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Gene: DRAIC |
Gene summary for DRAIC |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DRAIC | Gene ID | 145837 |
| Gene name | downregulated RNA in cancer, inhibitor of cell invasion and migration | |
| Gene Alias | DRAIC | |
| Cytomap | 15q23 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 145837 | DRAIC | A002-C-021 | Human | Colorectum | FAP | 1.00e-04 | 2.90e-01 | 0.1171 |
| 145837 | DRAIC | A015-C-202 | Human | Colorectum | FAP | 6.05e-25 | 8.38e-01 | -0.0849 |
| 145837 | DRAIC | A008-E-015 | Human | Colorectum | FAP | 5.84e-03 | 3.09e-01 | 0.0177 |
| 145837 | DRAIC | S43 | Human | Liver | Cirrhotic | 1.93e-02 | -7.41e-02 | -0.0187 |
| 145837 | DRAIC | HCC1_Meng | Human | Liver | HCC | 4.79e-21 | -1.48e-02 | 0.0246 |
| 145837 | DRAIC | HCC1 | Human | Liver | HCC | 3.68e-16 | 8.53e-01 | 0.5336 |
| 145837 | DRAIC | HCC2 | Human | Liver | HCC | 3.35e-24 | 5.03e+00 | 0.5341 |
| 145837 | DRAIC | Pt13.a | Human | Liver | HCC | 9.14e-03 | -7.41e-02 | 0.021 |
| 145837 | DRAIC | Pt14.d | Human | Liver | HCC | 1.93e-02 | -7.41e-02 | 0.0143 |
| 145837 | DRAIC | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.69e-09 | 5.07e-01 | -0.2116 |
| 145837 | DRAIC | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.20e-06 | 5.97e-01 | -0.2107 |
| 145837 | DRAIC | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.31e-08 | 4.80e-01 | -0.2119 |
| 145837 | DRAIC | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.51e-02 | 1.76e-01 | -0.0166 |
| 145837 | DRAIC | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.06e-02 | 1.56e-01 | -0.0132 |
| 145837 | DRAIC | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.30e-03 | 1.92e-01 | -0.013 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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