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Gene: DUXA |
Gene summary for DUXA |
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Gene information | Species | Human | Gene symbol | DUXA | Gene ID | 503835 |
Gene name | double homeobox A | |
Gene Alias | DUXA | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A6NLW8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
503835 | DUXA | HCC1 | Human | Liver | HCC | 3.64e-19 | 1.45e+00 | 0.5336 |
503835 | DUXA | HCC2 | Human | Liver | HCC | 3.58e-20 | 1.22e+00 | 0.5341 |
503835 | DUXA | HCC5 | Human | Liver | HCC | 2.24e-24 | 1.62e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUXA | SNV | Missense_Mutation | c.106N>G | p.Gln36Glu | p.Q36E | A6NLW8 | protein_coding | deleterious(0.02) | possibly_damaging(0.682) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
DUXA | insertion | In_Frame_Ins | novel | c.351_352insTATTTGACTGAAGTCTTTATGTCTACTGTATCCTTCAGATCTTCT | p.Ile117_Lys118insTyrLeuThrGluValPheMetSerThrValSerPheArgSerSer | p.I117_K118insYLTEVFMSTVSFRSS | A6NLW8 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DUXA | SNV | Missense_Mutation | c.594N>A | p.Phe198Leu | p.F198L | A6NLW8 | protein_coding | tolerated_low_confidence(0.2) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DUXA | SNV | Missense_Mutation | rs866701297 | c.529C>T | p.Pro177Ser | p.P177S | A6NLW8 | protein_coding | tolerated_low_confidence(0.65) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUXA | SNV | Missense_Mutation | c.232N>A | p.Ala78Thr | p.A78T | A6NLW8 | protein_coding | tolerated(0.34) | benign(0.018) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DUXA | SNV | Missense_Mutation | c.173G>T | p.Arg58Ile | p.R58I | A6NLW8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
DUXA | SNV | Missense_Mutation | c.451N>C | p.Asn151His | p.N151H | A6NLW8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
DUXA | SNV | Missense_Mutation | rs200454436 | c.211N>A | p.Gly71Arg | p.G71R | A6NLW8 | protein_coding | tolerated(0.55) | benign(0) | TCGA-D5-6924-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUXA | SNV | Missense_Mutation | rs748002224 | c.50G>A | p.Arg17His | p.R17H | A6NLW8 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DUXA | SNV | Missense_Mutation | c.27G>T | p.Lys9Asn | p.K9N | A6NLW8 | protein_coding | deleterious_low_confidence(0.02) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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