Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: DOCK9

Gene summary for DOCK9

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DOCK9

Gene ID

23348

Gene namededicator of cytokinesis 9
Gene AliasZIZ1
Cytomap13q32.3
Gene Typeprotein-coding
GO ID

GO:0007154

UniProtAcc

B3KXE2


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23348DOCK9CCI_1HumanCervixCC1.44e-121.14e+000.528
23348DOCK9CCI_2HumanCervixCC8.02e-211.59e+000.5249
23348DOCK9CCI_3HumanCervixCC1.71e-138.87e-010.516
23348DOCK9HTA11_3410_2000001011HumanColorectumAD1.12e-02-2.47e-010.0155
23348DOCK9HTA11_347_2000001011HumanColorectumAD1.31e-023.14e-01-0.1954
23348DOCK9HTA11_99999965104_69814HumanColorectumMSS1.10e-036.09e-010.281
23348DOCK9HTA11_99999971662_82457HumanColorectumMSS3.58e-067.01e-010.3859
23348DOCK9A015-C-203HumanColorectumFAP1.06e-16-4.18e-01-0.1294
23348DOCK9A002-C-201HumanColorectumFAP4.42e-08-3.34e-010.0324
23348DOCK9A001-C-108HumanColorectumFAP8.38e-07-2.74e-01-0.0272
23348DOCK9A002-C-205HumanColorectumFAP2.63e-12-3.84e-01-0.1236
23348DOCK9A015-C-006HumanColorectumFAP4.67e-07-3.81e-01-0.0994
23348DOCK9A015-C-106HumanColorectumFAP4.36e-07-2.08e-01-0.0511
23348DOCK9A002-C-114HumanColorectumFAP5.80e-11-3.72e-01-0.1561
23348DOCK9A015-C-104HumanColorectumFAP1.47e-21-4.62e-01-0.1899
23348DOCK9A001-C-014HumanColorectumFAP1.24e-04-1.39e-010.0135
23348DOCK9A002-C-016HumanColorectumFAP7.29e-15-2.86e-010.0521
23348DOCK9A015-C-002HumanColorectumFAP2.62e-04-2.19e-01-0.0763
23348DOCK9A001-C-203HumanColorectumFAP2.48e-05-1.37e-01-0.0481
23348DOCK9A002-C-116HumanColorectumFAP7.64e-21-3.74e-01-0.0452
Page: 1 2 3 4 5 6 7 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00430877CervixCCregulation of GTPase activity79/2311348/187234.21e-082.60e-0679
GO:00435476CervixCCpositive regulation of GTPase activity53/2311255/187238.72e-051.16e-0353
GO:0043087ColorectumADregulation of GTPase activity110/3918348/187231.64e-065.03e-05110
GO:0043547ColorectumADpositive regulation of GTPase activity75/3918255/187237.95e-047.91e-0375
GO:00430872ColorectumMSSregulation of GTPase activity101/3467348/187231.00e-063.46e-05101
GO:00435471ColorectumMSSpositive regulation of GTPase activity68/3467255/187237.97e-048.38e-0368
GO:00430873ColorectumFAPregulation of GTPase activity85/2622348/187231.20e-077.68e-0685
GO:00435472ColorectumFAPpositive regulation of GTPase activity61/2622255/187231.39e-053.73e-0461
GO:00430874ColorectumCRCregulation of GTPase activity69/2078348/187231.11e-066.69e-0569
GO:00435473ColorectumCRCpositive regulation of GTPase activity49/2078255/187238.67e-051.77e-0349
GO:004308715EsophagusESCCregulation of GTPase activity183/8552348/187235.34e-032.00e-02183
GO:00430876LungIACregulation of GTPase activity67/2061348/187233.43e-061.44e-0467
GO:00435475LungIACpositive regulation of GTPase activity48/2061255/187231.40e-042.60e-0348
GO:004308711LungAISregulation of GTPase activity65/1849348/187233.35e-072.83e-0565
GO:004354711LungAISpositive regulation of GTPase activity44/1849255/187231.74e-043.64e-0344
GO:004308721LungMIACregulation of GTPase activity41/967348/187237.39e-071.08e-0441
GO:004354721LungMIACpositive regulation of GTPase activity31/967255/187238.63e-067.38e-0431
GO:004308710Oral cavityOSCCregulation of GTPase activity165/7305348/187237.94e-044.27e-03165
GO:004308722Oral cavityNEOLPregulation of GTPase activity54/2005348/187233.36e-032.00e-0254
GO:00430879ProstateBPHregulation of GTPase activity88/3107348/187232.04e-052.49e-0488
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DOCK9SNVMissense_Mutationrs752448425c.3494A>Cp.Tyr1165Serp.Y1165SQ9BZ29protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A2-A04Q-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
DOCK9SNVMissense_Mutationc.1778N>Tp.Ser593Leup.S593LQ9BZ29protein_codingtolerated(0.33)benign(0)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
DOCK9SNVMissense_Mutationrs758650602c.3701N>Ap.Ser1234Tyrp.S1234YQ9BZ29protein_codingdeleterious(0.01)benign(0.272)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DOCK9SNVMissense_Mutationnovelc.6057C>Ap.Phe2019Leup.F2019LQ9BZ29protein_codingdeleterious(0)probably_damaging(0.994)TCGA-AN-A049-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DOCK9SNVMissense_Mutationc.2406G>Tp.Trp802Cysp.W802CQ9BZ29protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AN-A0FW-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
DOCK9SNVMissense_Mutationc.5637N>Tp.Leu1879Phep.L1879FQ9BZ29protein_codingdeleterious(0.02)possibly_damaging(0.622)TCGA-BH-A0B4-01Breastbreast invasive carcinomaMale>=65III/IVHormone TherapytamoxiphenSD
DOCK9SNVMissense_Mutationnovelc.6052G>Ap.Val2018Ilep.V2018IQ9BZ29protein_codingtolerated(1)benign(0.042)TCGA-BH-A0BR-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DOCK9SNVMissense_Mutationrs752448425c.3494N>Cp.Tyr1165Serp.Y1165SQ9BZ29protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A1EX-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
DOCK9SNVMissense_Mutationrs761997091c.451G>Ap.Val151Ilep.V151IQ9BZ29protein_codingtolerated(0.31)benign(0.012)TCGA-C8-A131-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilCR
DOCK9SNVMissense_Mutationc.3826G>Tp.Asp1276Tyrp.D1276YQ9BZ29protein_codingdeleterious(0)benign(0.041)TCGA-D8-A1J8-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapynolvadexSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1