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Gene: DPCR1 |
Gene summary for DPCR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DPCR1 | Gene ID | 135656 |
| Gene name | mucin like 3 | |
| Gene Alias | C6orf37 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | E9PEI6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 135656 | DPCR1 | Pat01-B | Human | Stomach | GC | 4.57e-15 | -6.21e-01 | 0.5754 |
| 135656 | DPCR1 | Pat02-B | Human | Stomach | GC | 3.11e-14 | -6.21e-01 | 0.0368 |
| 135656 | DPCR1 | Pat03-B | Human | Stomach | GC | 1.62e-12 | -6.21e-01 | 0.3693 |
| 135656 | DPCR1 | Pat04-B | Human | Stomach | GC | 2.00e-05 | -6.21e-01 | -0.1483 |
| 135656 | DPCR1 | Pat05-B | Human | Stomach | GC | 7.89e-05 | -6.21e-01 | -0.0353 |
| 135656 | DPCR1 | Pat06-B | Human | Stomach | GC | 1.81e-12 | -6.21e-01 | -0.1961 |
| 135656 | DPCR1 | Pat07-B | Human | Stomach | GC | 4.67e-02 | -6.21e-01 | 0.0935 |
| 135656 | DPCR1 | Pat08-B | Human | Stomach | GC | 8.41e-04 | -6.21e-01 | 0.0182 |
| 135656 | DPCR1 | Pat09-B | Human | Stomach | GC | 2.25e-10 | -6.21e-01 | -0.0359 |
| 135656 | DPCR1 | Pat11-B | Human | Stomach | GC | 3.78e-04 | -6.21e-01 | -0.182 |
| 135656 | DPCR1 | Pat12-B | Human | Stomach | GC | 1.29e-13 | -6.21e-01 | 0.0325 |
| 135656 | DPCR1 | Pat13-B | Human | Stomach | GC | 1.89e-06 | -6.21e-01 | 0.0555 |
| 135656 | DPCR1 | Pat15-B | Human | Stomach | GC | 2.88e-10 | -6.21e-01 | -0.0778 |
| 135656 | DPCR1 | Pat16-B | Human | Stomach | GC | 3.11e-14 | -6.21e-01 | 0.1918 |
| 135656 | DPCR1 | Pat17-B | Human | Stomach | GC | 6.94e-14 | -6.21e-01 | 0.3109 |
| 135656 | DPCR1 | Pat18-B | Human | Stomach | GC | 8.98e-12 | -6.21e-01 | -0.0432 |
| 135656 | DPCR1 | Pat19-B | Human | Stomach | GC | 2.24e-08 | -6.21e-01 | 0.0826 |
| 135656 | DPCR1 | Pat22-B | Human | Stomach | GC | 9.58e-11 | -6.21e-01 | -0.1042 |
| 135656 | DPCR1 | Pat24-B | Human | Stomach | GC | 2.53e-06 | -6.21e-01 | -0.1184 |
| 135656 | DPCR1 | Pat25-A | Human | Stomach | CAG with IM | 6.94e-14 | -6.21e-01 | -0.1648 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DPCR1 | SNV | Missense_Mutation | c.1139C>T | p.Pro380Leu | p.P380L | protein_coding | deleterious(0.01) | possibly_damaging(0.833) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | ||
| DPCR1 | SNV | Missense_Mutation | c.314N>G | p.Thr105Ser | p.T105S | protein_coding | tolerated_low_confidence(0.14) | benign(0.021) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||
| DPCR1 | SNV | Missense_Mutation | rs112148530 | c.1241N>T | p.Thr414Ile | p.T414I | protein_coding | tolerated(0.1) | probably_damaging(0.976) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | c.2568C>G | p.Phe856Leu | p.F856L | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| DPCR1 | SNV | Missense_Mutation | novel | c.384A>C | p.Gln128His | p.Q128H | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.3448A>C | p.Lys1150Gln | p.K1150Q | protein_coding | tolerated(0.3) | possibly_damaging(0.631) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DPCR1 | SNV | Missense_Mutation | novel | c.3452N>A | p.Arg1151Lys | p.R1151K | protein_coding | tolerated(1) | benign(0.086) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD | |
| DPCR1 | SNV | Missense_Mutation | c.2557N>G | p.Thr853Ala | p.T853A | protein_coding | deleterious(0.04) | benign(0.38) | TCGA-B6-A0WX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
| DPCR1 | SNV | Missense_Mutation | c.196C>T | p.His66Tyr | p.H66Y | protein_coding | deleterious(0) | benign(0.047) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | ||
| DPCR1 | SNV | Missense_Mutation | rs761214945 | c.1456N>C | p.Thr486Pro | p.T486P | protein_coding | tolerated(0.18) | probably_damaging(0.958) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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