|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: DOP1B |
Gene summary for DOP1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DOP1B | Gene ID | 9980 |
| Gene name | DOP1 leucine zipper like protein B | |
| Gene Alias | 21orf5 | |
| Cytomap | 21q22.12 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y3R5 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9980 | DOP1B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.51e-27 | 5.08e-01 | 0.0155 |
| 9980 | DOP1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.80e-32 | 7.77e-01 | -0.1808 |
| 9980 | DOP1B | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-08 | 5.15e-01 | 0.0216 |
| 9980 | DOP1B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.25e-38 | 9.39e-01 | -0.0811 |
| 9980 | DOP1B | HTA11_78_2000001011 | Human | Colorectum | AD | 6.39e-41 | 9.96e-01 | -0.1088 |
| 9980 | DOP1B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-82 | 1.41e+00 | -0.1954 |
| 9980 | DOP1B | HTA11_411_2000001011 | Human | Colorectum | SER | 9.56e-24 | 1.66e+00 | -0.2602 |
| 9980 | DOP1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.50e-21 | 1.26e+00 | -0.2196 |
| 9980 | DOP1B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.99e-33 | 8.73e-01 | -0.1207 |
| 9980 | DOP1B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.40e-25 | 7.89e-01 | -0.1526 |
| 9980 | DOP1B | HTA11_696_2000001011 | Human | Colorectum | AD | 5.69e-77 | 1.34e+00 | -0.1464 |
| 9980 | DOP1B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.41e-57 | 1.06e+00 | -0.1001 |
| 9980 | DOP1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.06e-39 | 9.23e-01 | -0.059 |
| 9980 | DOP1B | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.24e-14 | 8.48e-01 | -0.1706 |
| 9980 | DOP1B | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.32e-13 | 5.32e-01 | -0.2061 |
| 9980 | DOP1B | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.20e-14 | 6.08e-01 | -0.1462 |
| 9980 | DOP1B | HTA11_546_2000001011 | Human | Colorectum | AD | 9.46e-37 | 1.14e+00 | -0.0842 |
| 9980 | DOP1B | HTA11_9341_2000001011 | Human | Colorectum | SER | 7.44e-09 | 6.00e-01 | -0.00410000000000005 |
| 9980 | DOP1B | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.45e-14 | 4.36e-01 | -0.0179 |
| 9980 | DOP1B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.22e-19 | 4.20e-01 | 0.096 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
| GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
| GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
| GO:0007029 | Colorectum | AD | endoplasmic reticulum organization | 31/3918 | 87/18723 | 1.08e-03 | 1.00e-02 | 31 |
| GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
| GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
| GO:00068921 | Colorectum | SER | post-Golgi vesicle-mediated transport | 31/2897 | 104/18723 | 1.59e-04 | 3.08e-03 | 31 |
| GO:00070291 | Colorectum | SER | endoplasmic reticulum organization | 23/2897 | 87/18723 | 5.77e-03 | 4.23e-02 | 23 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |