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Gene: DSC1 |
Gene summary for DSC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DSC1 | Gene ID | 1823 |
Gene name | desmocollin 1 | |
Gene Alias | CDHF1 | |
Cytomap | 18q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q08554 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1823 | DSC1 | HCC1 | Human | Liver | HCC | 5.16e-13 | 1.15e+00 | 0.5336 |
1823 | DSC1 | HCC2 | Human | Liver | HCC | 1.25e-18 | 1.60e+00 | 0.5341 |
1823 | DSC1 | HCC5 | Human | Liver | HCC | 3.75e-13 | 1.06e+00 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
DSC1 | DSG1 | DSC1_DSG1 | DESMOSOME | HNSCC | OSCC |
DSC1 | DSG2 | DSC1_DSG2 | DESMOSOME | HNSCC | OSCC |
DSC1 | DSG1 | DSC1_DSG1 | DESMOSOME | Skin | ADJ |
DSC1 | DSG2 | DSC1_DSG2 | DESMOSOME | Skin | ADJ |
DSC1 | DSG1 | DSC1_DSG1 | DESMOSOME | Skin | AK |
DSC1 | DSG2 | DSC1_DSG2 | DESMOSOME | Skin | AK |
DSC1 | DSG1 | DSC1_DSG1 | DESMOSOME | Skin | Healthy |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DSC1 | SNV | Missense_Mutation | c.59N>C | p.Leu20Pro | p.L20P | Q08554 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
DSC1 | SNV | Missense_Mutation | novel | c.1241N>A | p.Gly414Glu | p.G414E | Q08554 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
DSC1 | SNV | Missense_Mutation | novel | c.165T>G | p.Cys55Trp | p.C55W | Q08554 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-HN-A2NL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
DSC1 | SNV | Missense_Mutation | novel | c.889N>T | p.His297Tyr | p.H297Y | Q08554 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-OL-A97C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DSC1 | insertion | Frame_Shift_Ins | novel | c.2315_2316insAAATGCTAATACTTCCTTGAAACTTCATCTGAGA | p.Gly773AsnfsTer20 | p.G773Nfs*20 | Q08554 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DSC1 | insertion | Frame_Shift_Ins | novel | c.220_221insTGGCAGAGCCATTTACAAACTTTTATAAAGATGA | p.Asp74ValfsTer20 | p.D74Vfs*20 | Q08554 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
DSC1 | insertion | Frame_Shift_Ins | novel | c.2171_2172insCAAAA | p.Pro725LysfsTer6 | p.P725Kfs*6 | Q08554 | protein_coding | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
DSC1 | insertion | In_Frame_Ins | novel | c.2170_2171insCTTTGTGTGGTTATGAAGTCCTGGCTA | p.Phe724delinsSerLeuCysGlyTyrGluValLeuAlaIle | p.F724delinsSLCGYEVLAI | Q08554 | protein_coding | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
DSC1 | SNV | Missense_Mutation | c.2572N>G | p.Leu858Val | p.L858V | Q08554 | protein_coding | tolerated(1) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DSC1 | SNV | Missense_Mutation | novel | c.2381N>T | p.Gly794Val | p.G794V | Q08554 | protein_coding | deleterious(0.01) | possibly_damaging(0.906) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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