Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DOP1A

Gene summary for DOP1A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DOP1A

Gene ID

23033

Gene nameDOP1 leucine zipper like protein A
Gene AliasDOP1
Cytomap6q14.1
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q5TA12


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23033DOP1AHTA11_3410_2000001011HumanColorectumAD2.84e-041.23e-010.0155
23033DOP1AHTA11_2487_2000001011HumanColorectumSER4.68e-082.32e-01-0.1808
23033DOP1AHTA11_1938_2000001011HumanColorectumAD3.85e-143.71e-01-0.0811
23033DOP1AHTA11_78_2000001011HumanColorectumAD5.51e-174.36e-01-0.1088
23033DOP1AHTA11_347_2000001011HumanColorectumAD7.14e-447.40e-01-0.1954
23033DOP1AHTA11_411_2000001011HumanColorectumSER1.20e-075.38e-01-0.2602
23033DOP1AHTA11_83_2000001011HumanColorectumSER2.45e-185.21e-01-0.1526
23033DOP1AHTA11_696_2000001011HumanColorectumAD1.75e-183.33e-01-0.1464
23033DOP1AHTA11_866_2000001011HumanColorectumAD2.10e-173.37e-01-0.1001
23033DOP1AHTA11_1391_2000001011HumanColorectumAD5.65e-195.24e-01-0.059
23033DOP1AHTA11_2992_2000001011HumanColorectumSER2.14e-073.56e-01-0.1706
23033DOP1AHTA11_5212_2000001011HumanColorectumAD2.28e-022.15e-01-0.2061
23033DOP1AHTA11_546_2000001011HumanColorectumAD1.56e-062.90e-01-0.0842
23033DOP1AHTA11_7862_2000001011HumanColorectumAD1.24e-021.98e-01-0.0179
23033DOP1AHTA11_866_3004761011HumanColorectumAD2.47e-041.42e-010.096
23033DOP1AHTA11_4255_2000001011HumanColorectumSER3.40e-032.52e-010.0446
23033DOP1AHTA11_10623_2000001011HumanColorectumAD8.98e-032.44e-01-0.0177
23033DOP1AHTA11_10711_2000001011HumanColorectumAD5.13e-082.30e-010.0338
23033DOP1AHTA11_7696_3000711011HumanColorectumAD8.44e-122.75e-010.0674
23033DOP1AHTA11_6818_2000001011HumanColorectumAD1.38e-073.60e-010.0112
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0048193ColorectumADGolgi vesicle transport109/3918296/187231.80e-101.68e-08109
GO:0016482ColorectumADcytosolic transport68/3918168/187236.00e-093.72e-0768
GO:0006892ColorectumADpost-Golgi vesicle-mediated transport45/3918104/187232.22e-079.26e-0645
GO:00481931ColorectumSERGolgi vesicle transport79/2897296/187234.20e-072.15e-0579
GO:00164821ColorectumSERcytosolic transport46/2897168/187235.20e-051.25e-0346
GO:00068921ColorectumSERpost-Golgi vesicle-mediated transport31/2897104/187231.59e-043.08e-0331
GO:00068926LungIACpost-Golgi vesicle-mediated transport27/2061104/187231.54e-054.49e-0427
GO:00164826LungIACcytosolic transport37/2061168/187232.74e-057.26e-0437
GO:00068952LungIACGolgi to endosome transport7/206117/187231.39e-031.53e-027
GO:00481937LungIACGolgi vesicle transport49/2061296/187232.35e-032.28e-0249
GO:000689212LungAISpost-Golgi vesicle-mediated transport26/1849104/187236.59e-062.93e-0426
GO:001648212LungAIScytosolic transport35/1849168/187231.57e-055.63e-0435
GO:00068951LungAISGolgi to endosome transport7/184917/187237.21e-041.04e-027
GO:004819312LungAISGolgi vesicle transport46/1849296/187231.32e-031.64e-0246
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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