Tissue | Expression Dynamics | Abbreviation |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/DPP4_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DPP4_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DPP4_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DPP4_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:004440322 | Liver | HCC | biological process involved in symbiotic interaction | 183/7958 | 290/18723 | 9.13e-13 | 4.59e-11 | 183 |
GO:005170122 | Liver | HCC | biological process involved in interaction with host | 128/7958 | 203/18723 | 2.51e-09 | 6.91e-08 | 128 |
GO:005212612 | Liver | HCC | movement in host environment | 109/7958 | 175/18723 | 9.58e-08 | 1.89e-06 | 109 |
GO:000166612 | Liver | HCC | response to hypoxia | 172/7958 | 307/18723 | 1.06e-06 | 1.59e-05 | 172 |
GO:003629312 | Liver | HCC | response to decreased oxygen levels | 179/7958 | 322/18723 | 1.29e-06 | 1.87e-05 | 179 |
GO:007048212 | Liver | HCC | response to oxygen levels | 191/7958 | 347/18723 | 1.42e-06 | 2.03e-05 | 191 |
GO:004440912 | Liver | HCC | entry into host | 88/7958 | 151/18723 | 6.47e-05 | 5.91e-04 | 88 |
GO:004671812 | Liver | HCC | viral entry into host cell | 83/7958 | 144/18723 | 1.73e-04 | 1.36e-03 | 83 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
GO:003559212 | Liver | HCC | establishment of protein localization to extracellular region | 176/7958 | 360/18723 | 7.96e-03 | 3.15e-02 | 176 |
GO:000930612 | Liver | HCC | protein secretion | 175/7958 | 359/18723 | 9.32e-03 | 3.57e-02 | 175 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
GO:00160328 | Lung | IAC | viral process | 94/2061 | 415/18723 | 5.11e-12 | 4.27e-09 | 94 |
GO:00190588 | Lung | IAC | viral life cycle | 77/2061 | 317/18723 | 1.23e-11 | 4.83e-09 | 77 |
GO:00521268 | Lung | IAC | movement in host environment | 48/2061 | 175/18723 | 1.30e-09 | 2.21e-07 | 48 |
GO:00517018 | Lung | IAC | biological process involved in interaction with host | 52/2061 | 203/18723 | 3.74e-09 | 5.84e-07 | 52 |
GO:00467188 | Lung | IAC | viral entry into host cell | 41/2061 | 144/18723 | 6.27e-09 | 9.08e-07 | 41 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPP4 | SNV | Missense_Mutation | novel | c.1444N>A | p.Leu482Ile | p.L482I | P27487 | protein_coding | deleterious(0.05) | benign(0.258) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP4 | SNV | Missense_Mutation | rs755540270 | c.1051N>G | p.Thr351Ala | p.T351A | P27487 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD |
DPP4 | SNV | Missense_Mutation | | c.1394N>T | p.Ala465Val | p.A465V | P27487 | protein_coding | deleterious(0.01) | possibly_damaging(0.675) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
DPP4 | SNV | Missense_Mutation | | c.2222N>A | p.Gly741Glu | p.G741E | P27487 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-B6-A0X1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DPP4 | SNV | Missense_Mutation | | c.779N>C | p.Gly260Ala | p.G260A | P27487 | protein_coding | deleterious(0.01) | probably_damaging(0.928) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
DPP4 | SNV | Missense_Mutation | novel | c.1493N>T | p.Ser498Leu | p.S498L | P27487 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
DPP4 | SNV | Missense_Mutation | rs752793888 | c.1067N>A | p.Arg356Lys | p.R356K | P27487 | protein_coding | tolerated(0.52) | benign(0.084) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP4 | SNV | Missense_Mutation | | c.67N>A | p.Val23Met | p.V23M | P27487 | protein_coding | tolerated(0.16) | probably_damaging(0.988) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DPP4 | deletion | Frame_Shift_Del | rs779957190 | c.135_138delAACT | p.Thr46IlefsTer3 | p.T46Ifs*3 | P27487 | protein_coding | | | TCGA-A2-A3XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamyicin | CR |
DPP4 | SNV | Missense_Mutation | | c.2072N>C | p.Arg691Thr | p.R691T | P27487 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL2105762 | OMARIGLIPTIN | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | VILDAGLIPTIN | VILDAGLIPTIN | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | Beta-phe compound 2 | | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | Imidazo cyclohexylamine derivative 3 | | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | Peptide analog 47 | | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | ENALAPRIL | ENALAPRIL | 16678199 |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | Dutogliptin | DUTOGLIPTIN | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL3833357 | BEGELOMAB | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | inhibitor | 363894186 | TALABOSTAT | |
1803 | DPP4 | PROTEASE, CELL SURFACE, DRUGGABLE GENOME, ENZYME | | PMID25482888-Compound-52 | | |