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Gene: DOPEY1 |
Gene summary for DOPEY1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DOPEY1 | Gene ID | 23033 |
| Gene name | DOP1 leucine zipper like protein A | |
| Gene Alias | DOP1 | |
| Cytomap | 6q14.1 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TA12 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23033 | DOPEY1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-41 | -8.93e-01 | 0.0155 |
| 23033 | DOPEY1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.62e-25 | -8.93e-01 | -0.1808 |
| 23033 | DOPEY1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.04e-06 | -8.93e-01 | 0.0216 |
| 23033 | DOPEY1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.46e-20 | -8.93e-01 | -0.0811 |
| 23033 | DOPEY1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-29 | -8.93e-01 | -0.1088 |
| 23033 | DOPEY1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-44 | -8.93e-01 | -0.1954 |
| 23033 | DOPEY1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.2602 |
| 23033 | DOPEY1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.13e-06 | -8.93e-01 | -0.2196 |
| 23033 | DOPEY1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-20 | -8.93e-01 | -0.1207 |
| 23033 | DOPEY1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.50e-17 | -8.93e-01 | -0.1526 |
| 23033 | DOPEY1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-62 | -8.93e-01 | -0.1464 |
| 23033 | DOPEY1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.40e-59 | -8.93e-01 | -0.1001 |
| 23033 | DOPEY1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.72e-34 | -8.93e-01 | -0.059 |
| 23033 | DOPEY1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-08 | -8.93e-01 | -0.1706 |
| 23033 | DOPEY1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-09 | -8.93e-01 | -0.2061 |
| 23033 | DOPEY1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.04e-06 | -8.93e-01 | -0.1462 |
| 23033 | DOPEY1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.96e-15 | -8.93e-01 | -0.0842 |
| 23033 | DOPEY1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.00410000000000005 |
| 23033 | DOPEY1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.51e-12 | -8.93e-01 | -0.0179 |
| 23033 | DOPEY1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.39e-37 | -8.93e-01 | 0.096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DOPEY1 | SNV | Missense_Mutation | rs763170333 | c.1338N>C | p.Gln446His | p.Q446H | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | c.6361C>A | p.His2121Asn | p.H2121N | protein_coding | tolerated(0.06) | possibly_damaging(0.708) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| DOPEY1 | SNV | Missense_Mutation | novel | c.7336A>C | p.Lys2446Gln | p.K2446Q | protein_coding | tolerated(0.07) | benign(0.034) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | c.6047N>T | p.Thr2016Ile | p.T2016I | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| DOPEY1 | SNV | Missense_Mutation | novel | c.5461A>C | p.Ile1821Leu | p.I1821L | protein_coding | tolerated(0.19) | benign(0.187) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| DOPEY1 | SNV | Missense_Mutation | c.6303A>T | p.Glu2101Asp | p.E2101D | protein_coding | tolerated(0.12) | probably_damaging(0.999) | TCGA-C8-A1HG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DOPEY1 | SNV | Missense_Mutation | rs149059542 | c.1562N>G | p.Thr521Arg | p.T521R | protein_coding | deleterious(0) | benign(0.361) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
| DOPEY1 | SNV | Missense_Mutation | novel | c.3487A>C | p.Thr1163Pro | p.T1163P | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
| DOPEY1 | SNV | Missense_Mutation | rs368200841 | c.4399G>A | p.Ala1467Thr | p.A1467T | protein_coding | tolerated(0.62) | benign(0) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| DOPEY1 | SNV | Missense_Mutation | novel | c.5129N>G | p.Met1710Arg | p.M1710R | protein_coding | deleterious(0) | benign(0.207) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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