![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DONSON |
Gene summary for DONSON |
![]() |
Gene information | Species | Human | Gene symbol | DONSON | Gene ID | 29980 |
Gene name | DNA replication fork stabilization factor DONSON | |
Gene Alias | B17 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9NYP3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29980 | DONSON | LZE24T | Human | Esophagus | ESCC | 8.85e-07 | 2.34e-01 | 0.0596 |
29980 | DONSON | P2T-E | Human | Esophagus | ESCC | 9.93e-18 | 2.41e-01 | 0.1177 |
29980 | DONSON | P4T-E | Human | Esophagus | ESCC | 5.64e-13 | 3.89e-01 | 0.1323 |
29980 | DONSON | P5T-E | Human | Esophagus | ESCC | 1.45e-05 | 2.33e-01 | 0.1327 |
29980 | DONSON | P8T-E | Human | Esophagus | ESCC | 1.22e-03 | 1.10e-01 | 0.0889 |
29980 | DONSON | P9T-E | Human | Esophagus | ESCC | 1.57e-03 | 1.44e-01 | 0.1131 |
29980 | DONSON | P10T-E | Human | Esophagus | ESCC | 5.75e-04 | 2.11e-01 | 0.116 |
29980 | DONSON | P11T-E | Human | Esophagus | ESCC | 7.97e-04 | 2.77e-01 | 0.1426 |
29980 | DONSON | P12T-E | Human | Esophagus | ESCC | 6.01e-14 | 2.46e-01 | 0.1122 |
29980 | DONSON | P16T-E | Human | Esophagus | ESCC | 6.65e-07 | 2.05e-01 | 0.1153 |
29980 | DONSON | P21T-E | Human | Esophagus | ESCC | 1.36e-11 | 2.54e-01 | 0.1617 |
29980 | DONSON | P22T-E | Human | Esophagus | ESCC | 4.55e-12 | 2.90e-01 | 0.1236 |
29980 | DONSON | P23T-E | Human | Esophagus | ESCC | 2.15e-11 | 3.31e-01 | 0.108 |
29980 | DONSON | P24T-E | Human | Esophagus | ESCC | 3.91e-04 | 1.57e-01 | 0.1287 |
29980 | DONSON | P26T-E | Human | Esophagus | ESCC | 3.57e-08 | 1.57e-01 | 0.1276 |
29980 | DONSON | P27T-E | Human | Esophagus | ESCC | 2.25e-10 | 3.52e-01 | 0.1055 |
29980 | DONSON | P28T-E | Human | Esophagus | ESCC | 8.39e-10 | 2.25e-01 | 0.1149 |
29980 | DONSON | P31T-E | Human | Esophagus | ESCC | 3.93e-09 | 2.69e-01 | 0.1251 |
29980 | DONSON | P32T-E | Human | Esophagus | ESCC | 1.44e-05 | 2.05e-01 | 0.1666 |
29980 | DONSON | P36T-E | Human | Esophagus | ESCC | 8.03e-03 | 1.86e-01 | 0.1187 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00000864 | Esophagus | ESCC | G2/M transition of mitotic cell cycle | 96/8552 | 137/18723 | 6.00e-09 | 1.23e-07 | 96 |
GO:00070934 | Esophagus | ESCC | mitotic cell cycle checkpoint | 90/8552 | 129/18723 | 2.49e-08 | 4.69e-07 | 90 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:004593013 | Esophagus | ESCC | negative regulation of mitotic cell cycle | 143/8552 | 235/18723 | 1.84e-06 | 2.15e-05 | 143 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:190199113 | Esophagus | ESCC | negative regulation of mitotic cell cycle phase transition | 112/8552 | 179/18723 | 3.69e-06 | 4.03e-05 | 112 |
GO:00103891 | Esophagus | ESCC | regulation of G2/M transition of mitotic cell cycle | 64/8552 | 94/18723 | 9.21e-06 | 8.82e-05 | 64 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DONSON | SNV | Missense_Mutation | novel | c.505C>G | p.Gln169Glu | p.Q169E | Q9NYP3 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DONSON | SNV | Missense_Mutation | novel | c.1239N>G | p.Asn413Lys | p.N413K | Q9NYP3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DONSON | SNV | Missense_Mutation | novel | c.1072N>A | p.Glu358Lys | p.E358K | Q9NYP3 | protein_coding | tolerated(0.05) | benign(0.136) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DONSON | SNV | Missense_Mutation | rs774052186 | c.631C>T | p.Arg211Cys | p.R211C | Q9NYP3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DONSON | SNV | Missense_Mutation | c.1428C>G | p.Ile476Met | p.I476M | Q9NYP3 | protein_coding | deleterious(0) | possibly_damaging(0.812) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DONSON | SNV | Missense_Mutation | c.961G>A | p.Glu321Lys | p.E321K | Q9NYP3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
DONSON | SNV | Missense_Mutation | novel | c.896N>A | p.Gly299Glu | p.G299E | Q9NYP3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
DONSON | SNV | Missense_Mutation | c.1394N>C | p.Arg465Thr | p.R465T | Q9NYP3 | protein_coding | deleterious(0.02) | benign(0.02) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
DONSON | SNV | Missense_Mutation | c.721N>C | p.Met241Leu | p.M241L | Q9NYP3 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DONSON | SNV | Missense_Mutation | c.1284N>T | p.Gln428His | p.Q428H | Q9NYP3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |