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Gene: DPH1 |
Gene summary for DPH1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DPH1 | Gene ID | 1801 |
| Gene name | diphthamide biosynthesis 1 | |
| Gene Alias | DEDSSH | |
| Cytomap | 17p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | Q9BZG8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1801 | DPH1 | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.13e-01 | 0.082 |
| 1801 | DPH1 | LZE4T | Human | Esophagus | ESCC | 3.08e-23 | 6.13e-01 | 0.0811 |
| 1801 | DPH1 | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 2.82e-01 | 0.0667 |
| 1801 | DPH1 | LZE8T | Human | Esophagus | ESCC | 4.02e-05 | 1.87e-01 | 0.067 |
| 1801 | DPH1 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.62e-01 | 0.0662 |
| 1801 | DPH1 | LZE22D1 | Human | Esophagus | HGIN | 1.90e-05 | 2.54e-01 | 0.0595 |
| 1801 | DPH1 | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 2.49e-01 | 0.068 |
| 1801 | DPH1 | LZE24T | Human | Esophagus | ESCC | 3.48e-41 | 8.61e-01 | 0.0596 |
| 1801 | DPH1 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.04e-01 | 0.0655 |
| 1801 | DPH1 | P1T-E | Human | Esophagus | ESCC | 5.75e-15 | 4.45e-01 | 0.0875 |
| 1801 | DPH1 | P2T-E | Human | Esophagus | ESCC | 6.38e-31 | 4.59e-01 | 0.1177 |
| 1801 | DPH1 | P4T-E | Human | Esophagus | ESCC | 4.48e-22 | 4.63e-01 | 0.1323 |
| 1801 | DPH1 | P5T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.82e-01 | 0.1327 |
| 1801 | DPH1 | P8T-E | Human | Esophagus | ESCC | 1.46e-28 | 4.35e-01 | 0.0889 |
| 1801 | DPH1 | P9T-E | Human | Esophagus | ESCC | 8.16e-12 | 2.38e-01 | 0.1131 |
| 1801 | DPH1 | P10T-E | Human | Esophagus | ESCC | 1.47e-14 | 3.46e-01 | 0.116 |
| 1801 | DPH1 | P11T-E | Human | Esophagus | ESCC | 2.96e-18 | 6.39e-01 | 0.1426 |
| 1801 | DPH1 | P12T-E | Human | Esophagus | ESCC | 1.31e-36 | 6.08e-01 | 0.1122 |
| 1801 | DPH1 | P15T-E | Human | Esophagus | ESCC | 7.07e-10 | 2.28e-01 | 0.1149 |
| 1801 | DPH1 | P16T-E | Human | Esophagus | ESCC | 1.05e-38 | 6.40e-01 | 0.1153 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
| GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
| GO:000641418 | Esophagus | HGIN | translational elongation | 22/2587 | 55/18723 | 1.46e-06 | 5.56e-05 | 22 |
| GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
| GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
| GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DPH1 | SNV | Missense_Mutation | novel | c.341C>G | p.Ala114Gly | p.A114G | Q9BZG8 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| DPH1 | SNV | Missense_Mutation | rs750137688 | c.299C>T | p.Thr100Met | p.T100M | Q9BZG8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| DPH1 | insertion | In_Frame_Ins | novel | c.343_344insCCAGGAGCGGCTGCCAGGCTGGGGCAG | p.Cys115delinsSerArgSerGlyCysGlnAlaGlyAlaGly | p.C115delinsSRSGCQAGAG | Q9BZG8 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| DPH1 | SNV | Missense_Mutation | rs371816907 | c.757N>A | p.Ala253Thr | p.A253T | Q9BZG8 | protein_coding | deleterious(0.04) | benign(0.041) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| DPH1 | SNV | Missense_Mutation | novel | c.712C>A | p.Arg238Ser | p.R238S | Q9BZG8 | protein_coding | deleterious(0) | benign(0.157) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| DPH1 | SNV | Missense_Mutation | rs753008362 | c.79C>T | p.Arg27Trp | p.R27W | Q9BZG8 | protein_coding | deleterious(0) | possibly_damaging(0.492) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
| DPH1 | SNV | Missense_Mutation | rs769281060 | c.661N>C | p.Ser221Pro | p.S221P | Q9BZG8 | protein_coding | deleterious(0) | benign(0.297) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| DPH1 | SNV | Missense_Mutation | rs371816907 | c.757N>A | p.Ala253Thr | p.A253T | Q9BZG8 | protein_coding | deleterious(0.04) | benign(0.041) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| DPH1 | SNV | Missense_Mutation | rs764906514 | c.935N>A | p.Arg312Gln | p.R312Q | Q9BZG8 | protein_coding | tolerated(0.39) | benign(0.015) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| DPH1 | SNV | Missense_Mutation | rs757704030 | c.59G>A | p.Arg20Gln | p.R20Q | Q9BZG8 | protein_coding | tolerated(0.15) | benign(0) | TCGA-A5-A2K4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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