1.21e-021.14e-010.2057
22873DZIP1ATC11HumanThyroidATC7.49e-032.53e-010.3386
22873DZIP1ATC13HumanThyroidATC2.86e-335.60e-010.34
22873DZIP1ATC4HumanThyroidATC2.74e-031.08e-010.34
22873DZIP1ATC5HumanThyroidATC1.46e-366.15e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00219159EsophagusESCCneural tube development101/8552152/187231.78e-072.79e-06101
GO:0051098113ThyroidPTCregulation of binding195/5968363/187233.21e-183.37e-16195
GO:0045185113ThyroidPTCmaintenance of protein location64/596894/187235.92e-132.85e-1164
GO:0031346110ThyroidPTCpositive regulation of cell projection organization173/5968353/187231.09e-114.40e-10173
GO:0043393111ThyroidPTCregulation of protein binding103/5968196/187231.39e-093.96e-08103
GO:0051235112ThyroidPTCmaintenance of location148/5968327/187232.30e-074.07e-06148
GO:0120032111ThyroidPTCregulation of plasma membrane bounded cell projection assembly92/5968186/187234.12e-076.83e-0692
GO:006049120ThyroidPTCregulation of cell projection assembly92/5968188/187237.55e-071.18e-0592
GO:01200349ThyroidPTCpositive regulation of plasma membrane bounded cell projection assembly57/5968105/187231.60e-062.25e-0557
GO:190211516ThyroidPTCregulation of organelle assembly88/5968186/187237.41e-068.65e-0588
GO:19021176ThyroidPTCpositive regulation of organelle assembly35/596867/187234.24e-042.83e-0335
GO:00512207ThyroidPTCcytoplasmic sequestering of protein15/596822/187235.11e-043.32e-0315
GO:005109834ThyroidATCregulation of binding203/6293363/187231.18e-181.55e-16203
GO:003134623ThyroidATCpositive regulation of cell projection organization186/6293353/187237.99e-144.23e-12186
GO:004518532ThyroidATCmaintenance of protein location64/629394/187238.44e-123.16e-1064
GO:004339327ThyroidATCregulation of protein binding110/6293196/187236.99e-112.22e-09110
GO:012003414ThyroidATCpositive regulation of plasma membrane bounded cell projection assembly60/6293105/187236.10e-078.47e-0660
GO:012003223ThyroidATCregulation of plasma membrane bounded cell projection assembly95/6293186/187236.13e-078.49e-0695
GO:005123532ThyroidATCmaintenance of location152/6293327/187237.84e-071.04e-05152
GO:0060491111ThyroidATCregulation of cell projection assembly95/6293188/187231.14e-061.47e-0595
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DZIP1SNVMissense_Mutationrs138320927c.954N>Tp.Lys318Asnp.K318NQ86YF9protein_codingdeleterious(0)probably_damaging(0.922)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DZIP1SNVMissense_Mutationrs147653120c.2494N>Ap.Ala832Thrp.A832TQ86YF9protein_codingtolerated(0.32)benign(0.003)TCGA-GM-A3NW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
DZIP1insertionFrame_Shift_Insnovelc.2091_2092insTTGGAAAACTCTCTGGAAACTGTATTTAGGACAGTTGTCCTCAp.Pro698LeufsTer37p.P698Lfs*37Q86YF9protein_codingTCGA-A2-A0EQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
DZIP1SNVMissense_Mutationc.1033N>Cp.Asp345Hisp.D345HQ86YF9protein_codingdeleterious(0)probably_damaging(0.999)TCGA-C5-A1BJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
DZIP1SNVMissense_Mutationnovelc.344N>Tp.Pro115Leup.P115LQ86YF9protein_codingdeleterious(0)probably_damaging(1)TCGA-C5-A1ME-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
DZIP1SNVMissense_Mutationc.2578G>Ap.Asp860Asnp.D860NQ86YF9protein_codingdeleterious(0)possibly_damaging(0.817)TCGA-EK-A2PG-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
DZIP1SNVMissense_Mutationc.406G>Cp.Glu136Glnp.E136QQ86YF9protein_codingdeleterious(0)probably_damaging(0.993)TCGA-IR-A3LI-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DZIP1SNVMissense_Mutationrs770171062c.2053N>Ap.Glu685Lysp.E685KQ86YF9protein_codingdeleterious(0)possibly_damaging(0.498)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
DZIP1SNVMissense_Mutationnovelc.1394N>Gp.Ser465Cysp.S465CQ86YF9protein_codingdeleterious(0.02)benign(0.111)TCGA-MA-AA3Y-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
DZIP1deletionFrame_Shift_Delnovelc.2027delNp.Thr676ArgfsTer42p.T676Rfs*42Q86YF9protein_codingTCGA-LP-A7HU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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