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Gene: DPH2 |
Gene summary for DPH2 |
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Gene information | Species | Human | Gene symbol | DPH2 | Gene ID | 1802 |
Gene name | diphthamide biosynthesis 2 | |
Gene Alias | DPH2L2 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | Q9BQC3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1802 | DPH2 | LZE4T | Human | Esophagus | ESCC | 1.62e-06 | 7.58e-02 | 0.0811 |
1802 | DPH2 | LZE7T | Human | Esophagus | ESCC | 9.75e-03 | 2.28e-01 | 0.0667 |
1802 | DPH2 | LZE22T | Human | Esophagus | ESCC | 5.98e-03 | 1.37e-01 | 0.068 |
1802 | DPH2 | LZE24T | Human | Esophagus | ESCC | 1.91e-13 | 2.93e-01 | 0.0596 |
1802 | DPH2 | LZE6T | Human | Esophagus | ESCC | 2.24e-02 | 1.33e-01 | 0.0845 |
1802 | DPH2 | P2T-E | Human | Esophagus | ESCC | 1.24e-11 | 2.60e-01 | 0.1177 |
1802 | DPH2 | P4T-E | Human | Esophagus | ESCC | 3.86e-16 | 2.05e-01 | 0.1323 |
1802 | DPH2 | P5T-E | Human | Esophagus | ESCC | 1.51e-12 | 2.64e-01 | 0.1327 |
1802 | DPH2 | P8T-E | Human | Esophagus | ESCC | 8.41e-10 | 1.17e-01 | 0.0889 |
1802 | DPH2 | P9T-E | Human | Esophagus | ESCC | 8.93e-10 | 1.46e-01 | 0.1131 |
1802 | DPH2 | P10T-E | Human | Esophagus | ESCC | 9.52e-25 | 4.57e-01 | 0.116 |
1802 | DPH2 | P11T-E | Human | Esophagus | ESCC | 6.04e-09 | 3.47e-01 | 0.1426 |
1802 | DPH2 | P12T-E | Human | Esophagus | ESCC | 8.72e-12 | 1.32e-01 | 0.1122 |
1802 | DPH2 | P15T-E | Human | Esophagus | ESCC | 1.66e-20 | 1.97e-01 | 0.1149 |
1802 | DPH2 | P16T-E | Human | Esophagus | ESCC | 7.74e-19 | 2.14e-01 | 0.1153 |
1802 | DPH2 | P17T-E | Human | Esophagus | ESCC | 1.10e-11 | 2.44e-01 | 0.1278 |
1802 | DPH2 | P19T-E | Human | Esophagus | ESCC | 2.62e-04 | 4.07e-01 | 0.1662 |
1802 | DPH2 | P20T-E | Human | Esophagus | ESCC | 2.39e-20 | 2.64e-01 | 0.1124 |
1802 | DPH2 | P21T-E | Human | Esophagus | ESCC | 5.04e-25 | 5.21e-01 | 0.1617 |
1802 | DPH2 | P22T-E | Human | Esophagus | ESCC | 2.42e-05 | 1.14e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000218120 | Oral cavity | OSCC | cytoplasmic translation | 133/7305 | 148/18723 | 1.94e-38 | 2.46e-35 | 133 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
GO:0002181110 | Oral cavity | LP | cytoplasmic translation | 124/4623 | 148/18723 | 5.09e-52 | 3.19e-48 | 124 |
GO:0006417110 | Oral cavity | LP | regulation of translation | 175/4623 | 468/18723 | 4.49e-10 | 2.22e-08 | 175 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
GO:000218129 | Skin | cSCC | cytoplasmic translation | 127/4864 | 148/18723 | 4.83e-53 | 7.57e-50 | 127 |
GO:000641729 | Skin | cSCC | regulation of translation | 226/4864 | 468/18723 | 8.78e-26 | 2.62e-23 | 226 |
GO:000641423 | Skin | cSCC | translational elongation | 30/4864 | 55/18723 | 6.13e-06 | 8.70e-05 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPH2 | SNV | Missense_Mutation | c.320N>A | p.Gly107Asp | p.G107D | Q9BQC3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
DPH2 | insertion | Nonsense_Mutation | novel | c.1070_1071insAGCCCTGACCCAGACCTTGACCCAGACCTGAGTCGGCTGCTCT | p.Ile358AlafsTer10 | p.I358Afs*10 | Q9BQC3 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
DPH2 | insertion | In_Frame_Ins | novel | c.202_203insCATCCCTCCCTTCCACCTACTACGTGGGGCAGA | p.Ala67_Arg68insProSerLeuProSerThrTyrTyrValGlyGln | p.A67_R68insPSLPSTYYVGQ | Q9BQC3 | protein_coding | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
DPH2 | SNV | Missense_Mutation | c.637N>C | p.Glu213Gln | p.E213Q | Q9BQC3 | protein_coding | deleterious(0.01) | possibly_damaging(0.492) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
DPH2 | SNV | Missense_Mutation | novel | c.535N>G | p.Ser179Gly | p.S179G | Q9BQC3 | protein_coding | tolerated(0.24) | benign(0.122) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
DPH2 | SNV | Missense_Mutation | novel | c.687N>G | p.Asp229Glu | p.D229E | Q9BQC3 | protein_coding | tolerated(0.45) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DPH2 | SNV | Missense_Mutation | novel | c.1067N>T | p.Gln356Leu | p.Q356L | Q9BQC3 | protein_coding | deleterious(0) | benign(0.023) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DPH2 | SNV | Missense_Mutation | rs750812731 | c.910C>T | p.Arg304Trp | p.R304W | Q9BQC3 | protein_coding | deleterious(0) | possibly_damaging(0.745) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DPH2 | SNV | Missense_Mutation | c.1216G>A | p.Glu406Lys | p.E406K | Q9BQC3 | protein_coding | tolerated(0.07) | benign(0.037) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DPH2 | SNV | Missense_Mutation | rs760454990 | c.1444N>A | p.Ala482Thr | p.A482T | Q9BQC3 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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