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Gene: DPP3 |
Gene summary for DPP3 |
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Gene information | Species | Human | Gene symbol | DPP3 | Gene ID | 10072 |
Gene name | dipeptidyl peptidase 3 | |
Gene Alias | DPPIII | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NY33 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10072 | DPP3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.22e-07 | 3.87e-01 | -0.1808 |
10072 | DPP3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.16e-02 | 2.48e-01 | -0.0811 |
10072 | DPP3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.99e-11 | 3.74e-01 | -0.1954 |
10072 | DPP3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.15e-07 | 7.13e-01 | -0.2602 |
10072 | DPP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.25e-03 | 3.09e-01 | -0.1207 |
10072 | DPP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.74e-06 | 2.48e-01 | -0.1464 |
10072 | DPP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-04 | 2.03e-01 | -0.1001 |
10072 | DPP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.93e-10 | 4.28e-01 | -0.059 |
10072 | DPP3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.71e-02 | 2.00e-01 | -0.0842 |
10072 | DPP3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.33e-06 | 3.10e-01 | 0.096 |
10072 | DPP3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.35e-03 | 3.05e-01 | 0.0528 |
10072 | DPP3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.92e-02 | 3.47e-01 | 0.0131 |
10072 | DPP3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.31e-11 | 3.35e-01 | 0.0674 |
10072 | DPP3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.67e-02 | 2.62e-01 | 0.0588 |
10072 | DPP3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.06e-07 | 3.04e-01 | 0.294 |
10072 | DPP3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.15e-05 | 7.47e-01 | 0.3487 |
10072 | DPP3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.07e-02 | 2.07e-01 | 0.281 |
10072 | DPP3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.16e-13 | 4.66e-01 | 0.3859 |
10072 | DPP3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.12e-06 | 2.51e-01 | 0.3005 |
10072 | DPP3 | LZE4T | Human | Esophagus | ESCC | 7.60e-09 | 2.89e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPP3 | SNV | Missense_Mutation | c.2081C>A | p.Ala694Asp | p.A694D | Q9NY33 | protein_coding | tolerated(0.35) | benign(0.121) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
DPP3 | SNV | Missense_Mutation | rs775773853 | c.2108N>A | p.Arg703His | p.R703H | Q9NY33 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
DPP3 | insertion | Frame_Shift_Ins | novel | c.841_842insCTCGGCTCACTGAAACCTCCACCTCCCAGGTTCAAGCA | p.Tyr281SerfsTer15 | p.Y281Sfs*15 | Q9NY33 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
DPP3 | insertion | In_Frame_Ins | novel | c.707_708insAGC | p.Ser236delinsArgAla | p.S236delinsRA | Q9NY33 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
DPP3 | insertion | In_Frame_Ins | novel | c.709_710insCCCGAGTAGCTGGCATGACAGGCACCTACCACCATGCCC | p.Tyr237delinsSerArgValAlaGlyMetThrGlyThrTyrHisHisAlaHis | p.Y237delinsSRVAGMTGTYHHAH | Q9NY33 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
DPP3 | SNV | Missense_Mutation | rs778551062 | c.596N>A | p.Arg199Gln | p.R199Q | Q9NY33 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DPP3 | SNV | Missense_Mutation | novel | c.88G>A | p.Glu30Lys | p.E30K | Q9NY33 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
DPP3 | SNV | Missense_Mutation | novel | c.554N>G | p.Gln185Arg | p.Q185R | Q9NY33 | protein_coding | deleterious(0.04) | possibly_damaging(0.696) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
DPP3 | SNV | Missense_Mutation | novel | c.130G>A | p.Gly44Arg | p.G44R | Q9NY33 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DPP3 | SNV | Missense_Mutation | rs777823683 | c.1715G>A | p.Arg572Gln | p.R572Q | Q9NY33 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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