Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: DST

Gene summary for DST

Gene summary.

Gene information	Species	Human
	Gene symbol	DST
	Gene ID	667
	Gene name	dystonin
	Gene Alias	BP240
	Cytomap	6p12.1
	Gene Type	protein-coding
	GO ID	GO:0000226
	UniProtAcc	B4DSS9

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
667	DST	GSM4909281	Human	Breast	IDC	2.92e-03	-3.62e-01	0.21
667	DST	GSM4909282	Human	Breast	IDC	3.84e-17	-5.25e-01	-0.0288
667	DST	GSM4909286	Human	Breast	IDC	1.03e-06	-3.84e-01	0.1081
667	DST	GSM4909287	Human	Breast	IDC	1.34e-08	-4.01e-01	0.2057
667	DST	GSM4909290	Human	Breast	IDC	1.17e-08	-4.62e-01	0.2096
667	DST	GSM4909293	Human	Breast	IDC	3.47e-11	-4.92e-01	0.1581
667	DST	GSM4909294	Human	Breast	IDC	2.89e-05	-4.28e-01	0.2022
667	DST	GSM4909296	Human	Breast	IDC	1.18e-17	-5.60e-01	0.1524
667	DST	GSM4909297	Human	Breast	IDC	2.00e-12	-5.14e-01	0.1517
667	DST	GSM4909298	Human	Breast	IDC	1.93e-02	-3.56e-01	0.1551
667	DST	GSM4909301	Human	Breast	IDC	2.86e-05	-4.36e-01	0.1577
667	DST	GSM4909302	Human	Breast	IDC	1.83e-15	-4.79e-01	0.1545
667	DST	GSM4909303	Human	Breast	IDC	7.43e-03	-4.71e-01	0.0438
667	DST	GSM4909304	Human	Breast	IDC	2.01e-22	-6.00e-01	0.1636
667	DST	GSM4909305	Human	Breast	IDC	8.32e-04	-3.64e-01	0.0436
667	DST	GSM4909306	Human	Breast	IDC	5.79e-17	-5.62e-01	0.1564
667	DST	GSM4909307	Human	Breast	IDC	3.63e-03	-3.62e-01	0.1569
667	DST	GSM4909308	Human	Breast	IDC	2.15e-08	-4.20e-01	0.158
667	DST	GSM4909309	Human	Breast	IDC	3.83e-06	-3.24e-01	0.0483
667	DST	GSM4909311	Human	Breast	IDC	5.66e-29	-5.93e-01	0.1534

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Breast		IDC: Invasive ductal carcinoma
		DCIS: Ductal carcinoma in situ
		Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
GC		CAG: Chronic atrophic gastritis
		CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
		CSG: Chronic superficial gastritis
		GC: Gastric cancer
		SIM: Severe intestinal metaplasia
		WIM: Wild intestinal metaplasia
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Prostate		BPH: Benign Prostatic Hyperplasia
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00420609	Breast	Precancer	wound healing	48/1080	422/18723	5.48e-06	1.63e-04	48
GO:19029059	Breast	Precancer	positive regulation of supramolecular fiber organization	28/1080	209/18723	2.79e-05	6.28e-04	28
GO:19029039	Breast	Precancer	regulation of supramolecular fiber organization	42/1080	383/18723	4.92e-05	1.04e-03	42
GO:00329709	Breast	Precancer	regulation of actin filament-based process	42/1080	397/18723	1.11e-04	2.01e-03	42
GO:00514959	Breast	Precancer	positive regulation of cytoskeleton organization	28/1080	226/18723	1.13e-04	2.04e-03	28
GO:0045104	Breast	Precancer	intermediate filament cytoskeleton organization	11/1080	51/18723	1.26e-04	2.22e-03	11
GO:0045103	Breast	Precancer	intermediate filament-based process	11/1080	52/18723	1.52e-04	2.60e-03	11
GO:00070159	Breast	Precancer	actin filament organization	44/1080	442/18723	3.02e-04	4.35e-03	44
GO:00224119	Breast	Precancer	cellular component disassembly	44/1080	443/18723	3.17e-04	4.51e-03	44
GO:00329569	Breast	Precancer	regulation of actin cytoskeleton organization	36/1080	358/18723	8.56e-04	9.88e-03	36
GO:01100539	Breast	Precancer	regulation of actin filament organization	29/1080	278/18723	1.50e-03	1.55e-02	29
GO:00071638	Breast	Precancer	establishment or maintenance of cell polarity	23/1080	218/18723	3.82e-03	3.06e-02	23
GO:01501158	Breast	Precancer	cell-substrate junction organization	13/1080	101/18723	5.30e-03	3.94e-02	13
GO:190290514	Breast	IDC	positive regulation of supramolecular fiber organization	37/1434	209/18723	1.33e-06	5.75e-05	37
GO:003297014	Breast	IDC	regulation of actin filament-based process	56/1434	397/18723	6.37e-06	1.99e-04	56
GO:190290314	Breast	IDC	regulation of supramolecular fiber organization	54/1434	383/18723	9.40e-06	2.66e-04	54
GO:005149513	Breast	IDC	positive regulation of cytoskeleton organization	35/1434	226/18723	5.04e-05	1.09e-03	35
GO:004206014	Breast	IDC	wound healing	55/1434	422/18723	7.27e-05	1.45e-03	55
GO:003295614	Breast	IDC	regulation of actin cytoskeleton organization	48/1434	358/18723	1.03e-04	1.96e-03	48
GO:000701514	Breast	IDC	actin filament organization	55/1434	442/18723	2.45e-04	3.84e-03	55

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

DST

SNV

Missense_Mutation

novel

c.3443N>T

p.Glu1148Val

p.E1148V

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-A2-A0CR-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

DST

SNV

Missense_Mutation

novel

c.3442N>C

p.Glu1148Gln

p.E1148Q

protein_coding

deleterious(0)

probably_damaging(0.998)

TCGA-A2-A0CR-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

DST

SNV

Missense_Mutation

c.10900N>A

p.Gln3634Lys

p.Q3634K

protein_coding

deleterious(0.02)

benign(0.054)

TCGA-A2-A1FZ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unspecific

Arimidex

DST

SNV

Missense_Mutation

c.6277N>A

p.Glu2093Lys

p.E2093K

protein_coding

tolerated(0.09)

benign(0.087)

TCGA-A8-A06X-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DST

SNV

Missense_Mutation

c.15809C>A

p.Ser5270Tyr

p.S5270Y

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-A8-A09W-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Unknown

DST

SNV

Missense_Mutation

c.9694N>T

p.Gly3232Trp

p.G3232W

protein_coding

deleterious(0.01)

probably_damaging(0.914)

TCGA-A8-A09Z-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DST

SNV

Missense_Mutation

rs758278474

c.7219G>A

p.Ala2407Thr

p.A2407T

protein_coding

tolerated(0.54)

benign(0.011)

TCGA-AC-A23H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DST

SNV

Missense_Mutation

c.6166G>C

p.Ala2056Pro

p.A2056P

protein_coding

tolerated(0.44)

possibly_damaging(0.72)

TCGA-AC-A23H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DST

SNV

Missense_Mutation

rs772972201

c.8893G>A

p.Val2965Ile

p.V2965I

protein_coding

tolerated(0.05)

benign(0.273)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DST

SNV

Missense_Mutation

c.5275G>A

p.Glu1759Lys

p.E1759K

protein_coding

tolerated(0.43)

benign(0.404)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1