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Gene: DOP1A |
Gene summary for DOP1A |
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Gene information | Species | Human | Gene symbol | DOP1A | Gene ID | 23033 |
Gene name | DOP1 leucine zipper like protein A | |
Gene Alias | DOP1 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TA12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23033 | DOP1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.84e-04 | 1.23e-01 | 0.0155 |
23033 | DOP1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.68e-08 | 2.32e-01 | -0.1808 |
23033 | DOP1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.85e-14 | 3.71e-01 | -0.0811 |
23033 | DOP1A | HTA11_78_2000001011 | Human | Colorectum | AD | 5.51e-17 | 4.36e-01 | -0.1088 |
23033 | DOP1A | HTA11_347_2000001011 | Human | Colorectum | AD | 7.14e-44 | 7.40e-01 | -0.1954 |
23033 | DOP1A | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.38e-01 | -0.2602 |
23033 | DOP1A | HTA11_83_2000001011 | Human | Colorectum | SER | 2.45e-18 | 5.21e-01 | -0.1526 |
23033 | DOP1A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.75e-18 | 3.33e-01 | -0.1464 |
23033 | DOP1A | HTA11_866_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.37e-01 | -0.1001 |
23033 | DOP1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.65e-19 | 5.24e-01 | -0.059 |
23033 | DOP1A | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.56e-01 | -0.1706 |
23033 | DOP1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.15e-01 | -0.2061 |
23033 | DOP1A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 2.90e-01 | -0.0842 |
23033 | DOP1A | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.98e-01 | -0.0179 |
23033 | DOP1A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.47e-04 | 1.42e-01 | 0.096 |
23033 | DOP1A | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | 0.0446 |
23033 | DOP1A | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.98e-03 | 2.44e-01 | -0.0177 |
23033 | DOP1A | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.13e-08 | 2.30e-01 | 0.0338 |
23033 | DOP1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.44e-12 | 2.75e-01 | 0.0674 |
23033 | DOP1A | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.38e-07 | 3.60e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00068921 | Colorectum | SER | post-Golgi vesicle-mediated transport | 31/2897 | 104/18723 | 1.59e-04 | 3.08e-03 | 31 |
GO:00068926 | Lung | IAC | post-Golgi vesicle-mediated transport | 27/2061 | 104/18723 | 1.54e-05 | 4.49e-04 | 27 |
GO:00164826 | Lung | IAC | cytosolic transport | 37/2061 | 168/18723 | 2.74e-05 | 7.26e-04 | 37 |
GO:00068952 | Lung | IAC | Golgi to endosome transport | 7/2061 | 17/18723 | 1.39e-03 | 1.53e-02 | 7 |
GO:00481937 | Lung | IAC | Golgi vesicle transport | 49/2061 | 296/18723 | 2.35e-03 | 2.28e-02 | 49 |
GO:000689212 | Lung | AIS | post-Golgi vesicle-mediated transport | 26/1849 | 104/18723 | 6.59e-06 | 2.93e-04 | 26 |
GO:001648212 | Lung | AIS | cytosolic transport | 35/1849 | 168/18723 | 1.57e-05 | 5.63e-04 | 35 |
GO:00068951 | Lung | AIS | Golgi to endosome transport | 7/1849 | 17/18723 | 7.21e-04 | 1.04e-02 | 7 |
GO:004819312 | Lung | AIS | Golgi vesicle transport | 46/1849 | 296/18723 | 1.32e-03 | 1.64e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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